Enzymatic Dissolution of Biocomposite Solids Consisting of Phosphopeptides to Form Supramolecular Hydrogels

Handle URI:
http://hdl.handle.net/10754/579911
Title:
Enzymatic Dissolution of Biocomposite Solids Consisting of Phosphopeptides to Form Supramolecular Hydrogels
Authors:
Shi, Junfeng; Yuan, Dan; Haburcak, Richard; Zhang, Qiang; Zhao, Chao ( 0000-0002-9582-1068 ) ; Zhang, Xixiang ( 0000-0002-3478-6414 ) ; Xu, Bing
Abstract:
Enzyme-catalyzed dephosphorylation is essential for biomineralization and bone metabolism. Here we report the exploration of using enzymatic reaction to transform biocomposites of phosphopeptides and calcium (or strontium) ions to supramolecular hydrogels as a mimic of enzymatic dissolution of biominerals. 31P NMR shows that strong affinity between the phosphopeptides and alkaline metal ions (e.g., Ca2+ or Sr2+) induces the formation of biocomposites as precipitates. Electron microscopy reveals that the enzymatic reaction regulates the morphological transition from particles to nanofibers. Rheology confirms the formation of a rigid hydrogel. As the first example of enzyme-instructed dissolution of a solid to form supramolecular nanofibers/hydrogels, this work provides an approach to generate soft materials with desired properties, expands the application of supramolecular hydrogelators, and offers insights to control the demineralization of calcified soft tissues.
KAUST Department:
Nano-fabrication, Imaging & Characterization Core Lab; Physical Sciences and Engineering (PSE) Division
Citation:
Enzymatic Dissolution of Biocomposite Solids Consisting of Phosphopeptides to Form Supramolecular Hydrogels 2015:n/a Chemistry - A European Journal
Publisher:
Wiley-Blackwell
Journal:
Chemistry - A European Journal
Issue Date:
14-Oct-2015
DOI:
10.1002/chem.201504087
Type:
Article
ISSN:
09476539
Additional Links:
http://doi.wiley.com/10.1002/chem.201504087
Appears in Collections:
Articles; Physical Sciences and Engineering (PSE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorShi, Junfengen
dc.contributor.authorYuan, Danen
dc.contributor.authorHaburcak, Richarden
dc.contributor.authorZhang, Qiangen
dc.contributor.authorZhao, Chaoen
dc.contributor.authorZhang, Xixiangen
dc.contributor.authorXu, Bingen
dc.date.accessioned2015-10-20T09:53:12Zen
dc.date.available2015-10-20T09:53:12Zen
dc.date.issued2015-10-14en
dc.identifier.citationEnzymatic Dissolution of Biocomposite Solids Consisting of Phosphopeptides to Form Supramolecular Hydrogels 2015:n/a Chemistry - A European Journalen
dc.identifier.issn09476539en
dc.identifier.doi10.1002/chem.201504087en
dc.identifier.urihttp://hdl.handle.net/10754/579911en
dc.description.abstractEnzyme-catalyzed dephosphorylation is essential for biomineralization and bone metabolism. Here we report the exploration of using enzymatic reaction to transform biocomposites of phosphopeptides and calcium (or strontium) ions to supramolecular hydrogels as a mimic of enzymatic dissolution of biominerals. 31P NMR shows that strong affinity between the phosphopeptides and alkaline metal ions (e.g., Ca2+ or Sr2+) induces the formation of biocomposites as precipitates. Electron microscopy reveals that the enzymatic reaction regulates the morphological transition from particles to nanofibers. Rheology confirms the formation of a rigid hydrogel. As the first example of enzyme-instructed dissolution of a solid to form supramolecular nanofibers/hydrogels, this work provides an approach to generate soft materials with desired properties, expands the application of supramolecular hydrogelators, and offers insights to control the demineralization of calcified soft tissues.en
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.relation.urlhttp://doi.wiley.com/10.1002/chem.201504087en
dc.rightsThis is the peer reviewed version of the following article: Shi, Junfeng, Dan Yuan, Richard Haburcak, Qiang Zhang, Chao Zhao, Xixiang Zhang, and Bing Xu. "Enzymatic Dissolution of Biocomposite Solids Consisting of Phosphopeptides to Form Supramolecular Hydrogels." Chemistry-A European Journal (2015)., which has been published in final form at http://doi.wiley.com/10.1002/chem.201504087. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.en
dc.subjectphosphopeptideen
dc.subjectsolid-gel transitionen
dc.subjectenzymeen
dc.subjectself-assemblyen
dc.subjectbone mineralizationen
dc.titleEnzymatic Dissolution of Biocomposite Solids Consisting of Phosphopeptides to Form Supramolecular Hydrogelsen
dc.typeArticleen
dc.contributor.departmentNano-fabrication, Imaging & Characterization Core Laben
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.identifier.journalChemistry - A European Journalen
dc.eprint.versionPost-printen
dc.contributor.institutionDepartment of Chemistry; Brandeis University; Waltham UNITED STATESen
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorZhang, Qiangen
kaust.authorZhao, Chaoen
kaust.authorZhang, Xixiangen
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