Capacitive immunosensor for C-reactive protein quantification

Handle URI:
http://hdl.handle.net/10754/579413
Title:
Capacitive immunosensor for C-reactive protein quantification
Authors:
Sapsanis, Christos ( 0000-0003-3875-5110 ) ; Sivashankar, Shilpa; Omran, Hesham ( 0000-0002-0117-7364 ) ; Buttner, Ulrich; Salama, Khaled N. ( 0000-0001-7742-1282 )
Abstract:
We report an agglutination-based immunosensor for the quantification of C-reactive protein (CRP). The developed immunoassay sensor requires approximately 15 minutes of assay time per sample and provides a sensitivity of 0.5 mg/L. We have measured the capacitance of interdigitated electrodes (IDEs) and quantified the concentration of added analyte. The proposed method is a label free detection method and hence provides rapid measurement preferable in diagnostics. We have so far been able to quantify the concentration to as low as 0.5 mg/L and as high as 10 mg/L. By quantifying CRP in serum, we can assess whether patients are prone to cardiac diseases and monitor the risk associated with such diseases. The sensor is a simple low cost structure and it can be a promising device for rapid and sensitive detection of disease markers at the point-of-care stage.
KAUST Department:
Sensors Lab; Electrical Engineering Program
Publisher:
Institute of Electrical and Electronics Engineers (IEEE)
Journal:
2015 IEEE 58th International Midwest Symposium on Circuits and Systems (MWSCAS)
Conference/Event name:
2015 IEEE 58th International Midwest Symposium on Circuits and Systems (MWSCAS)
Issue Date:
2-Aug-2015
DOI:
10.1109/MWSCAS.2015.7282094
Type:
Conference Paper
Additional Links:
http://ieeexplore.ieee.org/lpdocs/epic03/wrapper.htm?arnumber=7282094
Appears in Collections:
Conference Papers; Electrical Engineering Program; Sensors Lab

Full metadata record

DC FieldValue Language
dc.contributor.authorSapsanis, Christosen
dc.contributor.authorSivashankar, Shilpaen
dc.contributor.authorOmran, Heshamen
dc.contributor.authorButtner, Ulrichen
dc.contributor.authorSalama, Khaled N.en
dc.date.accessioned2015-10-07T09:04:30Zen
dc.date.available2015-10-07T09:04:30Zen
dc.date.issued2015-08-02en
dc.identifier.doi10.1109/MWSCAS.2015.7282094en
dc.identifier.urihttp://hdl.handle.net/10754/579413en
dc.description.abstractWe report an agglutination-based immunosensor for the quantification of C-reactive protein (CRP). The developed immunoassay sensor requires approximately 15 minutes of assay time per sample and provides a sensitivity of 0.5 mg/L. We have measured the capacitance of interdigitated electrodes (IDEs) and quantified the concentration of added analyte. The proposed method is a label free detection method and hence provides rapid measurement preferable in diagnostics. We have so far been able to quantify the concentration to as low as 0.5 mg/L and as high as 10 mg/L. By quantifying CRP in serum, we can assess whether patients are prone to cardiac diseases and monitor the risk associated with such diseases. The sensor is a simple low cost structure and it can be a promising device for rapid and sensitive detection of disease markers at the point-of-care stage.en
dc.publisherInstitute of Electrical and Electronics Engineers (IEEE)en
dc.relation.urlhttp://ieeexplore.ieee.org/lpdocs/epic03/wrapper.htm?arnumber=7282094en
dc.titleCapacitive immunosensor for C-reactive protein quantificationen
dc.typeConference Paperen
dc.contributor.departmentSensors Laben
dc.contributor.departmentElectrical Engineering Programen
dc.identifier.journal2015 IEEE 58th International Midwest Symposium on Circuits and Systems (MWSCAS)en
dc.conference.date2-5 Aug. 2015en
dc.conference.name2015 IEEE 58th International Midwest Symposium on Circuits and Systems (MWSCAS)en
dc.conference.locationFort Collins, CO, USAen
dc.eprint.versionPublisher's Version/PDFen
kaust.authorSapsanis, Christosen
kaust.authorSivashankar, Shilpaen
kaust.authorOmran, Heshamen
kaust.authorButtner, Ulrichen
kaust.authorSalama, Khaled N.en
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