Photoresponsive Bridged Silsesquioxane Nanoparticles with Tunable Morphology for Light-Triggered Plasmid DNA Delivery

Handle URI:
http://hdl.handle.net/10754/578841
Title:
Photoresponsive Bridged Silsesquioxane Nanoparticles with Tunable Morphology for Light-Triggered Plasmid DNA Delivery
Authors:
Fatieiev, Yevhen; Croissant, Jonas G.; Alsaiari, Shahad K.; Moosa, Basem ( 0000-0002-2350-4100 ) ; Anjum, Dalaver H.; Khashab, Niveen M. ( 0000-0003-2728-0666 )
Abstract:
Bridged silsesquioxane nanocomposites with tunable morphologies incorporating o-nitrophenylene-ammonium bridges are described. The systematic screening of the sol-gel parameters allowed the material to reach the nanoscale –unlike most reported bridged silsesquioxane materials– with controlled dense and hollow structures of 100 to 200 nm. The hybrid composition of silsesquioxanes with 50% of organic content homogenously distributed in the nanomaterials endowed them with photoresponsive properties. Light irradiation was performed to reverse the surface charge of nanoparticles from +46 to -39 mV via the photoreaction of the organic fragments within the particles, as confirmed by spectroscopic monitorings. Furthermore, such NPs were ap-plied for the first time for the on-demand delivery of plasmid DNA in HeLa cancer cells via light actuation.
KAUST Department:
Smart Hybrid Materials (SHMs) lab; Imaging and Characterization Core Lab; Advanced Membranes and Porous Materials Research Center
Citation:
Photoresponsive Bridged Silsesquioxane Nanoparticles with Tunable Morphology for Light-Triggered Plasmid DNA Delivery 2015:150925103151004 ACS Applied Materials & Interfaces
Publisher:
American Chemical Society (ACS)
Journal:
ACS Applied Materials & Interfaces
Issue Date:
25-Sep-2015
DOI:
10.1021/acsami.5b07365
Type:
Article
ISSN:
1944-8244; 1944-8252
Additional Links:
http://pubs.acs.org/doi/10.1021/acsami.5b07365
Appears in Collections:
Articles; Advanced Membranes and Porous Materials Research Center; Advanced Nanofabrication, Imaging and Characterization Core Lab; Controlled Release and Delivery Laboratory

Full metadata record

DC FieldValue Language
dc.contributor.authorFatieiev, Yevhenen
dc.contributor.authorCroissant, Jonas G.en
dc.contributor.authorAlsaiari, Shahad K.en
dc.contributor.authorMoosa, Basemen
dc.contributor.authorAnjum, Dalaver H.en
dc.contributor.authorKhashab, Niveen M.en
dc.date.accessioned2015-09-29T05:16:10Zen
dc.date.available2015-09-29T05:16:10Zen
dc.date.issued2015-09-25en
dc.identifier.citationPhotoresponsive Bridged Silsesquioxane Nanoparticles with Tunable Morphology for Light-Triggered Plasmid DNA Delivery 2015:150925103151004 ACS Applied Materials & Interfacesen
dc.identifier.issn1944-8244en
dc.identifier.issn1944-8252en
dc.identifier.doi10.1021/acsami.5b07365en
dc.identifier.urihttp://hdl.handle.net/10754/578841en
dc.description.abstractBridged silsesquioxane nanocomposites with tunable morphologies incorporating o-nitrophenylene-ammonium bridges are described. The systematic screening of the sol-gel parameters allowed the material to reach the nanoscale –unlike most reported bridged silsesquioxane materials– with controlled dense and hollow structures of 100 to 200 nm. The hybrid composition of silsesquioxanes with 50% of organic content homogenously distributed in the nanomaterials endowed them with photoresponsive properties. Light irradiation was performed to reverse the surface charge of nanoparticles from +46 to -39 mV via the photoreaction of the organic fragments within the particles, as confirmed by spectroscopic monitorings. Furthermore, such NPs were ap-plied for the first time for the on-demand delivery of plasmid DNA in HeLa cancer cells via light actuation.en
dc.language.isoenen
dc.publisherAmerican Chemical Society (ACS)en
dc.relation.urlhttp://pubs.acs.org/doi/10.1021/acsami.5b07365en
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Materials & Interfaces, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/10.1021/acsami.5b07365.en
dc.titlePhotoresponsive Bridged Silsesquioxane Nanoparticles with Tunable Morphology for Light-Triggered Plasmid DNA Deliveryen
dc.typeArticleen
dc.contributor.departmentSmart Hybrid Materials (SHMs) laben
dc.contributor.departmentImaging and Characterization Core Laben
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Centeren
dc.identifier.journalACS Applied Materials & Interfacesen
dc.eprint.versionPost-printen
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)en
kaust.authorKhashab, Niveen M.en
kaust.authorFatieiev, Yevhenen
kaust.authorCroissant, Jonas G.en
kaust.authorAlsaiari, Shahad K.en
kaust.authorMoosa, Basemen
kaust.authorAnjum, Dalaver H.en
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