Electromagnetically powered electrolytic pump and thermo-responsive valve for drug delivery

Handle URI:
http://hdl.handle.net/10754/577107
Title:
Electromagnetically powered electrolytic pump and thermo-responsive valve for drug delivery
Authors:
Yi, Ying; Zaher, Amir; Yassine, Omar ( 0000-0002-0117-8017 ) ; Buttner, Ulrich; Kosel, Jürgen ( 0000-0002-8998-8275 ) ; Foulds, Ian G.
Abstract:
A novel drug delivery device is presented, implementing an electrolytic pump and a thermo-responsive valve. The device is remotely operated by an AC electromagnetic field (40.5∼58.5 mT, 450 kHz) that provides the power for the pump and the valve. It is suitable for long-term therapy applications, which use a solid drug in reservoir (SDR) approach and avoids unwanted drug diffusion. When the electromagnetic field is on, the electrolytic pump drives the drug towards the valve. The valve is made of a magnetic composite consisting of a smart hydrogel: Poly (N-Isopropylacrylamide) (PNIPAm) and iron powder. The heat generated in the iron powder via magnetic losses causes the PNIPAm to shrink, allowing the drug to flow past it. When the electromagnetic field is off, the PNIPAm swells, sealing the outlet. In the meantime, the bubbles generated by electrolysis recombine into water, causing a pressure reduction in the pumping chamber. This draws fresh fluid from outside the pump into the drug reservoir before the valve is fully sealed. The recombination can be accelerated by a platinum (Pt) coated catalytic reformer, allowing more fluid to flow back to the drug reservoir and dissolve the drug. By repeatedly turning on and off the magnetic field, the drug solution can be delivered cyclically. © 2015 IEEE.
KAUST Department:
Electrical Engineering Program; Physical Sciences and Engineering (PSE) Division; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division; Sensing, Magnetism and Microsystems Lab
Publisher:
Institute of Electrical & Electronics Engineers (IEEE)
Journal:
10th IEEE International Conference on Nano/Micro Engineered and Molecular Systems
Conference/Event name:
10th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2015
Issue Date:
Apr-2015
DOI:
10.1109/NEMS.2015.7147344
Type:
Conference Paper
Appears in Collections:
Conference Papers; Physical Sciences and Engineering (PSE) Division; Electrical Engineering Program; Sensing, Magnetism and Microsystems Lab; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorYi, Yingen
dc.contributor.authorZaher, Amiren
dc.contributor.authorYassine, Omaren
dc.contributor.authorButtner, Ulrichen
dc.contributor.authorKosel, Jürgenen
dc.contributor.authorFoulds, Ian G.en
dc.date.accessioned2015-09-10T14:18:28Zen
dc.date.available2015-09-10T14:18:28Zen
dc.date.issued2015-04en
dc.identifier.doi10.1109/NEMS.2015.7147344en
dc.identifier.urihttp://hdl.handle.net/10754/577107en
dc.description.abstractA novel drug delivery device is presented, implementing an electrolytic pump and a thermo-responsive valve. The device is remotely operated by an AC electromagnetic field (40.5∼58.5 mT, 450 kHz) that provides the power for the pump and the valve. It is suitable for long-term therapy applications, which use a solid drug in reservoir (SDR) approach and avoids unwanted drug diffusion. When the electromagnetic field is on, the electrolytic pump drives the drug towards the valve. The valve is made of a magnetic composite consisting of a smart hydrogel: Poly (N-Isopropylacrylamide) (PNIPAm) and iron powder. The heat generated in the iron powder via magnetic losses causes the PNIPAm to shrink, allowing the drug to flow past it. When the electromagnetic field is off, the PNIPAm swells, sealing the outlet. In the meantime, the bubbles generated by electrolysis recombine into water, causing a pressure reduction in the pumping chamber. This draws fresh fluid from outside the pump into the drug reservoir before the valve is fully sealed. The recombination can be accelerated by a platinum (Pt) coated catalytic reformer, allowing more fluid to flow back to the drug reservoir and dissolve the drug. By repeatedly turning on and off the magnetic field, the drug solution can be delivered cyclically. © 2015 IEEE.en
dc.publisherInstitute of Electrical & Electronics Engineers (IEEE)en
dc.subjectdrug deliveryen
dc.subjectPNIPAm valveen
dc.subjectSDRen
dc.titleElectromagnetically powered electrolytic pump and thermo-responsive valve for drug deliveryen
dc.typeConference Paperen
dc.contributor.departmentElectrical Engineering Programen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Divisionen
dc.contributor.departmentSensing, Magnetism and Microsystems Laben
dc.identifier.journal10th IEEE International Conference on Nano/Micro Engineered and Molecular Systemsen
dc.conference.date7 April 2015 through 11 April 2015en
dc.conference.name10th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2015en
dc.contributor.institutionSchool of Engineeringen
kaust.authorYi, Yingen
kaust.authorYassine, Omaren
kaust.authorButtner, Ulrichen
kaust.authorKosel, Jürgenen
kaust.authorFoulds, Ian G.en
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