Clinical developments of chemotherapeutic nanomedicines: Polymers and liposomes for delivery of camptothecins and platinum (II) drugs

Handle URI:
http://hdl.handle.net/10754/577044
Title:
Clinical developments of chemotherapeutic nanomedicines: Polymers and liposomes for delivery of camptothecins and platinum (II) drugs
Authors:
Kieler-Ferguson, Heidi M.; Frechet, Jean ( 0000-0001-6419-0163 ) ; Szoka, Francis C.
Abstract:
For the past 40 years, liposomal and polymeric delivery vehicles have been studied as systems capable of modulating the cytotoxicity of small molecule chemotherapeutics, increasing tumor bearing animal survival times, and improving drug targeting. Although a number of macromolecular-drug conjugates have progressed to clinical trials, tuning drug release to maintain efficacy in conjunction with controlling drug toxicity has prevented the clinical adoption of many vehicles. In this article, we review the motivations for and approaches to polymer and liposomal delivery with regard to camptothecin and cisplatin delivery. WIREs Nanomed Nanobiotechnol 2013, 5:130-138. doi: 10.1002/wnan.1209 For further resources related to this article, please visit the WIREs website. Conflict of interest: Drs Kieler-Ferguson and Fréchet declare no conflicts of interest. Dr Szoka is the founder of a liposome drug delivery company that is not working on any of the compounds mentioned in this article. © 2013 Wiley Periodicals, Inc.
KAUST Department:
Physical Sciences and Engineering (PSE) Division; Chemical Science Program
Publisher:
Wiley-Blackwell
Journal:
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
Issue Date:
17-Jan-2013
DOI:
10.1002/wnan.1209
PubMed ID:
23335566
Type:
Article
ISSN:
19395116
Sponsors:
Portions of this work were supported by NIH R01 grants GM061851 and EB002047.
Appears in Collections:
Articles; Physical Sciences and Engineering (PSE) Division; Chemical Science Program

Full metadata record

DC FieldValue Language
dc.contributor.authorKieler-Ferguson, Heidi M.en
dc.contributor.authorFrechet, Jeanen
dc.contributor.authorSzoka, Francis C.en
dc.date.accessioned2015-09-10T09:27:26Zen
dc.date.available2015-09-10T09:27:26Zen
dc.date.issued2013-01-17en
dc.identifier.issn19395116en
dc.identifier.pmid23335566en
dc.identifier.doi10.1002/wnan.1209en
dc.identifier.urihttp://hdl.handle.net/10754/577044en
dc.description.abstractFor the past 40 years, liposomal and polymeric delivery vehicles have been studied as systems capable of modulating the cytotoxicity of small molecule chemotherapeutics, increasing tumor bearing animal survival times, and improving drug targeting. Although a number of macromolecular-drug conjugates have progressed to clinical trials, tuning drug release to maintain efficacy in conjunction with controlling drug toxicity has prevented the clinical adoption of many vehicles. In this article, we review the motivations for and approaches to polymer and liposomal delivery with regard to camptothecin and cisplatin delivery. WIREs Nanomed Nanobiotechnol 2013, 5:130-138. doi: 10.1002/wnan.1209 For further resources related to this article, please visit the WIREs website. Conflict of interest: Drs Kieler-Ferguson and Fréchet declare no conflicts of interest. Dr Szoka is the founder of a liposome drug delivery company that is not working on any of the compounds mentioned in this article. © 2013 Wiley Periodicals, Inc.en
dc.description.sponsorshipPortions of this work were supported by NIH R01 grants GM061851 and EB002047.en
dc.publisherWiley-Blackwellen
dc.titleClinical developments of chemotherapeutic nanomedicines: Polymers and liposomes for delivery of camptothecins and platinum (II) drugsen
dc.typeArticleen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.contributor.departmentChemical Science Programen
dc.identifier.journalWiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnologyen
dc.contributor.institutionCollege of Chemistry, University of California, Berkeley, CA, United Statesen
dc.contributor.institutionDepartment of Bioengineering, Therapeutic Sciences and Pharmaceutical Chemistry, University of California, San Francisco, CA, United Statesen
kaust.authorFrechet, Jeanen

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