Mechanised nanoparticles for drug delivery

Handle URI:
http://hdl.handle.net/10754/575905
Title:
Mechanised nanoparticles for drug delivery
Authors:
Cotí, Karla K.; Belowich, Matthew E.; Liong, Monty; Ambrogio, Michael W.; Lau, Yuen A.; Khatib, Hussam A.; Zink, Jeffrey I.; Khashab, Niveen M. ( 0000-0003-2728-0666 ) ; Stoddart, J. Fraser
Abstract:
Time and time again humanity is faced with a unifying global crisis that crosses the many great divides in different societies and serves to bring once segregated communities back together as a collective whole. This global community instinctively turns to science to develop the means of addressing its most pressing problems. More often than not. these forces dictate the direction that scientific research takes. This influence is no more apparent than in the field of supramolecular chemistry where, for decades now, its responsibility to tackle such issues has been put oil the back burner as a consequence of a lack of platforms with which to deliver this contemporary brand of chemistry to meaningful applications. However, the tide is slowly turning as new materials emerge from the field of nanotechnology that are poised to host the many attractive attributes that are inherent in the chemistry of these supermolecules and also in the mechanostereochemistry of mechanically interlocked molecules (MIMS), which can be reused as a sequel to supramolecular chemistry. Mesoporous silica nanoparticles (SNPs) have proven to be supremely effective solid Supports as their Surfaces are easily functionalised with either supermolecules Or MIMS. In turn, the blending of supramolecular chemistry and mechanostereochemistry with mesoporous SNPs had led to a new class of materials - namely, mechanised SNPs that are effectively biological nanoscale 'bombs' that have the potential to infiltrate cells and then, upon the pulling of a chemical trigger, explode! The development of these materials has been driven by the need to devise new therapies for the treatment of cancer. Recent progess in research promises not only to control the acuteness of this widespread and insidious disease, but also to make the harsh treatment less debilitating to patients. This global scourge is the unifying force that has brought together supramolecular chemistry, mechanostereochemistry and nanotechnology, uniting these three communities for the common good. At the nanoscale level. the mechanism for the release of cargos from the confines of the nanopores in the SNPS is accomplished by way of mechanical modifications made on the surface of these functionalised supports. These mechanical motions rely on both supramolecular, i.e., host-guest complexes, and mechanostereochemical phenomena (e.g.. bistable rotaxanes), which are often Stimulated by changes in pH light and redox potentials. in addition to enzymatic catalysis. The future of this field lies in the development of bombs' wherein the loaded mechanised SNIPS are endocytosed selectively by cancer cells, whereupon an intracellular trigger causes release of of cytotoxin, effectively leading to apoptosis. This review serves to highlight (1) the evolution of surface-functionalisation of SNPs with supermolecules and also with MIMs, (2) the mechanisms through which controlled-release of cargo from mechanised SNPs Occurs, and (3) results from the ill vitro application of these mechanised SNPs.
KAUST Department:
Physical Sciences and Engineering (PSE) Division; Chemical Science Program; Advanced Membranes and Porous Materials Research Center; Chemical Science Program; Smart Hybrid Materials (SHMs) lab
Publisher:
Royal Society of Chemistry (RSC)
Journal:
Nanoscale
Issue Date:
4-Sep-2009
DOI:
10.1039/b9nr00162j
Type:
Article
ISSN:
2040-3364; 2040-3372
Appears in Collections:
Articles; Advanced Membranes and Porous Materials Research Center; Advanced Membranes and Porous Materials Research Center; Physical Sciences and Engineering (PSE) Division; Controlled Release and Delivery Laboratory; Controlled Release and Delivery Laboratory; Chemical Science Program; Chemical Science Program

Full metadata record

DC FieldValue Language
dc.contributor.authorCotí, Karla K.en
dc.contributor.authorBelowich, Matthew E.en
dc.contributor.authorLiong, Montyen
dc.contributor.authorAmbrogio, Michael W.en
dc.contributor.authorLau, Yuen A.en
dc.contributor.authorKhatib, Hussam A.en
dc.contributor.authorZink, Jeffrey I.en
dc.contributor.authorKhashab, Niveen M.en
dc.contributor.authorStoddart, J. Fraseren
dc.date.accessioned2015-08-25T06:18:57Zen
dc.date.available2015-08-25T06:18:57Zen
dc.date.issued2009-09-04en
dc.identifier.issn2040-3364en
dc.identifier.issn2040-3372en
dc.identifier.doi10.1039/b9nr00162jen
dc.identifier.urihttp://hdl.handle.net/10754/575905en
dc.description.abstractTime and time again humanity is faced with a unifying global crisis that crosses the many great divides in different societies and serves to bring once segregated communities back together as a collective whole. This global community instinctively turns to science to develop the means of addressing its most pressing problems. More often than not. these forces dictate the direction that scientific research takes. This influence is no more apparent than in the field of supramolecular chemistry where, for decades now, its responsibility to tackle such issues has been put oil the back burner as a consequence of a lack of platforms with which to deliver this contemporary brand of chemistry to meaningful applications. However, the tide is slowly turning as new materials emerge from the field of nanotechnology that are poised to host the many attractive attributes that are inherent in the chemistry of these supermolecules and also in the mechanostereochemistry of mechanically interlocked molecules (MIMS), which can be reused as a sequel to supramolecular chemistry. Mesoporous silica nanoparticles (SNPs) have proven to be supremely effective solid Supports as their Surfaces are easily functionalised with either supermolecules Or MIMS. In turn, the blending of supramolecular chemistry and mechanostereochemistry with mesoporous SNPs had led to a new class of materials - namely, mechanised SNPs that are effectively biological nanoscale 'bombs' that have the potential to infiltrate cells and then, upon the pulling of a chemical trigger, explode! The development of these materials has been driven by the need to devise new therapies for the treatment of cancer. Recent progess in research promises not only to control the acuteness of this widespread and insidious disease, but also to make the harsh treatment less debilitating to patients. This global scourge is the unifying force that has brought together supramolecular chemistry, mechanostereochemistry and nanotechnology, uniting these three communities for the common good. At the nanoscale level. the mechanism for the release of cargos from the confines of the nanopores in the SNPS is accomplished by way of mechanical modifications made on the surface of these functionalised supports. These mechanical motions rely on both supramolecular, i.e., host-guest complexes, and mechanostereochemical phenomena (e.g.. bistable rotaxanes), which are often Stimulated by changes in pH light and redox potentials. in addition to enzymatic catalysis. The future of this field lies in the development of bombs' wherein the loaded mechanised SNIPS are endocytosed selectively by cancer cells, whereupon an intracellular trigger causes release of of cytotoxin, effectively leading to apoptosis. This review serves to highlight (1) the evolution of surface-functionalisation of SNPs with supermolecules and also with MIMs, (2) the mechanisms through which controlled-release of cargo from mechanised SNPs Occurs, and (3) results from the ill vitro application of these mechanised SNPs.en
dc.publisherRoyal Society of Chemistry (RSC)en
dc.titleMechanised nanoparticles for drug deliveryen
dc.typeArticleen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.contributor.departmentChemical Science Programen
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Centeren
dc.contributor.departmentChemical Science Programen
dc.contributor.departmentSmart Hybrid Materials (SHMs) laben
dc.identifier.journalNanoscaleen
dc.contributor.institutionUniv Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USAen
dc.contributor.institutionNorthwestern Univ, Dept Chem, Evanston, IL 60208 USAen
kaust.authorKhashab, Niveen M.en
kaust.authorKhatib, Hussam A.en
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