Catalytic properties and biomedical applications of cerium oxide nanoparticles

Handle URI:
http://hdl.handle.net/10754/575893
Title:
Catalytic properties and biomedical applications of cerium oxide nanoparticles
Authors:
Walkey, Carl D.; Das, Soumen C.; Seal, Sudipta; Erlichman, Joseph S.; Heckman, Karin L.; Ghibelli, Lina; Traversa, Enrico ( 0000-0001-6336-941X ) ; McGinnis, James F.; Self, William Thomas
Abstract:
Cerium oxide nanoparticles (nanoceria) have shown promise as catalytic antioxidants in the test tube, cell culture models and animal models of disease. However given the reactivity that is well established at the surface of these nanoparticles, the biological utilization of nanoceria as a therapeutic still poses many challenges. Moreover the form that these particles take in a biological environment, such as the changes that can occur due to a protein corona, are not well established. This review aims to summarize the existing literature on biological use of nanoceria, and to raise questions about what further study is needed to apply this interesting catalytic material to biomedical applications. These questions include: 1) How does preparation, exposure dose, route and experimental model influence the reported effects of nanoceria in animal studies? 2) What are the considerations to develop nanoceria as a therapeutic agent in regards to these parameters? 3) What biological targets of reactive oxygen species (ROS) and reactive nitrogen species (RNS) are relevant to this targeting, and how do these properties also influence the safety of these nanomaterials?
KAUST Department:
Physical Sciences and Engineering (PSE) Division; Materials Science and Engineering Program; Solar and Photovoltaic Engineering Research Center (SPERC); Materials for Energy Conversion and Storage (MECS) Lab
Publisher:
Royal Society of Chemistry (RSC)
Journal:
Environ. Sci.: Nano
Issue Date:
10-Nov-2014
DOI:
10.1039/c4en00138a
Type:
Article
ISSN:
20518153
Sponsors:
JFM work was supported by NIH NEI grant COBRE-P20 RR017703, P30-EY 12190, R21EY018306, R01EY18724, R01EY022111; National Science Foundation: CBET-0708172; Foundation Fighting Blindness.This article is a product of a workshop on nanoceria held November 2, 2013 at the Fess Parker Doubletree Resort, Santa Barbara, CA, made possible by financial support from the Sustainable Nanotechnology Organization, The Tracy Farmer Institute for Sustainability and the Environment, the Department of Pharmaceutical Sciences, Associate Dean of Research of the College of Pharmacy and Office of the Vice President for Research, University of Kentucky.
Appears in Collections:
Articles; Physical Sciences and Engineering (PSE) Division; Physical Sciences and Engineering (PSE) Division; Materials Science and Engineering Program; Materials Science and Engineering Program; Solar and Photovoltaic Engineering Research Center (SPERC); Solar and Photovoltaic Engineering Research Center (SPERC)

Full metadata record

DC FieldValue Language
dc.contributor.authorWalkey, Carl D.en
dc.contributor.authorDas, Soumen C.en
dc.contributor.authorSeal, Sudiptaen
dc.contributor.authorErlichman, Joseph S.en
dc.contributor.authorHeckman, Karin L.en
dc.contributor.authorGhibelli, Linaen
dc.contributor.authorTraversa, Enricoen
dc.contributor.authorMcGinnis, James F.en
dc.contributor.authorSelf, William Thomasen
dc.date.accessioned2015-08-25T06:18:21Zen
dc.date.available2015-08-25T06:18:21Zen
dc.date.issued2014-11-10en
dc.identifier.issn20518153en
dc.identifier.doi10.1039/c4en00138aen
dc.identifier.urihttp://hdl.handle.net/10754/575893en
dc.description.abstractCerium oxide nanoparticles (nanoceria) have shown promise as catalytic antioxidants in the test tube, cell culture models and animal models of disease. However given the reactivity that is well established at the surface of these nanoparticles, the biological utilization of nanoceria as a therapeutic still poses many challenges. Moreover the form that these particles take in a biological environment, such as the changes that can occur due to a protein corona, are not well established. This review aims to summarize the existing literature on biological use of nanoceria, and to raise questions about what further study is needed to apply this interesting catalytic material to biomedical applications. These questions include: 1) How does preparation, exposure dose, route and experimental model influence the reported effects of nanoceria in animal studies? 2) What are the considerations to develop nanoceria as a therapeutic agent in regards to these parameters? 3) What biological targets of reactive oxygen species (ROS) and reactive nitrogen species (RNS) are relevant to this targeting, and how do these properties also influence the safety of these nanomaterials?en
dc.description.sponsorshipJFM work was supported by NIH NEI grant COBRE-P20 RR017703, P30-EY 12190, R21EY018306, R01EY18724, R01EY022111; National Science Foundation: CBET-0708172; Foundation Fighting Blindness.This article is a product of a workshop on nanoceria held November 2, 2013 at the Fess Parker Doubletree Resort, Santa Barbara, CA, made possible by financial support from the Sustainable Nanotechnology Organization, The Tracy Farmer Institute for Sustainability and the Environment, the Department of Pharmaceutical Sciences, Associate Dean of Research of the College of Pharmacy and Office of the Vice President for Research, University of Kentucky.en
dc.publisherRoyal Society of Chemistry (RSC)en
dc.titleCatalytic properties and biomedical applications of cerium oxide nanoparticlesen
dc.typeArticleen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.contributor.departmentMaterials Science and Engineering Programen
dc.contributor.departmentSolar and Photovoltaic Engineering Research Center (SPERC)en
dc.contributor.departmentMaterials for Energy Conversion and Storage (MECS) Laben
dc.identifier.journalEnviron. Sci.: Nanoen
dc.contributor.institutionIntegrated Nanotechnology and Biomedical Sciences Laboratory, University of Toronto, Terrence Donnelly Building 160 College St.Toronto, ON, Canadaen
dc.contributor.institutionAdvanced Materials Processing and Analysis Centre, Nanoscience Technology Center, University of Central FloridaOrlando, FL, United Statesen
dc.contributor.institutionDepartment of Biology, St. Lawrence University, Johnson Hall of Science, 23 Romoda DriveCanton, NY, United Statesen
dc.contributor.institutionDepartment of Biology, Università di Roma Tor Vergata, Via Della Ricerca ScientificaRoma, Italyen
dc.contributor.institutionDean A. McGee Eye Institute, Department of Ophthalmology, 608 Stanton L. Young, Blvd.Oklahoma City, OK, United Statesen
dc.contributor.institutionBurnett School of Biomedical Science, College of Medicine, University of Central FloridaOrlando, FL, United Statesen
kaust.authorTraversa, Enricoen
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