Aqueous phase synthesis of upconversion nanocrystals through layer-by-layer epitaxial growth for in vivo X-ray computed tomography

Handle URI:
http://hdl.handle.net/10754/575892
Title:
Aqueous phase synthesis of upconversion nanocrystals through layer-by-layer epitaxial growth for in vivo X-ray computed tomography
Authors:
Li, Feifei; Li, Chunguang; Liu, Jianhua; Liu, Xiaomin; Zhao, Lan; Bai, Tianyu; Yuan, Qinghai; Kong, Xianggui; Han, Yu ( 0000-0003-1462-1118 ) ; Shi, Zhan; Feng, Shouhua
Abstract:
Lanthanide-doped core-shell upconversion nanocrystals (UCNCs) have tremendous potential for applications in many fields, especially in bio-imaging and medical therapy. As core-shell UCNCs are mostly synthesized in organic solvents, tedious organic-aqueous phase transfer processes are usually needed for their use in bio-applications. Herein, we demonstrate the first example of one-step synthesis of highly luminescent core-shell UCNCs in the "aqueous" phase under mild conditions using innocuous reagents. A microwave-assisted approach allowed for layer-by-layer epitaxial growth of a hydrophilic NaGdF4 shell on NaYF4:Yb, Er cores. During this process, surface defects of the nanocrystals could be gradually passivated by the homogeneous shell deposition, resulting in obvious enhancement in the overall upconversion emission efficiency. In addition, the up-down conversion dual-mode luminescent NaYF4:Yb, Er@NaGdF4:Ce, Ln (Eu, Tb, Sm, Dy) nanocrystals were also synthesized to further validate the successful formation of the core-shell structure. More significantly, based on their superior solubility and stability in water solution, high upconversion efficiency and Gd-doped predominant X-ray absorption, the as-prepared NaYF4:Yb, Er@NaGdF4 core-shell UCNCs exhibited high contrast in in vitro cell imaging and in vivo X-ray computed tomography (CT) imaging, demonstrating great potential as multiplexed luminescent biolabels and CT contrast agents.
KAUST Department:
Core Labs; Physical Sciences and Engineering (PSE) Division; Chemical Science Program; Advanced Membranes and Porous Materials Research Center; Chemical Science Program; Nanostructured Functional Materials (NFM) laboratory; Core Labs; Physical Sciences and Engineering (PSE) Division; Chemical Science Program; Advanced Membranes and Porous Materials Research Center; Chemical Science Program; Nanostructured Functional Materials (NFM) laboratory
Publisher:
Royal Society of Chemistry (RSC)
Journal:
Nanoscale
Issue Date:
21-May-2013
DOI:
10.1039/c3nr01530k
Type:
Article
ISSN:
2040-3364; 2040-3372
Sponsors:
This work was supported by the Foundation of the National Natural Science Foundation of China (no. 20971054, 90922034 and 21131002), Specialized Research Fund for the Doctoral Program of Higher Education (no. 20110061110015), National High Technology Research and Develop Program (863 program) of China (no. 2013AA031702) and the Special Program of China Postdoctoral Science Foundation (no. 2012T50288). X. G. Kong would like to thank the NSF of china (no. 11174277 and 61275202). ESI is available online from Wiley InterScience or from the author.
Appears in Collections:
Articles; Advanced Membranes and Porous Materials Research Center; Advanced Nanofabrication, Imaging and Characterization Core Lab; Physical Sciences and Engineering (PSE) Division; Physical Sciences and Engineering (PSE) Division; Chemical Science Program; Chemical Science Program

Full metadata record

DC FieldValue Language
dc.contributor.authorLi, Feifeien
dc.contributor.authorLi, Chunguangen
dc.contributor.authorLiu, Jianhuaen
dc.contributor.authorLiu, Xiaominen
dc.contributor.authorZhao, Lanen
dc.contributor.authorBai, Tianyuen
dc.contributor.authorYuan, Qinghaien
dc.contributor.authorKong, Xiangguien
dc.contributor.authorHan, Yuen
dc.contributor.authorShi, Zhanen
dc.contributor.authorFeng, Shouhuaen
dc.date.accessioned2015-08-25T06:18:16Zen
dc.date.available2015-08-25T06:18:16Zen
dc.date.issued2013-05-21en
dc.identifier.issn2040-3364en
dc.identifier.issn2040-3372en
dc.identifier.doi10.1039/c3nr01530ken
dc.identifier.urihttp://hdl.handle.net/10754/575892en
dc.description.abstractLanthanide-doped core-shell upconversion nanocrystals (UCNCs) have tremendous potential for applications in many fields, especially in bio-imaging and medical therapy. As core-shell UCNCs are mostly synthesized in organic solvents, tedious organic-aqueous phase transfer processes are usually needed for their use in bio-applications. Herein, we demonstrate the first example of one-step synthesis of highly luminescent core-shell UCNCs in the "aqueous" phase under mild conditions using innocuous reagents. A microwave-assisted approach allowed for layer-by-layer epitaxial growth of a hydrophilic NaGdF4 shell on NaYF4:Yb, Er cores. During this process, surface defects of the nanocrystals could be gradually passivated by the homogeneous shell deposition, resulting in obvious enhancement in the overall upconversion emission efficiency. In addition, the up-down conversion dual-mode luminescent NaYF4:Yb, Er@NaGdF4:Ce, Ln (Eu, Tb, Sm, Dy) nanocrystals were also synthesized to further validate the successful formation of the core-shell structure. More significantly, based on their superior solubility and stability in water solution, high upconversion efficiency and Gd-doped predominant X-ray absorption, the as-prepared NaYF4:Yb, Er@NaGdF4 core-shell UCNCs exhibited high contrast in in vitro cell imaging and in vivo X-ray computed tomography (CT) imaging, demonstrating great potential as multiplexed luminescent biolabels and CT contrast agents.en
dc.description.sponsorshipThis work was supported by the Foundation of the National Natural Science Foundation of China (no. 20971054, 90922034 and 21131002), Specialized Research Fund for the Doctoral Program of Higher Education (no. 20110061110015), National High Technology Research and Develop Program (863 program) of China (no. 2013AA031702) and the Special Program of China Postdoctoral Science Foundation (no. 2012T50288). X. G. Kong would like to thank the NSF of china (no. 11174277 and 61275202). ESI is available online from Wiley InterScience or from the author.en
dc.publisherRoyal Society of Chemistry (RSC)en
dc.titleAqueous phase synthesis of upconversion nanocrystals through layer-by-layer epitaxial growth for in vivo X-ray computed tomographyen
dc.typeArticleen
dc.contributor.departmentCore Labsen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.contributor.departmentChemical Science Programen
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Centeren
dc.contributor.departmentChemical Science Programen
dc.contributor.departmentNanostructured Functional Materials (NFM) laboratoryen
dc.contributor.departmentCore Labsen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.contributor.departmentChemical Science Programen
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Centeren
dc.contributor.departmentChemical Science Programen
dc.contributor.departmentNanostructured Functional Materials (NFM) laboratoryen
dc.identifier.journalNanoscaleen
dc.contributor.institutionJilin Univ, State Key Lab Inorgan Synth & Preparat Chem, Coll Chem, Changchun 130012, Peoples R Chinaen
dc.contributor.institutionJilin Univ, Dept Radiol, Hosp 2, Changchun 130022, Peoples R Chinaen
dc.contributor.institutionChinese Acad Sci, State Key Lab Luminescence & Applicat, Changchun Inst Opt Fine Mech & Phys, Changchun 130033, Peoples R Chinaen
kaust.authorZhao, Lanen
kaust.authorHan, Yuen
kaust.authorZhao, Lanen
kaust.authorHan, Yuen
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