Effects of Mechanical Properties on Tumor Invasion: Insights from a Cellular Model

Handle URI:
http://hdl.handle.net/10754/575824
Title:
Effects of Mechanical Properties on Tumor Invasion: Insights from a Cellular Model
Authors:
Li, YZ; Naveed, H; Liang, J; Xu, LX
Abstract:
Understanding the regulating mechanism of tumor invasion is of crucial importance for both fundamental cancer research and clinical applications. Previous in vivo experiments have shown that invasive cancer cells dissociate from the primary tumor and invade into the stroma, forming an irregular invasive morphology. Although cell movements involved in tumor invasion are ultimately driven by mechanical forces of cell-cell interactions and tumor-host interactions, how these mechanical properties affect tumor invasion is still poorly understood. In this study, we use a recently developed two-dimensional cellular model to study the effects of mechanical properties on tumor invasion. We study the effects of cell-cell adhesions as well as the degree of degradation and stiffness of extracellular matrix (ECM). Our simulation results show that cell-cell adhesion relationship must be satisfied for tumor invasion. Increased adhesion to ECM and decreased adhesion among tumor cells result in invasive tumor behaviors. When this invasive behavior occurs, ECM plays an important role for both tumor morphology and the shape of invasive cancer cells. Increased stiffness and stronger degree of degradation of ECM promote tumor invasion, generating more aggressive tumor invasive morphologies. It can also generate irregular shape of invasive cancer cells, protruding towards ECM. The capability of our model suggests it a useful tool to study tumor invasion and might be used to propose optimal treatment in clinical applications.
KAUST Department:
Computer Science Program
Publisher:
Institute of Electrical and Electronics Engineers (IEEE)
Journal:
2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Conference/Event name:
Engineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE
Issue Date:
Aug-2014
DOI:
10.1109/EMBC.2014.6945194
Type:
Conference Paper
ISSN:
1557-170X
ISBN:
978-1-4244-7929-0
Appears in Collections:
Conference Papers; Computer Science Program; Computer Science Program; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorLi, YZen
dc.contributor.authorNaveed, Hen
dc.contributor.authorLiang, Jen
dc.contributor.authorXu, LXen
dc.date.accessioned2015-08-24T09:27:10Zen
dc.date.available2015-08-24T09:27:10Zen
dc.date.issued2014-08en
dc.identifier.isbn978-1-4244-7929-0en
dc.identifier.issn1557-170Xen
dc.identifier.doi10.1109/EMBC.2014.6945194en
dc.identifier.urihttp://hdl.handle.net/10754/575824en
dc.description.abstractUnderstanding the regulating mechanism of tumor invasion is of crucial importance for both fundamental cancer research and clinical applications. Previous in vivo experiments have shown that invasive cancer cells dissociate from the primary tumor and invade into the stroma, forming an irregular invasive morphology. Although cell movements involved in tumor invasion are ultimately driven by mechanical forces of cell-cell interactions and tumor-host interactions, how these mechanical properties affect tumor invasion is still poorly understood. In this study, we use a recently developed two-dimensional cellular model to study the effects of mechanical properties on tumor invasion. We study the effects of cell-cell adhesions as well as the degree of degradation and stiffness of extracellular matrix (ECM). Our simulation results show that cell-cell adhesion relationship must be satisfied for tumor invasion. Increased adhesion to ECM and decreased adhesion among tumor cells result in invasive tumor behaviors. When this invasive behavior occurs, ECM plays an important role for both tumor morphology and the shape of invasive cancer cells. Increased stiffness and stronger degree of degradation of ECM promote tumor invasion, generating more aggressive tumor invasive morphologies. It can also generate irregular shape of invasive cancer cells, protruding towards ECM. The capability of our model suggests it a useful tool to study tumor invasion and might be used to propose optimal treatment in clinical applications.en
dc.publisherInstitute of Electrical and Electronics Engineers (IEEE)en
dc.titleEffects of Mechanical Properties on Tumor Invasion: Insights from a Cellular Modelen
dc.typeConference Paperen
dc.contributor.departmentComputer Science Programen
dc.identifier.journal2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Societyen
dc.conference.date26-30 Aug. 2014en
dc.conference.nameEngineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEEen
dc.conference.locationChicago, ILen
dc.contributor.institutionShanghai Jiao Tong Univ, Sch Biomed Engn, Shanghai 200030, Peoples R Chinaen
dc.contributor.institutionShanghai Jiao Tong Univ, Med X Res Inst, Shanghai 200030, Peoples R Chinaen
dc.contributor.institutionUniv Illinois, Dept Bioengn, Chicago, IL 60607 USAen
dc.contributor.institutionShanghai Jiao Tong Univ, Shanghai Ctr Syst Biomed, Shanghai 200240, Peoples R Chinaen
kaust.authorNaveed, Hammaden
All Items in KAUST are protected by copyright, with all rights reserved, unless otherwise indicated.