Potent antifouling compounds produced by marine Streptomyces

Handle URI:
http://hdl.handle.net/10754/575668
Title:
Potent antifouling compounds produced by marine Streptomyces
Authors:
Xu, Ying; He, Hongping; Schulz, Stefan; Liu, Xin; Fusetani, Nobushino; Xiong, Hairong; Xiao, Xiang; Qian, Peiyuan
Abstract:
Biofouling causes huge economic loss and a recent global ban on organotin compounds as antifouling agents has increased the need for safe and effective antifouling compounds. Five structurally similar compounds were isolated from the crude extract of a marine Streptomyces strain obtained from deep-sea sediments. Antifouling activities of these five compounds and four other structurally-related compounds isolated from a North Sea Streptomyces strain against major fouling organisms were compared to probe structure-activity relationships of compounds. The functional moiety responsible for antifouling activity lies in the 2-furanone ring and that the lipophilicity of compounds substantially affects their antifouling activities. Based on these findings, a compound with a straight alkyl side-chain was synthesized and proved itself as a very effective non-toxic, anti-larval settlement agent against three major fouling organisms. The strong antifouling activity, relatively low toxicity, and simple structures of these compounds make them promising candidates for new antifouling additives. © 2009 Elsevier Ltd. All rights reserved.
KAUST Department:
KAUST Global Partnership Program; Advanced Membranes and Porous Materials Research Center
Publisher:
Elsevier BV
Journal:
Bioresource Technology
Issue Date:
Feb-2010
DOI:
10.1016/j.biortech.2009.09.046
PubMed ID:
19818601
Type:
Article
ISSN:
09608524
Sponsors:
This work was supported by a Grant from China Ocean Mineral Resources Research and Development Association (COMRRDA06/07.Sc02), a RGC Grant (HKUST6418/06M) from the Hong Kong SAR, and a Grant from the King Abdullah University of Science & Technology Global Special Academic Partnership Program (KAUST003-CML.07/08) to PY Qjan.
Appears in Collections:
Articles; Advanced Membranes and Porous Materials Research Center

Full metadata record

DC FieldValue Language
dc.contributor.authorXu, Yingen
dc.contributor.authorHe, Hongpingen
dc.contributor.authorSchulz, Stefanen
dc.contributor.authorLiu, Xinen
dc.contributor.authorFusetani, Nobushinoen
dc.contributor.authorXiong, Hairongen
dc.contributor.authorXiao, Xiangen
dc.contributor.authorQian, Peiyuanen
dc.date.accessioned2015-08-24T08:35:26Zen
dc.date.available2015-08-24T08:35:26Zen
dc.date.issued2010-02en
dc.identifier.issn09608524en
dc.identifier.pmid19818601en
dc.identifier.doi10.1016/j.biortech.2009.09.046en
dc.identifier.urihttp://hdl.handle.net/10754/575668en
dc.description.abstractBiofouling causes huge economic loss and a recent global ban on organotin compounds as antifouling agents has increased the need for safe and effective antifouling compounds. Five structurally similar compounds were isolated from the crude extract of a marine Streptomyces strain obtained from deep-sea sediments. Antifouling activities of these five compounds and four other structurally-related compounds isolated from a North Sea Streptomyces strain against major fouling organisms were compared to probe structure-activity relationships of compounds. The functional moiety responsible for antifouling activity lies in the 2-furanone ring and that the lipophilicity of compounds substantially affects their antifouling activities. Based on these findings, a compound with a straight alkyl side-chain was synthesized and proved itself as a very effective non-toxic, anti-larval settlement agent against three major fouling organisms. The strong antifouling activity, relatively low toxicity, and simple structures of these compounds make them promising candidates for new antifouling additives. © 2009 Elsevier Ltd. All rights reserved.en
dc.description.sponsorshipThis work was supported by a Grant from China Ocean Mineral Resources Research and Development Association (COMRRDA06/07.Sc02), a RGC Grant (HKUST6418/06M) from the Hong Kong SAR, and a Grant from the King Abdullah University of Science & Technology Global Special Academic Partnership Program (KAUST003-CML.07/08) to PY Qjan.en
dc.publisherElsevier BVen
dc.subjectAntifouling compoundsen
dc.subjectBiofoulingen
dc.subjectStreptomycesen
dc.subjectStructure-activity relationshipsen
dc.titlePotent antifouling compounds produced by marine Streptomycesen
dc.typeArticleen
dc.contributor.departmentKAUST Global Partnership Programen
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Centeren
dc.identifier.journalBioresource Technologyen
dc.contributor.institutionInstitut für Organische Chemie, Technische Universität Braunschweig, Hagenring 30, D-38106 Braunschweig, Germanyen
dc.contributor.institutionDepartment of Biology, South-Central University for Nationalities, 430074 Wuhan, Chinaen
dc.contributor.institutionThe Third Institute of Oceanography, State Oceanic Administration, 361005 Xiamen, Fujian, Chinaen
kaust.authorLiu, Xinen
kaust.authorXu, Yingen
kaust.authorHe, Hongpingen
kaust.authorFusetani, Nobushinoen
kaust.authorQian, Peiyuanen
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