Synthesis of Fluoroalkoxy Substituted Arylboronic Esters by Iridium-Catalyzed Aromatic C–H Borylation

Handle URI:
http://hdl.handle.net/10754/575662
Title:
Synthesis of Fluoroalkoxy Substituted Arylboronic Esters by Iridium-Catalyzed Aromatic C–H Borylation
Authors:
Batool, Farhat; Parveen, Shehla; Emwas, Abdul-Hamid M.; Sioud, Salim; Gao, Xin ( 0000-0002-7108-3574 ) ; Munawar, Munawar A.; Chotana, Ghayoor A.
Abstract:
The preparation of fluoroalkoxy arylboronic esters by iridium-catalyzed aromatic C–H borylation is described. The fluoroalkoxy groups employed include trifluoromethoxy, difluoromethoxy, 1,1,2,2-tetrafluoroethoxy, and 2,2-difluoro-1,3-benzodioxole. The borylation reactions were carried out neat without the use of a glovebox or Schlenk line. The regioselectivities available through the iridium-catalyzed C–H borylation are complementary to those obtained by the electrophilic aromatic substitution reactions of fluoroalkoxy arenes. Fluoroalkoxy arylboronic esters can serve as versatile building blocks.
KAUST Department:
Advanced Nanofabrication, Imaging and Characterization Core Lab; Core Labs; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division; Computer Science Program; Computational Bioscience Research Center (CBRC); Computer Science Program; Structural and Functional Bioinformatics Group
Publisher:
American Chemical Society (ACS)
Journal:
Organic Letters
Issue Date:
17-Aug-2015
DOI:
10.1021/acs.orglett.5b02050
Type:
Article
ISSN:
1523-7060; 1523-7052
Appears in Collections:
Articles; Advanced Nanofabrication, Imaging and Characterization Core Lab; Structural and Functional Bioinformatics Group; Computer Science Program; Computational Bioscience Research Center (CBRC); Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorBatool, Farhaten
dc.contributor.authorParveen, Shehlaen
dc.contributor.authorEmwas, Abdul-Hamid M.en
dc.contributor.authorSioud, Salimen
dc.contributor.authorGao, Xinen
dc.contributor.authorMunawar, Munawar A.en
dc.contributor.authorChotana, Ghayoor A.en
dc.date.accessioned2015-08-24T08:35:18Zen
dc.date.available2015-08-24T08:35:18Zen
dc.date.issued2015-08-17en
dc.identifier.issn1523-7060en
dc.identifier.issn1523-7052en
dc.identifier.doi10.1021/acs.orglett.5b02050en
dc.identifier.urihttp://hdl.handle.net/10754/575662en
dc.description.abstractThe preparation of fluoroalkoxy arylboronic esters by iridium-catalyzed aromatic C–H borylation is described. The fluoroalkoxy groups employed include trifluoromethoxy, difluoromethoxy, 1,1,2,2-tetrafluoroethoxy, and 2,2-difluoro-1,3-benzodioxole. The borylation reactions were carried out neat without the use of a glovebox or Schlenk line. The regioselectivities available through the iridium-catalyzed C–H borylation are complementary to those obtained by the electrophilic aromatic substitution reactions of fluoroalkoxy arenes. Fluoroalkoxy arylboronic esters can serve as versatile building blocks.en
dc.publisherAmerican Chemical Society (ACS)en
dc.titleSynthesis of Fluoroalkoxy Substituted Arylboronic Esters by Iridium-Catalyzed Aromatic C–H Borylationen
dc.typeArticleen
dc.contributor.departmentAdvanced Nanofabrication, Imaging and Characterization Core Laben
dc.contributor.departmentCore Labsen
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Divisionen
dc.contributor.departmentComputer Science Programen
dc.contributor.departmentComputational Bioscience Research Center (CBRC)en
dc.contributor.departmentComputer Science Programen
dc.contributor.departmentStructural and Functional Bioinformatics Groupen
dc.identifier.journalOrganic Lettersen
dc.contributor.institutionDepartment of Chemistry, Syed Babar Ali School of Science & Engineering, Lahore University of Management Sciences, Lahore 54792, Pakistanen
dc.contributor.institutionInstitute of Chemistry, University of the Punjab, Lahore 54590, Pakistanen
kaust.authorEmwas, Abdul-Hamid M.en
kaust.authorSioud, Salimen
kaust.authorGao, Xinen
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