“Two-Step” Raman Imaging Technique To Guide Chemo-Photothermal Cancer Therapy

Handle URI:
http://hdl.handle.net/10754/575660
Title:
“Two-Step” Raman Imaging Technique To Guide Chemo-Photothermal Cancer Therapy
Authors:
Deng, Lin ( 0000-0001-8954-5610 ) ; Li, Qiujin; Yang, Yang; Omar, Haneen; Tang, Naijun; Zhang, Jianfei; Nie, Zhihong; Khashab, Niveen M. ( 0000-0003-2728-0666 )
Abstract:
Graphene oxide-wrapped gold nanorods (GO@AuNRs) offer efficient drug delivery as well as NIR laser photothermal therapy (PTT) in vitro and in vivo. However, no real-time observation of drug release has been reported to better understand the synergy of chemotherapy and PTT. Herein, surface-enhance Raman spectroscopy (SERS) is employed to guide chemo-photothermal cancer therapy by a two-step mechanism. In the presence of GO as an internal standard, SERS signals of DOX (doxorubicin) loaded onto GO@AuNRs are found to be pH-responsive. Both DOX and GO show strong SERS signals before the DOX@GO@AuNRs are endocytic. However, when the DOX@GO@AuNRs enter acidic microenvironments such as endosomes and/or lysosomes, the DOX signals start decreasing while the GO signals remain the same. This plasmonic antenna could be used to identify the appropriate time to apply the PTT laser during chemo-photothermal therapy.
KAUST Department:
Advanced Membranes and Porous Materials Research Center; Advanced Membranes and Porous Materials Research Center; Core Labs; Physical Sciences and Engineering (PSE) Division; Chemical Science Program; Advanced Membranes and Porous Materials Research Center; Chemical Science Program; Smart Hybrid Materials (SHMs) lab
Publisher:
Wiley-Blackwell
Journal:
Chemistry - A European Journal
Issue Date:
13-Aug-2015
DOI:
10.1002/chem.201502522
Type:
Article
ISSN:
0947-6539
Appears in Collections:
Articles; Advanced Membranes and Porous Materials Research Center; Physical Sciences and Engineering (PSE) Division; Controlled Release and Delivery Laboratory; Chemical Science Program

Full metadata record

DC FieldValue Language
dc.contributor.authorDeng, Linen
dc.contributor.authorLi, Qiujinen
dc.contributor.authorYang, Yangen
dc.contributor.authorOmar, Haneenen
dc.contributor.authorTang, Naijunen
dc.contributor.authorZhang, Jianfeien
dc.contributor.authorNie, Zhihongen
dc.contributor.authorKhashab, Niveen M.en
dc.date.accessioned2015-08-24T08:35:15Zen
dc.date.available2015-08-24T08:35:15Zen
dc.date.issued2015-08-13en
dc.identifier.issn0947-6539en
dc.identifier.doi10.1002/chem.201502522en
dc.identifier.urihttp://hdl.handle.net/10754/575660en
dc.description.abstractGraphene oxide-wrapped gold nanorods (GO@AuNRs) offer efficient drug delivery as well as NIR laser photothermal therapy (PTT) in vitro and in vivo. However, no real-time observation of drug release has been reported to better understand the synergy of chemotherapy and PTT. Herein, surface-enhance Raman spectroscopy (SERS) is employed to guide chemo-photothermal cancer therapy by a two-step mechanism. In the presence of GO as an internal standard, SERS signals of DOX (doxorubicin) loaded onto GO@AuNRs are found to be pH-responsive. Both DOX and GO show strong SERS signals before the DOX@GO@AuNRs are endocytic. However, when the DOX@GO@AuNRs enter acidic microenvironments such as endosomes and/or lysosomes, the DOX signals start decreasing while the GO signals remain the same. This plasmonic antenna could be used to identify the appropriate time to apply the PTT laser during chemo-photothermal therapy.en
dc.publisherWiley-Blackwellen
dc.title“Two-Step” Raman Imaging Technique To Guide Chemo-Photothermal Cancer Therapyen
dc.typeArticleen
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Centeren
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Centeren
dc.contributor.departmentCore Labsen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.contributor.departmentChemical Science Programen
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Centeren
dc.contributor.departmentChemical Science Programen
dc.contributor.departmentSmart Hybrid Materials (SHMs) laben
dc.identifier.journalChemistry - A European Journalen
dc.contributor.institutionSchool of Textiles, Tianjin Polytechnic University, Key Laboratory of Advanced Textile Composites, Ministry of Education, Tianjin 300387 (P. R. China)en
dc.contributor.institutionDepartment of Occupational & Environmental Health, Tianjin Medical University, Tianjin 300070 (P. R. China)en
dc.contributor.institutionDepartment of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742 (USA)en
kaust.authorDeng, Linen
kaust.authorYang, Yangen
kaust.authorKhashab, Niveen M.en
kaust.authorLi, Qiujinen
kaust.authorOmar, Haneenen
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