Regulation of neurotrophic factors and energy metabolism by antidepressants in astrocytes

Handle URI:
http://hdl.handle.net/10754/575580
Title:
Regulation of neurotrophic factors and energy metabolism by antidepressants in astrocytes
Authors:
Martin, Jean Luc; Magistretti, Pierre J. ( 0000-0002-6678-320X ) ; Allaman, Igor
Abstract:
There is growing evidence that astrocytes are involved in the neuropathology of major depression. In particular, decreases in glial cell density observed in the cerebral cortex of individuals with major depressive disorder are accompanied by a reduction of several astrocytic markers suggesting that astrocyte dysfunction may contribute to the pathophysiology of major depression. In rodents, glial loss in the prefrontal cortex is sufficient to induce depressive-like behaviors and antidepressant treatment prevents the stress-induced reduction of astrocyte number in the hippocampus. Collectively, these data support the existence of a link between astrocyte loss or dysfunction, depressive-like behavior and antidepressant treatment. Astrocytes are increasingly recognized to play important roles in neuronal development, neurotransmission, synaptic plasticity and maintenance of brain homeostasis. It is also well established that astrocytes provide trophic, structural, and metabolic support to neurons. In this article, we review evidence that antidepressants regulate energy metabolism and neurotrophic factor expression with particular emphasis on studies in astrocytes. These observations support a role for astrocytes as new targets for antidepressants. The contribution of changes in astrocyte glucose metabolism and neurotrophic factor expression to the therapeutic effects of antidepressants remains to be established. © 2013 Bentham Science Publishers.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division; Bioscience Program
Publisher:
Bentham Science Publishers Ltd.
Journal:
Current Drug Targets
Issue Date:
1-Sep-2013
DOI:
10.2174/1389450111314110009
PubMed ID:
23469874
Type:
Article
ISSN:
13894501
Appears in Collections:
Articles; Bioscience Program; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorMartin, Jean Lucen
dc.contributor.authorMagistretti, Pierre J.en
dc.contributor.authorAllaman, Igoren
dc.date.accessioned2015-08-24T08:33:23Zen
dc.date.available2015-08-24T08:33:23Zen
dc.date.issued2013-09-01en
dc.identifier.issn13894501en
dc.identifier.pmid23469874en
dc.identifier.doi10.2174/1389450111314110009en
dc.identifier.urihttp://hdl.handle.net/10754/575580en
dc.description.abstractThere is growing evidence that astrocytes are involved in the neuropathology of major depression. In particular, decreases in glial cell density observed in the cerebral cortex of individuals with major depressive disorder are accompanied by a reduction of several astrocytic markers suggesting that astrocyte dysfunction may contribute to the pathophysiology of major depression. In rodents, glial loss in the prefrontal cortex is sufficient to induce depressive-like behaviors and antidepressant treatment prevents the stress-induced reduction of astrocyte number in the hippocampus. Collectively, these data support the existence of a link between astrocyte loss or dysfunction, depressive-like behavior and antidepressant treatment. Astrocytes are increasingly recognized to play important roles in neuronal development, neurotransmission, synaptic plasticity and maintenance of brain homeostasis. It is also well established that astrocytes provide trophic, structural, and metabolic support to neurons. In this article, we review evidence that antidepressants regulate energy metabolism and neurotrophic factor expression with particular emphasis on studies in astrocytes. These observations support a role for astrocytes as new targets for antidepressants. The contribution of changes in astrocyte glucose metabolism and neurotrophic factor expression to the therapeutic effects of antidepressants remains to be established. © 2013 Bentham Science Publishers.en
dc.publisherBentham Science Publishers Ltd.en
dc.subjectAntidepressantsen
dc.subjectAstrocyte-neuron cooperationen
dc.subjectAstrocytesen
dc.subjectBDNFen
dc.subjectGlucose metabolismen
dc.subjectLactateen
dc.subjectNeurotrophic factorsen
dc.titleRegulation of neurotrophic factors and energy metabolism by antidepressants in astrocytesen
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.contributor.departmentBioscience Programen
dc.identifier.journalCurrent Drug Targetsen
dc.contributor.institutionCenter for Psychiatric Neurosciences, Department of Psychiatry-CHUV, Prilly-Lausanne, Switzerlanden
dc.contributor.institutionLaboratory of Neuroenergetics and Cellular Dynamics, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerlanden
kaust.authorMagistretti, Pierre J.en

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