Mechanistic aspects of carotenoid biosynthesis

Handle URI:
http://hdl.handle.net/10754/566130
Title:
Mechanistic aspects of carotenoid biosynthesis
Authors:
Moïse, Alexander R.; Al-Babili, Salim ( 0000-0003-4823-2882 ) ; Wurtzel, Eleanore T.
Abstract:
Carotenoid synthesis is based on the analysis of the phenotype of several mutant strains of tomato lacking carotenoid synthetic genes. Carotenoids are tetraterpenes derived through the condensation of the five-carbon (C5) universal isoprenoid precursors isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). A recently developed concept that could explain the role of the poly-cis pathway in carotenoid synthesis is that the intermediates of this pathway have additional physiological roles that extend beyond serving as precursors of lycopene. This concept is based on the analysis of the phenotype of several mutant strains of tomato lacking carotenoid synthetic genes. The feedback regulation of early carotenoid synthetic genes in response to a block in upstream metabolism represents a paradigm shift in our understanding of the mechanism and regulation of carotenoid synthesis and of metabolic regulation in general. The molecular details of a signaling pathway that regulates carotenogenesis in response to the levels of carotenoid precursors are still unclear.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division
Publisher:
American Chemical Society (ACS)
Journal:
Chemical Reviews
Issue Date:
8-Jan-2014
DOI:
10.1021/cr400106y
PubMed ID:
24175570
PubMed Central ID:
PMC3898671
Type:
Article
ISSN:
00092665
Sponsors:
The carotenoid and retinoid research in the Moise lab is supported by startup funds provided by the Department of Pharmacology and Toxicology, by a grant from the National Institutes of Health Grants 5P20RR017708-10, and a Graduate Research Fellowship from the University of Kansas. The carotenoid research in the Al-Babili lab was supported by the Deutsche Forschungsgemeinschaft (DFG) grant number AL 892/1-4. The carotenoid research in the Wurtzel lab has been funded by the U.S. National Institutes of Health, Rockefeller Foundation International Rice Biotechnology Program, McKnight Foundation, American Cancer Society, U.S. National Science Foundation, United States Department of Agriculture, PSC-CUNY, and New York State. We thank Dr. Brian Blagg, Medicinal Chemistry, University of Kansas, for critical comments and important suggestions on the manuscript. We thank Dr. Alfonso Prado-Cabrero, Center for Desert Agriculture (CDA), King Abdullah University of Science and Technology, for his contributions and suggestions for the illustration used for Cover Art and the Table of Contents.
Appears in Collections:
Articles; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorMoïse, Alexander R.en
dc.contributor.authorAl-Babili, Salimen
dc.contributor.authorWurtzel, Eleanore T.en
dc.date.accessioned2015-08-12T09:29:28Zen
dc.date.available2015-08-12T09:29:28Zen
dc.date.issued2014-01-08en
dc.identifier.issn00092665en
dc.identifier.pmid24175570en
dc.identifier.doi10.1021/cr400106yen
dc.identifier.urihttp://hdl.handle.net/10754/566130en
dc.description.abstractCarotenoid synthesis is based on the analysis of the phenotype of several mutant strains of tomato lacking carotenoid synthetic genes. Carotenoids are tetraterpenes derived through the condensation of the five-carbon (C5) universal isoprenoid precursors isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). A recently developed concept that could explain the role of the poly-cis pathway in carotenoid synthesis is that the intermediates of this pathway have additional physiological roles that extend beyond serving as precursors of lycopene. This concept is based on the analysis of the phenotype of several mutant strains of tomato lacking carotenoid synthetic genes. The feedback regulation of early carotenoid synthetic genes in response to a block in upstream metabolism represents a paradigm shift in our understanding of the mechanism and regulation of carotenoid synthesis and of metabolic regulation in general. The molecular details of a signaling pathway that regulates carotenogenesis in response to the levels of carotenoid precursors are still unclear.en
dc.description.sponsorshipThe carotenoid and retinoid research in the Moise lab is supported by startup funds provided by the Department of Pharmacology and Toxicology, by a grant from the National Institutes of Health Grants 5P20RR017708-10, and a Graduate Research Fellowship from the University of Kansas. The carotenoid research in the Al-Babili lab was supported by the Deutsche Forschungsgemeinschaft (DFG) grant number AL 892/1-4. The carotenoid research in the Wurtzel lab has been funded by the U.S. National Institutes of Health, Rockefeller Foundation International Rice Biotechnology Program, McKnight Foundation, American Cancer Society, U.S. National Science Foundation, United States Department of Agriculture, PSC-CUNY, and New York State. We thank Dr. Brian Blagg, Medicinal Chemistry, University of Kansas, for critical comments and important suggestions on the manuscript. We thank Dr. Alfonso Prado-Cabrero, Center for Desert Agriculture (CDA), King Abdullah University of Science and Technology, for his contributions and suggestions for the illustration used for Cover Art and the Table of Contents.en
dc.publisherAmerican Chemical Society (ACS)en
dc.titleMechanistic aspects of carotenoid biosynthesisen
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.identifier.journalChemical Reviewsen
dc.identifier.pmcidPMC3898671en
dc.contributor.institutionDepartment of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, KS 66045, United Statesen
dc.contributor.institutionDepartment of Biological Sciences, Lehman College, City University of New York, Bronx, NY 10468, United Statesen
dc.contributor.institutionGraduate School and University Center, City University of New York, 365 Fifth Ave., New York, NY 10016, United Statesen
kaust.authorAl-Babili, Salimen
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