A Cellular Perspective on Brain Energy Metabolism and Functional Imaging

Handle URI:
http://hdl.handle.net/10754/566059
Title:
A Cellular Perspective on Brain Energy Metabolism and Functional Imaging
Authors:
Magistretti, Pierre J. ( 0000-0002-6678-320X ) ; Allaman, Igor
Abstract:
The energy demands of the brain are high: they account for at least 20% of the body's energy consumption. Evolutionary studies indicate that the emergence of higher cognitive functions in humans is associated with an increased glucose utilization and expression of energy metabolism genes. Functional brain imaging techniques such as fMRI and PET, which are widely used in human neuroscience studies, detect signals that monitor energy delivery and use in register with neuronal activity. Recent technological advances in metabolic studies with cellular resolution have afforded decisive insights into the understanding of the cellular and molecular bases of the coupling between neuronal activity and energy metabolism and pointat a key role of neuron-astrocyte metabolic interactions. This article reviews some of the most salient features emerging from recent studies and aims at providing an integration of brain energy metabolism across resolution scales. © 2015 Elsevier Inc.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division
Publisher:
Elsevier BV
Journal:
Neuron
Issue Date:
May-2015
DOI:
10.1016/j.neuron.2015.03.035
Type:
Article
ISSN:
08966273
Sponsors:
Research on brain energy metabolism in P.J.M.'s laboratory has been supported over the years by the Swiss National Science Foundation and by the University of Lausanne, EPFL, CHUV, the NCCR Synapsy, the Biaggi and Panacee foundations, and KAUST. The authors wish to thank Ivan Gromiko and Heno Hwang for their support in drawing figures and Virginia Unkefer for editorial review, all of the academic writing services at KAUST. For the section on evolution, the authors are grateful to Dr. Alain Prochiantz for pointing out some key references and to Dr. Patrick Hof for critical reading.
Appears in Collections:
Articles; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorMagistretti, Pierre J.en
dc.contributor.authorAllaman, Igoren
dc.date.accessioned2015-08-12T09:26:31Zen
dc.date.available2015-08-12T09:26:31Zen
dc.date.issued2015-05en
dc.identifier.issn08966273en
dc.identifier.doi10.1016/j.neuron.2015.03.035en
dc.identifier.urihttp://hdl.handle.net/10754/566059en
dc.description.abstractThe energy demands of the brain are high: they account for at least 20% of the body's energy consumption. Evolutionary studies indicate that the emergence of higher cognitive functions in humans is associated with an increased glucose utilization and expression of energy metabolism genes. Functional brain imaging techniques such as fMRI and PET, which are widely used in human neuroscience studies, detect signals that monitor energy delivery and use in register with neuronal activity. Recent technological advances in metabolic studies with cellular resolution have afforded decisive insights into the understanding of the cellular and molecular bases of the coupling between neuronal activity and energy metabolism and pointat a key role of neuron-astrocyte metabolic interactions. This article reviews some of the most salient features emerging from recent studies and aims at providing an integration of brain energy metabolism across resolution scales. © 2015 Elsevier Inc.en
dc.description.sponsorshipResearch on brain energy metabolism in P.J.M.'s laboratory has been supported over the years by the Swiss National Science Foundation and by the University of Lausanne, EPFL, CHUV, the NCCR Synapsy, the Biaggi and Panacee foundations, and KAUST. The authors wish to thank Ivan Gromiko and Heno Hwang for their support in drawing figures and Virginia Unkefer for editorial review, all of the academic writing services at KAUST. For the section on evolution, the authors are grateful to Dr. Alain Prochiantz for pointing out some key references and to Dr. Patrick Hof for critical reading.en
dc.publisherElsevier BVen
dc.titleA Cellular Perspective on Brain Energy Metabolism and Functional Imagingen
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.identifier.journalNeuronen
dc.contributor.institutionLaboratory of Neuroenergetics and Cellular Dynamics, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerlanden
dc.contributor.institutionCenter for Psychiatric Neurosciences, Department of Psychiatry, University of Lausanne, Lausanne, Switzerlanden
kaust.authorMagistretti, Pierre J.en
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