Plant transducers of the endoplasmic reticulum unfolded protein response

Handle URI:
http://hdl.handle.net/10754/566016
Title:
Plant transducers of the endoplasmic reticulum unfolded protein response
Authors:
Iwata, Yuji; Koizumi, Nozomu
Abstract:
The unfolded protein response (UPR) activates a set of genes to overcome accumulation of unfolded proteins in the endoplasmic reticulum (ER), a condition termed ER stress, and constitutes an essential part of ER protein quality control that ensures efficient maturation of secretory and membrane proteins in eukaryotes. Recent studies on Arabidopsis and rice identified the signaling pathway in which the ER membrane-localized ribonuclease IRE1 (inositol-requiring enzyme 1) catalyzes unconventional cytoplasmic splicing of mRNA, thereby producing the active transcription factor Arabidopsis bZIP60 (basic leucine zipper 60) and its ortholog in rice. Here we review recent findings identifying the molecular components of the plant UPR, including IRE1/bZIP60 and the membrane-bound transcription factors bZIP17 and bZIP28, and implicating its importance in several physiological phenomena such as pathogen response. © 2012 Elsevier Ltd.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division
Publisher:
Elsevier BV
Journal:
Trends in Plant Science
Issue Date:
Dec-2012
DOI:
10.1016/j.tplants.2012.06.014
PubMed ID:
22796463
Type:
Article
ISSN:
13601385
Appears in Collections:
Articles; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorIwata, Yujien
dc.contributor.authorKoizumi, Nozomuen
dc.date.accessioned2015-08-12T08:59:34Zen
dc.date.available2015-08-12T08:59:34Zen
dc.date.issued2012-12en
dc.identifier.issn13601385en
dc.identifier.pmid22796463en
dc.identifier.doi10.1016/j.tplants.2012.06.014en
dc.identifier.urihttp://hdl.handle.net/10754/566016en
dc.description.abstractThe unfolded protein response (UPR) activates a set of genes to overcome accumulation of unfolded proteins in the endoplasmic reticulum (ER), a condition termed ER stress, and constitutes an essential part of ER protein quality control that ensures efficient maturation of secretory and membrane proteins in eukaryotes. Recent studies on Arabidopsis and rice identified the signaling pathway in which the ER membrane-localized ribonuclease IRE1 (inositol-requiring enzyme 1) catalyzes unconventional cytoplasmic splicing of mRNA, thereby producing the active transcription factor Arabidopsis bZIP60 (basic leucine zipper 60) and its ortholog in rice. Here we review recent findings identifying the molecular components of the plant UPR, including IRE1/bZIP60 and the membrane-bound transcription factors bZIP17 and bZIP28, and implicating its importance in several physiological phenomena such as pathogen response. © 2012 Elsevier Ltd.en
dc.publisherElsevier BVen
dc.titlePlant transducers of the endoplasmic reticulum unfolded protein responseen
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.identifier.journalTrends in Plant Scienceen
dc.contributor.institutionGraduate School of Life and Environmental Sciences, Osaka Prefecture University, 599-8531, Sakai, Japanen
kaust.authorIwata, Yujien

Related articles on PubMed

All Items in KAUST are protected by copyright, with all rights reserved, unless otherwise indicated.