Optical force on diseased blood cells: Towards the optical sorting of biological matter

Handle URI:
http://hdl.handle.net/10754/566009
Title:
Optical force on diseased blood cells: Towards the optical sorting of biological matter
Authors:
Gongora, J. S. Totero ( 0000-0003-2300-4218 ) ; Fratalocchi, Andrea ( 0000-0001-6769-4439 )
Abstract:
By employing a series of massively parallel ab-initio simulations, we study how optical forces act on biological matter subject to morphological disease. As a representative case study, we here consider the case of Plasmodium falciparum on red blood cells (RBC) illuminated by a monochromatic plane wave. Realistic parameters for the geometry and the refractive index are then taken from published experiments. In our theoretical campaign, we study the dependence of the optical force on the disease stage for different incident wavelengths. We show that optical forces change significantly with the disease, with amplitude variation in the hundreds of pN range. Our results open up new avenues for the design of new optical systems for the treatment of human disease. © 2015 Elsevier Ltd.
KAUST Department:
Applied Mathematics and Computational Science Program; Electrical Engineering Program; PRIMALIGHT Research Group
Publisher:
Elsevier BV
Journal:
Optics and Lasers in Engineering
Issue Date:
May-2015
DOI:
10.1016/j.optlaseng.2015.04.019
Type:
Article
ISSN:
01438166
Appears in Collections:
Articles; Applied Mathematics and Computational Science Program; PRIMALIGHT Research Group; Electrical Engineering Program

Full metadata record

DC FieldValue Language
dc.contributor.authorGongora, J. S. Toteroen
dc.contributor.authorFratalocchi, Andreaen
dc.date.accessioned2015-08-12T08:59:13Zen
dc.date.available2015-08-12T08:59:13Zen
dc.date.issued2015-05en
dc.identifier.issn01438166en
dc.identifier.doi10.1016/j.optlaseng.2015.04.019en
dc.identifier.urihttp://hdl.handle.net/10754/566009en
dc.description.abstractBy employing a series of massively parallel ab-initio simulations, we study how optical forces act on biological matter subject to morphological disease. As a representative case study, we here consider the case of Plasmodium falciparum on red blood cells (RBC) illuminated by a monochromatic plane wave. Realistic parameters for the geometry and the refractive index are then taken from published experiments. In our theoretical campaign, we study the dependence of the optical force on the disease stage for different incident wavelengths. We show that optical forces change significantly with the disease, with amplitude variation in the hundreds of pN range. Our results open up new avenues for the design of new optical systems for the treatment of human disease. © 2015 Elsevier Ltd.en
dc.publisherElsevier BVen
dc.subjectDiseased red-blood cellsen
dc.subjectFinite-Difference Time-Domainen
dc.subjectOptical forcesen
dc.titleOptical force on diseased blood cells: Towards the optical sorting of biological matteren
dc.typeArticleen
dc.contributor.departmentApplied Mathematics and Computational Science Programen
dc.contributor.departmentElectrical Engineering Programen
dc.contributor.departmentPRIMALIGHT Research Groupen
dc.identifier.journalOptics and Lasers in Engineeringen
kaust.authorFratalocchi, Andreaen
kaust.authorGongora, J. S. Toteroen
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