McClintock's challenge in the 21st century

Handle URI:
http://hdl.handle.net/10754/565994
Title:
McClintock's challenge in the 21st century
Authors:
Fedoroff, Nina V.
Abstract:
In 1950, Barbara McClintock published a Classic PNAS article, "The origin and behavior of mutable loci in maize," which summarized the evidence leading to her discovery of transposition. The article described a number of genome alterations revealed through her studies of the Dissociation locus, the first mobile genetic element she identified. McClintock described the suite of nuclear events, including transposon activation and various chromosome aberrations and rearrangements, that unfolded in the wake of genetic crosses that brought together two broken chromosomes 9. McClintock left future generations with the challenge of understanding how genomes respond to genetic and environmental stresses by mounting adaptive responses that frequently include genome restructuring.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division
Publisher:
Proceedings of the National Academy of Sciences
Journal:
Proceedings of the National Academy of Sciences
Issue Date:
13-Nov-2012
DOI:
10.1073/pnas.1215482109
PubMed ID:
23150590
PubMed Central ID:
PMC3528499
Type:
Article
ISSN:
00278424
Appears in Collections:
Articles; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorFedoroff, Nina V.en
dc.date.accessioned2015-08-12T08:58:33Zen
dc.date.available2015-08-12T08:58:33Zen
dc.date.issued2012-11-13en
dc.identifier.issn00278424en
dc.identifier.pmid23150590en
dc.identifier.doi10.1073/pnas.1215482109en
dc.identifier.urihttp://hdl.handle.net/10754/565994en
dc.description.abstractIn 1950, Barbara McClintock published a Classic PNAS article, "The origin and behavior of mutable loci in maize," which summarized the evidence leading to her discovery of transposition. The article described a number of genome alterations revealed through her studies of the Dissociation locus, the first mobile genetic element she identified. McClintock described the suite of nuclear events, including transposon activation and various chromosome aberrations and rearrangements, that unfolded in the wake of genetic crosses that brought together two broken chromosomes 9. McClintock left future generations with the challenge of understanding how genomes respond to genetic and environmental stresses by mounting adaptive responses that frequently include genome restructuring.en
dc.publisherProceedings of the National Academy of Sciencesen
dc.titleMcClintock's challenge in the 21st centuryen
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.identifier.journalProceedings of the National Academy of Sciencesen
dc.identifier.pmcidPMC3528499en
dc.contributor.institutionHuck Institutes of the Life Sciences, Penn State University, University Park, PA 16802, United Statesen
kaust.authorFedoroff, Nina V.en

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