Anti-cancer activities of diospyrin, its derivatives and analogues

Handle URI:
http://hdl.handle.net/10754/565955
Title:
Anti-cancer activities of diospyrin, its derivatives and analogues
Authors:
Sagar, Sunil; Kaur, Mandeep; Minneman, Kenneth P.; Bajic, Vladimir B. ( 0000-0001-5435-4750 )
Abstract:
Natural products have played a vital role in drug discovery and development process for cancer. Diospyrin, a plant based bisnaphthoquinonoid, has been used as a lead molecule in an effort to develop anti-cancer drugs. Several derivatives/analogues have been synthesized and screened for their pro-apoptotic/anti-cancer activities so far. Our review is focused on the pro-apoptotic/anti-cancer activities of diospyrin, its derivatives/analogues and the different mechanisms potentially involved in the bioactivity of these compounds. Particular focus has been placed on the different mechanisms (both chemical and molecular) thought to underlie the bioactivity of these compounds. A brief bioinformatics analysis at the end of the article provides novel insights into the new potential mechanisms and pathways by which these compounds might exert their effects and lead to a better realization of the full therapeutic potential of these compounds as anti-cancer drugs. © 2010 Elsevier Masson SAS. All rights reserved.
KAUST Department:
Computational Bioscience Research Center (CBRC)
Publisher:
Elsevier BV
Journal:
European Journal of Medicinal Chemistry
Issue Date:
Sep-2010
DOI:
10.1016/j.ejmech.2010.06.021
PubMed ID:
20615584
Type:
Article
ISSN:
02235234
Appears in Collections:
Articles; Computational Bioscience Research Center (CBRC)

Full metadata record

DC FieldValue Language
dc.contributor.authorSagar, Sunilen
dc.contributor.authorKaur, Mandeepen
dc.contributor.authorMinneman, Kenneth P.en
dc.contributor.authorBajic, Vladimir B.en
dc.date.accessioned2015-08-12T08:56:42Zen
dc.date.available2015-08-12T08:56:42Zen
dc.date.issued2010-09en
dc.identifier.issn02235234en
dc.identifier.pmid20615584en
dc.identifier.doi10.1016/j.ejmech.2010.06.021en
dc.identifier.urihttp://hdl.handle.net/10754/565955en
dc.description.abstractNatural products have played a vital role in drug discovery and development process for cancer. Diospyrin, a plant based bisnaphthoquinonoid, has been used as a lead molecule in an effort to develop anti-cancer drugs. Several derivatives/analogues have been synthesized and screened for their pro-apoptotic/anti-cancer activities so far. Our review is focused on the pro-apoptotic/anti-cancer activities of diospyrin, its derivatives/analogues and the different mechanisms potentially involved in the bioactivity of these compounds. Particular focus has been placed on the different mechanisms (both chemical and molecular) thought to underlie the bioactivity of these compounds. A brief bioinformatics analysis at the end of the article provides novel insights into the new potential mechanisms and pathways by which these compounds might exert their effects and lead to a better realization of the full therapeutic potential of these compounds as anti-cancer drugs. © 2010 Elsevier Masson SAS. All rights reserved.en
dc.publisherElsevier BVen
dc.subjectAnti-canceren
dc.subjectApoptosisen
dc.subjectDiospyrinen
dc.subjectQuinoneen
dc.subjectReactive oxygen speciesen
dc.titleAnti-cancer activities of diospyrin, its derivatives and analoguesen
dc.typeArticleen
dc.contributor.departmentComputational Bioscience Research Center (CBRC)en
dc.identifier.journalEuropean Journal of Medicinal Chemistryen
kaust.authorSagar, Sunilen
kaust.authorKaur, Mandeepen
kaust.authorBajic, Vladimir B.en
kaust.authorMinneman, Kenneth P.en

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