ABA receptors: The START of a new paradigm in phytohormone signalling

Handle URI:
http://hdl.handle.net/10754/565950
Title:
ABA receptors: The START of a new paradigm in phytohormone signalling
Authors:
Klingler, John ( 0000-0003-3951-9734 ) ; Batelli, Georgia; Zhu, Jian-Kang
Abstract:
The phytohormone abscisic acid (ABA) plays a central role in plant development and in plant adaptation to both biotic and abiotic stressors. In recent years, knowledge of ABA metabolism and signal transduction has advanced rapidly to provide detailed glimpses of the hormone's activities at the molecular level. Despite this progress, many gaps in understanding have remained, particularly at the early stages of ABA perception by the plant cell. The search for an ABA receptor protein has produced multiple candidates, including GCR2, GTG1, and GTG2, and CHLH. In addition to these candidates, in 2009 several research groups converged on a novel family of Arabidopsis proteins that bind ABA, and thereby interact directly with a class of protein phosphatases that are well known as critical players in ABA signal transduction. The PYR/PYL/RCAR receptor family is homologous to the Bet v 1-fold and START domain proteins. It consists of 14 members, nearly all of which appear capable of participating in an ABA receptor-signal complex that responds to the hormone by activating the transcription of ABA-responsive genes. Evidence is provided here that PYR/PYL/RCAR receptors can also drive the phosphorylation of the slow anion channel SLAC1 to provide a fast and timely response to the ABA signal. Crystallographic studies have vividly shown the mechanics of ABA binding to PYR/PYL/RCAR receptors, presenting a model that bears some resemblance to the binding of gibberellins to GID1 receptors. Since this ABA receptor family is highly conserved in crop species, its discovery is likely to usher a new wave of progress in the elucidation and manipulation of plant stress responses in agricultural settings. © 2010 The Author(s).
KAUST Department:
Center for Desert Agriculture
Publisher:
Oxford University Press (OUP)
Journal:
Journal of Experimental Botany
Issue Date:
3-Jun-2010
DOI:
10.1093/jxb/erq151
PubMed ID:
20522527
PubMed Central ID:
PMC3107536
Type:
Article
ISSN:
00220957
Appears in Collections:
Articles; Center for Desert Agriculture

Full metadata record

DC FieldValue Language
dc.contributor.authorKlingler, Johnen
dc.contributor.authorBatelli, Georgiaen
dc.contributor.authorZhu, Jian-Kangen
dc.date.accessioned2015-08-12T08:56:27Zen
dc.date.available2015-08-12T08:56:27Zen
dc.date.issued2010-06-03en
dc.identifier.issn00220957en
dc.identifier.pmid20522527en
dc.identifier.doi10.1093/jxb/erq151en
dc.identifier.urihttp://hdl.handle.net/10754/565950en
dc.description.abstractThe phytohormone abscisic acid (ABA) plays a central role in plant development and in plant adaptation to both biotic and abiotic stressors. In recent years, knowledge of ABA metabolism and signal transduction has advanced rapidly to provide detailed glimpses of the hormone's activities at the molecular level. Despite this progress, many gaps in understanding have remained, particularly at the early stages of ABA perception by the plant cell. The search for an ABA receptor protein has produced multiple candidates, including GCR2, GTG1, and GTG2, and CHLH. In addition to these candidates, in 2009 several research groups converged on a novel family of Arabidopsis proteins that bind ABA, and thereby interact directly with a class of protein phosphatases that are well known as critical players in ABA signal transduction. The PYR/PYL/RCAR receptor family is homologous to the Bet v 1-fold and START domain proteins. It consists of 14 members, nearly all of which appear capable of participating in an ABA receptor-signal complex that responds to the hormone by activating the transcription of ABA-responsive genes. Evidence is provided here that PYR/PYL/RCAR receptors can also drive the phosphorylation of the slow anion channel SLAC1 to provide a fast and timely response to the ABA signal. Crystallographic studies have vividly shown the mechanics of ABA binding to PYR/PYL/RCAR receptors, presenting a model that bears some resemblance to the binding of gibberellins to GID1 receptors. Since this ABA receptor family is highly conserved in crop species, its discovery is likely to usher a new wave of progress in the elucidation and manipulation of plant stress responses in agricultural settings. © 2010 The Author(s).en
dc.publisherOxford University Press (OUP)en
dc.subjectAbiotic stressen
dc.subjectAbscisic aciden
dc.subjectBet v 1-folden
dc.subjectDroughten
dc.subjectPP2Cen
dc.subjectPYR/PYL/RCARen
dc.subjectSalinityen
dc.subjectSignal-receptoren
dc.subjectSnRKen
dc.subjectSTART domainen
dc.titleABA receptors: The START of a new paradigm in phytohormone signallingen
dc.typeArticleen
dc.contributor.departmentCenter for Desert Agricultureen
dc.identifier.journalJournal of Experimental Botanyen
dc.identifier.pmcidPMC3107536en
dc.contributor.institutionDepartment of Botany and Plant Sciences, 2150 Batchelor Hall, University of California at Riverside, Riverside, CA 92521, United Statesen
kaust.authorKlingler, Johnen
kaust.authorBatelli, Georgiaen
kaust.authorZhu, Jian-Kangen

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