A viral suppressor protein inhibits host RNA silencing by hooking up with Argonautes

Handle URI:
http://hdl.handle.net/10754/565949
Title:
A viral suppressor protein inhibits host RNA silencing by hooking up with Argonautes
Authors:
Jin, Hailing; Zhu, Jian-Kang
Abstract:
RNA viruses are particularly vulnerable to RNAi-based defenses in the host, and thus have evolved specific proteins, known as viral suppressors of RNA silencing (VSRs), as a counterdefense. In this issue of Genes & Development, Azevedo and colleagues (pp. 904-915) discovered that P38, the VSR of Turnip crinkle virus, uses its glycine/tryptophane (GW) motifs as an ARGONAUTE (AGO) hook to attract and disarm the host's essential effector of RNA silencing. Several GW motif-containing cellular proteins are known to be important partners of AGOs in RNA silencing effector complexes in yeast, plants, and animals. The GW motif appears to be a versatile and effective tool for regulating the activities of RNA silencing pathways, and the use of GW mimicry to compete for and inhibit host AGOs may be a strategy used by many pathogens to counteract host RNAi-based defenses. © 2010 by Cold Spring Harbor Laboratory Press.
KAUST Department:
Center for Desert Agriculture
Publisher:
Cold Spring Harbor Laboratory Press
Journal:
Genes & Development
Issue Date:
1-May-2010
DOI:
10.1101/gad.1927310
PubMed ID:
20439425
PubMed Central ID:
PMC2861183
Type:
Article
ISSN:
08909369
Sponsors:
The work in H.J.'s laboratory is supported by National Institutes of Health grant GM093008 and National Science Foundation Career grant MCB-0642843. The work in J.K.Z.'s laboratory is supported by grants from National Institutes of Health, National Science Foundation, and U.S. Department of Agriculture.
Appears in Collections:
Articles; Center for Desert Agriculture

Full metadata record

DC FieldValue Language
dc.contributor.authorJin, Hailingen
dc.contributor.authorZhu, Jian-Kangen
dc.date.accessioned2015-08-12T08:56:25Zen
dc.date.available2015-08-12T08:56:25Zen
dc.date.issued2010-05-01en
dc.identifier.issn08909369en
dc.identifier.pmid20439425en
dc.identifier.doi10.1101/gad.1927310en
dc.identifier.urihttp://hdl.handle.net/10754/565949en
dc.description.abstractRNA viruses are particularly vulnerable to RNAi-based defenses in the host, and thus have evolved specific proteins, known as viral suppressors of RNA silencing (VSRs), as a counterdefense. In this issue of Genes & Development, Azevedo and colleagues (pp. 904-915) discovered that P38, the VSR of Turnip crinkle virus, uses its glycine/tryptophane (GW) motifs as an ARGONAUTE (AGO) hook to attract and disarm the host's essential effector of RNA silencing. Several GW motif-containing cellular proteins are known to be important partners of AGOs in RNA silencing effector complexes in yeast, plants, and animals. The GW motif appears to be a versatile and effective tool for regulating the activities of RNA silencing pathways, and the use of GW mimicry to compete for and inhibit host AGOs may be a strategy used by many pathogens to counteract host RNAi-based defenses. © 2010 by Cold Spring Harbor Laboratory Press.en
dc.description.sponsorshipThe work in H.J.'s laboratory is supported by National Institutes of Health grant GM093008 and National Science Foundation Career grant MCB-0642843. The work in J.K.Z.'s laboratory is supported by grants from National Institutes of Health, National Science Foundation, and U.S. Department of Agriculture.en
dc.publisherCold Spring Harbor Laboratory Pressen
dc.subjectArgonauteen
dc.subjectGW motifen
dc.subjectTCVen
dc.subjectViral suppressoren
dc.titleA viral suppressor protein inhibits host RNA silencing by hooking up with Argonautesen
dc.typeArticleen
dc.contributor.departmentCenter for Desert Agricultureen
dc.identifier.journalGenes & Developmenten
dc.identifier.pmcidPMC2861183en
dc.contributor.institutionInstitute for Integrative Genome Biology, University of California at Riverside, Riverside, CA 92521, United Statesen
dc.contributor.institutionDepartment of Plant Pathology and Microbiology, University of California at Riverside, Riverside, CA 92521, United Statesen
dc.contributor.institutionDepartment of Botany and Plant Sciences, University of California at Riverside, Riverside, CA 92521, United Statesen
kaust.authorZhu, Jian-Kangen

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