A promoter-level mammalian expression atlas

Handle URI:
http://hdl.handle.net/10754/565944
Title:
A promoter-level mammalian expression atlas
Authors:
Forest, Alistair R R; Kawaji, Hideya; Rehli, Michael; Baillie, John Kenneth; De Hoon, Michiel Jl L; Haberle, Vanja; Lassmann, Timo; Kulakovskiy, Ivan V.; Lizio, Marina; Itoh, Masayoshi; Andersson, Robin; Iida, Kei; Ikawa, Tomokatsu; Jankovic, Boris R.; Jia, Hui; Joshi, Anagha Madhusudan; Jurman, Giuseppe; Kaczkowski, Bogumił; Kai, Chieko; Kaida, Kaoru; Kaiho, Ai; Mungall, Christopher J.; Kajiyama, Kazuhiro; Kanamori-Katayama, Mutsumi; Kasianov, Artem S.; Kasukawa, Takeya; Katayama, Shintaro; Kato, Sachi; Kawaguchi, Shuji; Kawamoto, Hiroshi; Kawamura, Yuki I.; Kawashima, Tsugumi; Meehan, Terrence F.; Kempfle, Judith S.; Kenna, Tony J.; Kere, Juha; Khachigian, Levon M.; Kitamura, Toshio; Klinken, Svend Peter; Knox, Alan; Kojima, Miki; Kojima, Soichi; Kondo, Naoto; Schmeier, Sebastian; Koseki, Haruhiko; Koyasu, Shigeo; Krampitz, Sarah; Kubosaki, Atsutaka; Kwon, Andrew T.; Laros, Jeroen F J; Lee, Weonju; Lennartsson, Andreas; Li, Kang; Lilje, Berit; Bertin, Nicolas; Lipovich, Leonard; MacKay-Sim, Alan; Manabe, Riichiroh; Mar, Jessica; Marchand, Benoît; Mathelier, Anthony; Mejhert, Niklas; Meynert, Alison M.; Mizuno, Yosuke; De Morais, David A Lima; Jørgensen, Mette Christine; Morikawa, Hiromasa; Morimoto, Mitsuru; Moro, Kazuyo; Motakis, Efthymios; Motohashi, Hozumi; Mummery, Christine L.; Murata, Mitsuyoshi; Nagao-Sato, Sayaka; Nakachi, Yutaka; Nakahara, Fumio; Dimont, Emmanuel; Nakamura, Toshiyuki; Nakamura, Yukio; Nakazato, Kenichi; Van Nimwegen, Erik; Ninomiya, Noriko; Nishiyori, Hiromi; Noma, Shohei; Nozaki, Tadasuke; Ogishima, Soichi; Ohkura, Naganari; Arner, Erik; Ohmiya, Hiroko; Ohno, Hiroshi; Ohshima, Mitsuhiro; Okada-Hatakeyama, Mariko; Okazaki, Yasushi; Orlando, Valerio; Ovchinnikov, Dmitry A.; Pain, Arnab ( 0000-0002-1755-2819 ) ; Passier, Robert C J J; Patrikakis, Margaret; Schmidl, Christian; Persson, Helena A.; Piazza, Silvano; Prendergast, James G D; Rackham, Owen J L; Ramilowski, Jordan A.; Rashid, Mamoon ( 0000-0003-4851-4994 ) ; Ravasi, Timothy ( 0000-0002-9950-465X ) ; Rizzu, Patrizia; Roncador, Marco; Roy, Sugata; Schaefer, Ulf; Rye, Morten Beck; Saijyo, Eri; Sajantila, Antti; Saka, Akiko; Sakaguchi, Shimon; Sakai, Mizuho; Sato, Hiroki; Satoh, Hironori; Savvi, Suzana; Saxena, Alka; Medvedeva, Yulia; Schneider, Claudio H.; Schultes, Erik A.; Schulze-Tanzil, Gundula G.; Schwegmann, Anita; Sengstag, Thierry; Sheng, Guojun; Shimoji, Hisashi; Shimoni, Yishai; Shin, Jay W.; Simon, Chris M.; Plessy, Charles; Sugiyama, Daisuke; Sugiyama, Takaaki; Suzuki, Masanori; Suzuki, Naoko; Swoboda, Rolf K.; 't Hoen, Peter Ac Chr; Tagami, Michihira; Tagami, Naokotakahashi; Takai, Jun; Tanaka, Hiroshi; Vitezic, Morana; Tatsukawa, Hideki; Tatum, Zuotian; Thompson, Mark; Toyoda, Hiroo; Toyoda, Tetsuro; Valen, Eivind; Van De Wetering, Marc L.; Van Den Berg, Linda M.; Verardo, Roberto; Vijayan, Dipti; Severin, Jessica M.; Vorontsov, Ilya E.; Wasserman, Wyeth W.; Watanabe, Shoko; Wells, Christine A.; Winteringham, Louise Natalie; Wolvetang, Ernst Jurgen; Wood, Emily J.; Yamaguchi, Yoko; Yamamoto, Masayuki; Yoneda, Misako; Semple, Colin Am M; Yonekura, Yohei; Yoshida, Shigehiro; Zabierowski, Susan E.; Zhang, Peter; Zhao, Xiaobei; Zucchelli, Silvia; Summers, Kim M.; Suzuki, Harukazu; Daub, Carsten Olivier; Kawai, Jun; Ishizu, Yuri; Heutink, Peter; Hide, Winston; Freeman, Tom C.; Lenhard, Boris; Bajic, Vladimir B. ( 0000-0001-5435-4750 ) ; Taylor, Martin S.; Makeev, Vsevolod J.; Sandelin, Albin; Hume, David A.; Carninci, Piero; Young, Robert S.; Hayashizaki, Yoshihide Yoshihide; Francescatto, Margherita; Altschuler, Intikhab Alam; Albanese, Davide; Altschule, Gabriel M.; Arakawa, Takahiro; Archer, John A.C. ( 0000-0002-3302-3933 ) ; Arner, Peter; Babina, Magda; Rennie, Sarah; Balwierz, Piotr J.; Beckhouse, Anthony G.; Pradhan-Bhatt, Swati; Blake, Judith A.; Blumenthal, Antje; Bodega, Beatrice; Bonetti, Alessandro; Briggs, James A.; Brombacher, Frank; Burroughs, Alexander Maxwell; Califano, Andrea C.; Cannistraci, Carlo; Carbajo, Daniel; Chen, Yun; Chierici, Marco; Ciani, Yari; Clevers, Hans C.; Dalla, Emiliano; Davis, Carrie Anne; Detmar, Michael J.; Diehl, Alexander D.; Dohi, Taeko; Drabløs, Finn; Edge, Albert SB B; Edinger, Matthias G.; Ekwall, Karl; Endoh, Mitsuhiro; Enomoto, Hideki; Fagiolini, Michela; Fairbairn, Lynsey R.; Fang, Hai; Farach-Carson, Mary Cindy; Faulkner, Geoffrey J.; Favorov, Alexander V.; Fisher, Malcolm E.; Frith, Martin C.; Fujita, Rie; Fukuda, Shiro; Furlanello, Cesare; Furuno, Masaaki; Furusawa, Junichi; Geijtenbeek, Teunis Bh H; Gibson, Andrew P.; Gingeras, Thomas R.; Goldowitz, Dan; Gough, Julian; Guhl, Sven; Guler, Reto; Gustincich, Stefano; Ha, Thomas; Hamaguchi, Masahide; Hara, Mitsuko; Harbers, Matthias; Harshbarger, Jayson; Hasegawa, Akira; Hasegawa, Yuki; Hashimoto, Takehiro; Herlyn, Meenhard F.; Hitchens, Kelly J.; Sui, Shannan J Ho; Hofmann, Oliver M.; Hoof, Ilka; Hori, Fumi; Huminiecki, Łukasz B.
Abstract:
Regulated transcription controls the diversity, developmental pathways and spatial organization of the hundreds of cell types that make up a mammal. Using single-molecule cDNA sequencing, we mapped transcription start sites (TSSs) and their usage in human and mouse primary cells, cell lines and tissues to produce a comprehensive overview of mammalian gene expression across the human body. We find that few genes are truly ‘housekeeping’, whereas many mammalian promoters are composite entities composed of several closely separated TSSs, with independent cell-type-specific expression profiles. TSSs specific to different cell types evolve at different rates, whereas promoters of broadly expressed genes are the most conserved. Promoter-based expression analysis reveals key transcription factors defining cell states and links them to binding-site motifs. The functions of identified novel transcripts can be predicted by coexpression and sample ontology enrichment analyses. The functional annotation of the mammalian genome 5 (FANTOM5) project provides comprehensive expression profiles and functional annotation of mammalian cell-type-specific transcriptomes with wide applications in biomedical research.
KAUST Department:
Computational Bioscience Research Center (CBRC); Biological and Environmental Sciences and Engineering (BESE) Division; Environmental Science and Engineering Program; Applied Mathematics and Computational Science Program
Publisher:
Springer Nature
Journal:
Nature
Issue Date:
26-Mar-2014
DOI:
10.1038/nature13182
Type:
Article
Sponsors:
FANTOM5 was made possible by a Research Grant for RIKEN Omics Science Center from MEXT to Y. Hayashizaki and a grant of the Innovative Cell Biology by Innovative Technology (Cell Innovation Program) from the MEXT, Japan to Y. Hayashizaki. It was also supported by Research Grants for RIKEN Preventive Medicine and Diagnosis Innovation Program(RIKEN PMI) to Y. Hayashizaki and RIKEN Centre for Life Science Technologies, Division of Genomic Technologies (RIKEN CLST (DGT)) from the MEXT, Japan. Extended acknowledgements are provided in the Supplementary Information.
Appears in Collections:
Articles; Environmental Science and Engineering Program; Applied Mathematics and Computational Science Program; Computational Bioscience Research Center (CBRC); Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorForest, Alistair R Ren
dc.contributor.authorKawaji, Hideyaen
dc.contributor.authorRehli, Michaelen
dc.contributor.authorBaillie, John Kennethen
dc.contributor.authorDe Hoon, Michiel Jl Len
dc.contributor.authorHaberle, Vanjaen
dc.contributor.authorLassmann, Timoen
dc.contributor.authorKulakovskiy, Ivan V.en
dc.contributor.authorLizio, Marinaen
dc.contributor.authorItoh, Masayoshien
dc.contributor.authorAndersson, Robinen
dc.contributor.authorIida, Keien
dc.contributor.authorIkawa, Tomokatsuen
dc.contributor.authorJankovic, Boris R.en
dc.contributor.authorJia, Huien
dc.contributor.authorJoshi, Anagha Madhusudanen
dc.contributor.authorJurman, Giuseppeen
dc.contributor.authorKaczkowski, Bogumiłen
dc.contributor.authorKai, Chiekoen
dc.contributor.authorKaida, Kaoruen
dc.contributor.authorKaiho, Aien
dc.contributor.authorMungall, Christopher J.en
dc.contributor.authorKajiyama, Kazuhiroen
dc.contributor.authorKanamori-Katayama, Mutsumien
dc.contributor.authorKasianov, Artem S.en
dc.contributor.authorKasukawa, Takeyaen
dc.contributor.authorKatayama, Shintaroen
dc.contributor.authorKato, Sachien
dc.contributor.authorKawaguchi, Shujien
dc.contributor.authorKawamoto, Hiroshien
dc.contributor.authorKawamura, Yuki I.en
dc.contributor.authorKawashima, Tsugumien
dc.contributor.authorMeehan, Terrence F.en
dc.contributor.authorKempfle, Judith S.en
dc.contributor.authorKenna, Tony J.en
dc.contributor.authorKere, Juhaen
dc.contributor.authorKhachigian, Levon M.en
dc.contributor.authorKitamura, Toshioen
dc.contributor.authorKlinken, Svend Peteren
dc.contributor.authorKnox, Alanen
dc.contributor.authorKojima, Mikien
dc.contributor.authorKojima, Soichien
dc.contributor.authorKondo, Naotoen
dc.contributor.authorSchmeier, Sebastianen
dc.contributor.authorKoseki, Haruhikoen
dc.contributor.authorKoyasu, Shigeoen
dc.contributor.authorKrampitz, Sarahen
dc.contributor.authorKubosaki, Atsutakaen
dc.contributor.authorKwon, Andrew T.en
dc.contributor.authorLaros, Jeroen F Jen
dc.contributor.authorLee, Weonjuen
dc.contributor.authorLennartsson, Andreasen
dc.contributor.authorLi, Kangen
dc.contributor.authorLilje, Beriten
dc.contributor.authorBertin, Nicolasen
dc.contributor.authorLipovich, Leonarden
dc.contributor.authorMacKay-Sim, Alanen
dc.contributor.authorManabe, Riichirohen
dc.contributor.authorMar, Jessicaen
dc.contributor.authorMarchand, Benoîten
dc.contributor.authorMathelier, Anthonyen
dc.contributor.authorMejhert, Niklasen
dc.contributor.authorMeynert, Alison M.en
dc.contributor.authorMizuno, Yosukeen
dc.contributor.authorDe Morais, David A Limaen
dc.contributor.authorJørgensen, Mette Christineen
dc.contributor.authorMorikawa, Hiromasaen
dc.contributor.authorMorimoto, Mitsuruen
dc.contributor.authorMoro, Kazuyoen
dc.contributor.authorMotakis, Efthymiosen
dc.contributor.authorMotohashi, Hozumien
dc.contributor.authorMummery, Christine L.en
dc.contributor.authorMurata, Mitsuyoshien
dc.contributor.authorNagao-Sato, Sayakaen
dc.contributor.authorNakachi, Yutakaen
dc.contributor.authorNakahara, Fumioen
dc.contributor.authorDimont, Emmanuelen
dc.contributor.authorNakamura, Toshiyukien
dc.contributor.authorNakamura, Yukioen
dc.contributor.authorNakazato, Kenichien
dc.contributor.authorVan Nimwegen, Eriken
dc.contributor.authorNinomiya, Norikoen
dc.contributor.authorNishiyori, Hiromien
dc.contributor.authorNoma, Shoheien
dc.contributor.authorNozaki, Tadasukeen
dc.contributor.authorOgishima, Soichien
dc.contributor.authorOhkura, Naganarien
dc.contributor.authorArner, Eriken
dc.contributor.authorOhmiya, Hirokoen
dc.contributor.authorOhno, Hiroshien
dc.contributor.authorOhshima, Mitsuhiroen
dc.contributor.authorOkada-Hatakeyama, Marikoen
dc.contributor.authorOkazaki, Yasushien
dc.contributor.authorOrlando, Valerioen
dc.contributor.authorOvchinnikov, Dmitry A.en
dc.contributor.authorPain, Arnaben
dc.contributor.authorPassier, Robert C J Jen
dc.contributor.authorPatrikakis, Margareten
dc.contributor.authorSchmidl, Christianen
dc.contributor.authorPersson, Helena A.en
dc.contributor.authorPiazza, Silvanoen
dc.contributor.authorPrendergast, James G Den
dc.contributor.authorRackham, Owen J Len
dc.contributor.authorRamilowski, Jordan A.en
dc.contributor.authorRashid, Mamoonen
dc.contributor.authorRavasi, Timothyen
dc.contributor.authorRizzu, Patriziaen
dc.contributor.authorRoncador, Marcoen
dc.contributor.authorRoy, Sugataen
dc.contributor.authorSchaefer, Ulfen
dc.contributor.authorRye, Morten Becken
dc.contributor.authorSaijyo, Erien
dc.contributor.authorSajantila, Anttien
dc.contributor.authorSaka, Akikoen
dc.contributor.authorSakaguchi, Shimonen
dc.contributor.authorSakai, Mizuhoen
dc.contributor.authorSato, Hirokien
dc.contributor.authorSatoh, Hironorien
dc.contributor.authorSavvi, Suzanaen
dc.contributor.authorSaxena, Alkaen
dc.contributor.authorMedvedeva, Yuliaen
dc.contributor.authorSchneider, Claudio H.en
dc.contributor.authorSchultes, Erik A.en
dc.contributor.authorSchulze-Tanzil, Gundula G.en
dc.contributor.authorSchwegmann, Anitaen
dc.contributor.authorSengstag, Thierryen
dc.contributor.authorSheng, Guojunen
dc.contributor.authorShimoji, Hisashien
dc.contributor.authorShimoni, Yishaien
dc.contributor.authorShin, Jay W.en
dc.contributor.authorSimon, Chris M.en
dc.contributor.authorPlessy, Charlesen
dc.contributor.authorSugiyama, Daisukeen
dc.contributor.authorSugiyama, Takaakien
dc.contributor.authorSuzuki, Masanorien
dc.contributor.authorSuzuki, Naokoen
dc.contributor.authorSwoboda, Rolf K.en
dc.contributor.author't Hoen, Peter Ac Chren
dc.contributor.authorTagami, Michihiraen
dc.contributor.authorTagami, Naokotakahashien
dc.contributor.authorTakai, Junen
dc.contributor.authorTanaka, Hiroshien
dc.contributor.authorVitezic, Moranaen
dc.contributor.authorTatsukawa, Hidekien
dc.contributor.authorTatum, Zuotianen
dc.contributor.authorThompson, Marken
dc.contributor.authorToyoda, Hirooen
dc.contributor.authorToyoda, Tetsuroen
dc.contributor.authorValen, Eivinden
dc.contributor.authorVan De Wetering, Marc L.en
dc.contributor.authorVan Den Berg, Linda M.en
dc.contributor.authorVerardo, Robertoen
dc.contributor.authorVijayan, Diptien
dc.contributor.authorSeverin, Jessica M.en
dc.contributor.authorVorontsov, Ilya E.en
dc.contributor.authorWasserman, Wyeth W.en
dc.contributor.authorWatanabe, Shokoen
dc.contributor.authorWells, Christine A.en
dc.contributor.authorWinteringham, Louise Natalieen
dc.contributor.authorWolvetang, Ernst Jurgenen
dc.contributor.authorWood, Emily J.en
dc.contributor.authorYamaguchi, Yokoen
dc.contributor.authorYamamoto, Masayukien
dc.contributor.authorYoneda, Misakoen
dc.contributor.authorSemple, Colin Am Men
dc.contributor.authorYonekura, Yoheien
dc.contributor.authorYoshida, Shigehiroen
dc.contributor.authorZabierowski, Susan E.en
dc.contributor.authorZhang, Peteren
dc.contributor.authorZhao, Xiaobeien
dc.contributor.authorZucchelli, Silviaen
dc.contributor.authorSummers, Kim M.en
dc.contributor.authorSuzuki, Harukazuen
dc.contributor.authorDaub, Carsten Olivieren
dc.contributor.authorKawai, Junen
dc.contributor.authorIshizu, Yurien
dc.contributor.authorHeutink, Peteren
dc.contributor.authorHide, Winstonen
dc.contributor.authorFreeman, Tom C.en
dc.contributor.authorLenhard, Borisen
dc.contributor.authorBajic, Vladimir B.en
dc.contributor.authorTaylor, Martin S.en
dc.contributor.authorMakeev, Vsevolod J.en
dc.contributor.authorSandelin, Albinen
dc.contributor.authorHume, David A.en
dc.contributor.authorCarninci, Pieroen
dc.contributor.authorYoung, Robert S.en
dc.contributor.authorHayashizaki, Yoshihide Yoshihideen
dc.contributor.authorFrancescatto, Margheritaen
dc.contributor.authorAltschuler, Intikhab Alamen
dc.contributor.authorAlbanese, Davideen
dc.contributor.authorAltschule, Gabriel M.en
dc.contributor.authorArakawa, Takahiroen
dc.contributor.authorArcher, John A.C.en
dc.contributor.authorArner, Peteren
dc.contributor.authorBabina, Magdaen
dc.contributor.authorRennie, Sarahen
dc.contributor.authorBalwierz, Piotr J.en
dc.contributor.authorBeckhouse, Anthony G.en
dc.contributor.authorPradhan-Bhatt, Swatien
dc.contributor.authorBlake, Judith A.en
dc.contributor.authorBlumenthal, Antjeen
dc.contributor.authorBodega, Beatriceen
dc.contributor.authorBonetti, Alessandroen
dc.contributor.authorBriggs, James A.en
dc.contributor.authorBrombacher, Franken
dc.contributor.authorBurroughs, Alexander Maxwellen
dc.contributor.authorCalifano, Andrea C.en
dc.contributor.authorCannistraci, Carloen
dc.contributor.authorCarbajo, Danielen
dc.contributor.authorChen, Yunen
dc.contributor.authorChierici, Marcoen
dc.contributor.authorCiani, Yarien
dc.contributor.authorClevers, Hans C.en
dc.contributor.authorDalla, Emilianoen
dc.contributor.authorDavis, Carrie Anneen
dc.contributor.authorDetmar, Michael J.en
dc.contributor.authorDiehl, Alexander D.en
dc.contributor.authorDohi, Taekoen
dc.contributor.authorDrabløs, Finnen
dc.contributor.authorEdge, Albert SB Ben
dc.contributor.authorEdinger, Matthias G.en
dc.contributor.authorEkwall, Karlen
dc.contributor.authorEndoh, Mitsuhiroen
dc.contributor.authorEnomoto, Hidekien
dc.contributor.authorFagiolini, Michelaen
dc.contributor.authorFairbairn, Lynsey R.en
dc.contributor.authorFang, Haien
dc.contributor.authorFarach-Carson, Mary Cindyen
dc.contributor.authorFaulkner, Geoffrey J.en
dc.contributor.authorFavorov, Alexander V.en
dc.contributor.authorFisher, Malcolm E.en
dc.contributor.authorFrith, Martin C.en
dc.contributor.authorFujita, Rieen
dc.contributor.authorFukuda, Shiroen
dc.contributor.authorFurlanello, Cesareen
dc.contributor.authorFuruno, Masaakien
dc.contributor.authorFurusawa, Junichien
dc.contributor.authorGeijtenbeek, Teunis Bh Hen
dc.contributor.authorGibson, Andrew P.en
dc.contributor.authorGingeras, Thomas R.en
dc.contributor.authorGoldowitz, Danen
dc.contributor.authorGough, Julianen
dc.contributor.authorGuhl, Svenen
dc.contributor.authorGuler, Retoen
dc.contributor.authorGustincich, Stefanoen
dc.contributor.authorHa, Thomasen
dc.contributor.authorHamaguchi, Masahideen
dc.contributor.authorHara, Mitsukoen
dc.contributor.authorHarbers, Matthiasen
dc.contributor.authorHarshbarger, Jaysonen
dc.contributor.authorHasegawa, Akiraen
dc.contributor.authorHasegawa, Yukien
dc.contributor.authorHashimoto, Takehiroen
dc.contributor.authorHerlyn, Meenhard F.en
dc.contributor.authorHitchens, Kelly J.en
dc.contributor.authorSui, Shannan J Hoen
dc.contributor.authorHofmann, Oliver M.en
dc.contributor.authorHoof, Ilkaen
dc.contributor.authorHori, Fumien
dc.contributor.authorHuminiecki, Łukasz B.en
dc.date.accessioned2015-08-12T08:55:57Zen
dc.date.available2015-08-12T08:55:57Zen
dc.date.issued2014-03-26en
dc.identifier.doi10.1038/nature13182en
dc.identifier.urihttp://hdl.handle.net/10754/565944en
dc.description.abstractRegulated transcription controls the diversity, developmental pathways and spatial organization of the hundreds of cell types that make up a mammal. Using single-molecule cDNA sequencing, we mapped transcription start sites (TSSs) and their usage in human and mouse primary cells, cell lines and tissues to produce a comprehensive overview of mammalian gene expression across the human body. We find that few genes are truly ‘housekeeping’, whereas many mammalian promoters are composite entities composed of several closely separated TSSs, with independent cell-type-specific expression profiles. TSSs specific to different cell types evolve at different rates, whereas promoters of broadly expressed genes are the most conserved. Promoter-based expression analysis reveals key transcription factors defining cell states and links them to binding-site motifs. The functions of identified novel transcripts can be predicted by coexpression and sample ontology enrichment analyses. The functional annotation of the mammalian genome 5 (FANTOM5) project provides comprehensive expression profiles and functional annotation of mammalian cell-type-specific transcriptomes with wide applications in biomedical research.en
dc.description.sponsorshipFANTOM5 was made possible by a Research Grant for RIKEN Omics Science Center from MEXT to Y. Hayashizaki and a grant of the Innovative Cell Biology by Innovative Technology (Cell Innovation Program) from the MEXT, Japan to Y. Hayashizaki. It was also supported by Research Grants for RIKEN Preventive Medicine and Diagnosis Innovation Program(RIKEN PMI) to Y. Hayashizaki and RIKEN Centre for Life Science Technologies, Division of Genomic Technologies (RIKEN CLST (DGT)) from the MEXT, Japan. Extended acknowledgements are provided in the Supplementary Information.en
dc.publisherSpringer Natureen
dc.subjectAlen
dc.titleA promoter-level mammalian expression atlasen
dc.typeArticleen
dc.contributor.departmentComputational Bioscience Research Center (CBRC)en
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.contributor.departmentEnvironmental Science and Engineering Programen
dc.contributor.departmentApplied Mathematics and Computational Science Programen
dc.identifier.journalNatureen
dc.contributor.institutionRIKEN, OSC, Tsurumi Ku, Yokohama, Kanagawa 2300045, Japanen
dc.contributor.institutionRIKEN, CLST, DGT, Tsurumi Ku, Yokohama, Kanagawa 2300045, Japanen
dc.contributor.institutionRIKEN, Prevent Med & Diag Innovat Program PMI, Wako, Saitama 3510198, Japanen
dc.contributor.institutionUniv Hosp Regensburg, Dept Internal Med 3, D-93042 Regensburg, Germanyen
dc.contributor.institutionRegensburg Ctr Intervent Immunol RCI, D-93042 Regensburg, Germanyen
dc.contributor.institutionUniv Edinburgh, Roslin Inst, Edinburgh EH25 9RG, Midlothian, Scotlanden
dc.contributor.institutionUniv Edinburgh, Royal Dick Sch Vet Studies, Edinburgh EH25 9RG, Midlothian, Scotlanden
dc.contributor.institutionUniv Bergen, Dept Biol, NO-5006 Bergen, Norwayen
dc.contributor.institutionUniv London Imperial Coll Sci Technol & Med, Fac Med, Inst Clin Sci, MRC Clin Sci Ctr, London W12 0NN, Englanden
dc.contributor.institutionRussian Acad Sci, VA Engelhardt Mol Biol Inst, Moscow 119991, Russiaen
dc.contributor.institutionRussian Acad Sci, Vavilov Inst Gen Genet, Moscow 119991, Russiaen
dc.contributor.institutionUniv Copenhagen, Bioinformat Ctr, Dept Biol, DK-2200 Copenhagen, Denmarken
dc.contributor.institutionUniv Copenhagen, BRIC, DK-2200 Copenhagen, Denmarken
dc.contributor.institutionUniv Calif Berkeley, Lawrence Berkeley Natl Lab, Genom Div, Berkeley, CA 94720 USAen
dc.contributor.institutionEuropean Bioinformat Inst, European Mol Biol Lab, Cambridge CB10 1SD, Englanden
dc.contributor.institutionMassey Univ, North Shore Mail Ctr, Inst Nat & Math Sci, Auckland 0745, New Zealanden
dc.contributor.institutionHarvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USAen
dc.contributor.institutionKarolinska Inst, Dept Cell & Mol Biol, SE-17177 Stockholm, Swedenen
dc.contributor.institutionUniv Edinburgh, Western Gen Hosp, MRC Human Genet Unit, MRC IGMM, Edinburgh EH4 2XU, Midlothian, Scotlanden
dc.contributor.institutionVrije Univ Amsterdam, Dept Clin Genet, Med Ctr Amsterdam, NL-1081 BT Amsterdam, Netherlandsen
dc.contributor.institutionUniv Porto, Grad Program Areas Basic & Appl Biol, Abel Salazar Biomed Sci Inst, P-4050313 Oporto, Portugalen
dc.contributor.institutionFdn Bruno Kessler, I-38123 Trento, Italyen
dc.contributor.institutionKarolinska Inst, Dept Med, Karolinska Univ Hosp, SE-14186 Huddinge, Swedenen
dc.contributor.institutionUniv Med Berlin, Dept Dermatol & Allergy, D-10117 Berlin, Germanyen
dc.contributor.institutionUniv Basel, Biozentrum, CH-4056 Basel, Switzerlanden
dc.contributor.institutionUniv Queensland, AIBN, St Lucia, Qld 4072, Australiaen
dc.contributor.institutionUniv Queensland, Australian Infect Dis Res Ctr AID, St Lucia, Qld 4072, Australiaen
dc.contributor.institutionUniv Delaware, Dept Biol Sci, Newark, DE 19713 USAen
dc.contributor.institutionJackson Lab, Bar Harbor, ME 04609 USAen
dc.contributor.institutionUniv Queensland, Diamantina Inst, St Lucia, Qld 4072, Australiaen
dc.contributor.institutionIRCCS Fdn Santa Lucia, I-00143 Rome, Italyen
dc.contributor.institutionInt Ctr Genet Engn & Biotechnol ICGEB Cape Town C, ZA-7925 Cape Town, South Africaen
dc.contributor.institutionUniv Cape Town, Div Immunol, Inst Infect Dis & Mol Med IDM, ZA-7925 Cape Town, South Africaen
dc.contributor.institutionColumbia Univ, Med Ctr, Dept Syst Biol, New York, NY 10032 USAen
dc.contributor.institutionColumbia Univ, Med Ctr, Dept Biochem & Mol Biophys, New York, NY 10032 USAen
dc.contributor.institutionColumbia Univ, Med Ctr, Dept Biomed Informat, New York, NY 10032 USAen
dc.contributor.institutionColumbia Univ, Med Ctr, Herbert Irving Comprehens Canc Ctr, Inst Canc Genet, New York, NY 10032 USAen
dc.contributor.institutionAlbert Einstein Coll Med, Dept Syst & Computat Biol, Bronx, NY 10461 USAen
dc.contributor.institutionLNCIB, I-34149 Trieste, Italyen
dc.contributor.institutionHubrecht Inst, NL-3584 CT Utrecht, Netherlandsen
dc.contributor.institutionRoyal Netherlands Acad Arts & Sci, NL-1000 GC Amsterdam, Netherlandsen
dc.contributor.institutionUniv Med Ctr Utrecht, NL-3508 GA Utrecht, Netherlandsen
dc.contributor.institutionCold Spring Harbor Lab, Cold Spring Harbor, NY 11797 USAen
dc.contributor.institutionETH, Inst Pharmaceut Sci, CH-8093 Zurich, Switzerlanden
dc.contributor.institutionSUNY Buffalo, Dept Neurol, Sch Med & Biomed Sci, New York State Ctr Excellence Bioinformat & Life, Buffalo, NY 14203 USAen
dc.contributor.institutionNatl Ctr Global Hlth & Med, Res Ctr Hepatitis & Immunol Res Inst, Ichikawa, Chiba 2728516, Japanen
dc.contributor.institutionNorwegian Univ Sci & Technol NTNU, Dept Canc Res & Mol Med, NO-7491 Trondheim, Norwayen
dc.contributor.institutionHarvard Univ, Sch Med, Massachusetts Eye & Ear Infirm, Dept Otol & Laryngol, Boston, MA 02114 USAen
dc.contributor.institutionKarolinska Inst, Dept Biosci & Nutr, Ctr Biosci, SE-14183 Huddinge, Swedenen
dc.contributor.institutionRIKEN, RCAI, Tsurumi Ku, Yokohama, Kanagawa 2300045, Japanen
dc.contributor.institutionRIKEN, Ctr Integrat Med Sci, Tsurumi Ku, Yokohama, Kanagawa 2300045, Japanen
dc.contributor.institutionRIKEN, CDB, Chuo Ku, Kobe, Hyogo 6500047, Japanen
dc.contributor.institutionHarvard Univ, Sch Med, FM Kirby Neurobiol Ctr, Childrens Hosp Boston, Boston, MA 02115 USAen
dc.contributor.institutionUniv Bristol, Dept Comp Sci, Bristol BS8 1UB, Avon, Englanden
dc.contributor.institutionRice Univ, Dept Biochem & Cell Biol, Houston, TX 77251 USAen
dc.contributor.institutionMater Med Res Inst, Cancer Biol Program, South Brisbane, Qld 4101, Australiaen
dc.contributor.institutionJohns Hopkins Univ, Sch Med, Dept Oncol, Div Oncol Biostat & Bioinformat, Baltimore, MD 21205 USAen
dc.contributor.institutionState Res Inst Genet & Select Ind Microorganisms, Moscow 117545, Russiaen
dc.contributor.institutionNatl Inst Adv Ind Sci & Technol, Computat Biol Res Ctr, Koto Ku, Tokyo 1350064, Japanen
dc.contributor.institutionTohoku Univ, Dept Med Biochem, Grad Sch Med, Aoba Ku, Sendai, Miyagi 9808575, Japanen
dc.contributor.institutionKeio Univ, Sch Med, Dept Microbiol & Immunol, Shinjuku Ku, Tokyo 1608582, Japanen
dc.contributor.institutionUniv Amsterdam, Acad Med Ctr, NL-1105 AZ Amsterdam, Netherlandsen
dc.contributor.institutionLeiden Univ, Med Ctr, Dept Human Genet, NL-2333 ZC Leiden, Netherlandsen
dc.contributor.institutionUniv British Columbia, Dept Med Genet, Ctr Mol Med & Therapeut, Child & Family Res Inst, Vancouver, BC V5Z 4H4, Canadaen
dc.contributor.institutionSISSA, I-34136 Trieste, Italyen
dc.contributor.institutionOsaka Univ, Immunol Frontier Res Ctr, Suita, Osaka 5650871, Japanen
dc.contributor.institutionRIKEN, ASI, Wako, Saitama 3510198, Japanen
dc.contributor.institutionWistar Inst Anat & Biol, Melanoma Res Ctr, Philadelphia, PA 19104 USAen
dc.contributor.institutionRIKEN, Bioinformat & Syst Engn Div BASE, Yokohama, Kanagawa 2300045, Japanen
dc.contributor.institutionWayne State Univ, Ctr Mol Med & Genet, Detroit, MI 48201 USAen
dc.contributor.institutionUniv Tokyo, Lab Anim Res Ctr, Inst Med Sci, Minato Ku, Tokyo 1088639, Japanen
dc.contributor.institutionSci Life Lab, SE-17121 Solna, Swedenen
dc.contributor.institutionUniv New S Wales, Ctr Vasc Res, Sydney, NSW 2052, Australiaen
dc.contributor.institutionUniv Tokyo, Div Cellular Therapy, Inst Med Sci, Tokyo 1088639, Japanen
dc.contributor.institutionUniv Tokyo, Div Stem Cell Signaling, Inst Med Sci, Tokyo 1088639, Japanen
dc.contributor.institutionUniv Western Australia, Harry Perkins Inst Med Res, QEII Med Ctr, Perth, WA 6009, Australiaen
dc.contributor.institutionUniv Western Australia, Med Res Ctr, QEII Med Ctr, Perth, WA 6009, Australiaen
dc.contributor.institutionUniv Nottingham, City Hosp, Nottingham NG5 1PB, Englanden
dc.contributor.institutionKyungpook Natl Univ, Sch Med, Dept Dermatol, Taegu 700721, South Koreaen
dc.contributor.institutionGriffith Univ, Natl Ctr Adult Stem Cell Res, Eskitis Inst Cell & Mol Therapies, Brisbane, Qld 4111, Australiaen
dc.contributor.institutionSaitama Med Univ, Div Funct Genom & Syst Med, Res Ctr Genom Med, Hidaka, Saitama 3501241, Japanen
dc.contributor.institutionUniv Bristol, Fac Engn, Clifton BS81UB, Englanden
dc.contributor.institutionJapanese Sci & Technol Agcy JST, PRESTO, Tokyo 1020076, Japanen
dc.contributor.institutionTohoku Univ, Ctr Radioisotope Sci, Grad Sch Med, Aoba Ku, Sendai, Miyagi 9808575, Japanen
dc.contributor.institutionLeiden Univ, Med Ctr, NL-2300 RC Leiden, Netherlandsen
dc.contributor.institutionSaitama Med Univ, Div Translat Res, Res Ctr Genom Med, Hidaka, Saitama 3501241, Japanen
dc.contributor.institutionRIKEN, BioResource Ctr BRC, Tsukuba, Ibaraki 3050074, Japanen
dc.contributor.institutionTokyo Univ Pharm & Life Sci, Dept Clin Mol Genet, Sch Pharm, Hachioji, Tokyo 1920392, Japanen
dc.contributor.institutionTokyo Med & Dent Univ, Dept Bioinformat, Med Res Inst, Bunkyo Ku, Tokyo 1138510, Japanen
dc.contributor.institutionOhu Univ, Dept Biochem, Sch Pharmaceut Sci, Koriyama, Fukushima 9638611, Japanen
dc.contributor.institutionUniv Helsinki, Dept Forens Med, Hjelt Inst, Helsinki 003000, Finlanden
dc.contributor.institutionUniv Udine, DSMB, I-33100 Udine, Italyen
dc.contributor.institutionCharite, Dept Orthoped Trauma & Reconstruct Surg, D-14195 Berlin, Germanyen
dc.contributor.institutionKyushu Univ Hosp, Ctr Clin & Translat Reseach, Higashi Ku, Fukuoka 8128582, Japanen
dc.contributor.institutionNagoya Univ, Grad Sch Pharmaceut Sci, Chikusa Ku, Nagoya, Aichi 4648601, Japanen
dc.contributor.institutionHarvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USAen
dc.contributor.institutionNihon Univ, Dept Biochem, Sch Dent, Chiyoda Ku, Tokyo 1018310, Japanen
dc.contributor.institutionUniv Bergen, Dept Informat, NO-5008 Bergen, Norwayen
dc.contributor.institutionMIPT, Dept Biol & Med Phys, Dolgoprudnyi 141700, Moscow Region, Russiaen
kaust.authorSchmeier, Sebastianen
kaust.authorMedvedeva, Yuliaen
kaust.authorArcher, Johnen
kaust.authorCannistraci, Carloen
kaust.authorOrlando, Valerioen
kaust.authorPain, Arnaben
kaust.authorRashid, Mamoonen
kaust.authorRavasi, Timothyen
kaust.authorBajic, Vladimir B.en
kaust.authorSchaefer, Ulfen
kaust.authorAltschuler, Intikhab Alamen
kaust.authorJankovic, Boris R.en
kaust.authorMarchand, Benoîten
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