Targeted cancer cell death induced by biofunctionalized magnetic nanowires

Handle URI:
http://hdl.handle.net/10754/564882
Title:
Targeted cancer cell death induced by biofunctionalized magnetic nanowires
Authors:
Contreras, Maria F. ( 0000-0001-6239-5325 ) ; Ravasi, Timothy ( 0000-0002-9950-465X ) ; Kosel, Jürgen ( 0000-0002-8998-8275 )
Abstract:
Magnetic micro and nanomaterials are increasingly interesting for biomedical applications since they possess many advantageous properties: they can become biocompatible, they can be functionalized to target specific cells and they can be remotely manipulated by magnetic fields. The goal of this study is to use antibody-functionalized nickel nanowires (Ab-NWs) as an alternative method in cancer therapy overcoming the limitations of current treatments that lack specificity and are highly cytotoxic. Ab-NWs have been incubated with cancer cells and a 12% drop on cell viability was observed for a treatment of only 10 minutes and an alternating magnetic field of low intensity and low frequency. It is believed that the Ab-NWs vibrate transmitting a mechanical force to the targeted cells inducing cell death. © 2014 IEEE.
KAUST Department:
Bioscience Program; Electrical Engineering Program; Biological and Environmental Sciences and Engineering (BESE) Division; Computational Bioscience Research Center (CBRC); Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division; Integrative Systems Biology Lab; Sensing, Magnetism and Microsystems Lab
Publisher:
Institute of Electrical and Electronics Engineers (IEEE)
Journal:
2nd Middle East Conference on Biomedical Engineering
Conference/Event name:
2014 2nd Middle East Conference on Biomedical Engineering, MECBME 2014
Issue Date:
Feb-2014
DOI:
10.1109/MECBME.2014.6783203
Type:
Conference Paper
ISSN:
21654247
ISBN:
9781479947997
Appears in Collections:
Conference Papers; Bioscience Program; Electrical Engineering Program; Sensing, Magnetism and Microsystems Lab; Computational Bioscience Research Center (CBRC); Biological and Environmental Sciences and Engineering (BESE) Division; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorContreras, Maria F.en
dc.contributor.authorRavasi, Timothyen
dc.contributor.authorKosel, Jürgenen
dc.date.accessioned2015-08-04T07:24:01Zen
dc.date.available2015-08-04T07:24:01Zen
dc.date.issued2014-02en
dc.identifier.isbn9781479947997en
dc.identifier.issn21654247en
dc.identifier.doi10.1109/MECBME.2014.6783203en
dc.identifier.urihttp://hdl.handle.net/10754/564882en
dc.description.abstractMagnetic micro and nanomaterials are increasingly interesting for biomedical applications since they possess many advantageous properties: they can become biocompatible, they can be functionalized to target specific cells and they can be remotely manipulated by magnetic fields. The goal of this study is to use antibody-functionalized nickel nanowires (Ab-NWs) as an alternative method in cancer therapy overcoming the limitations of current treatments that lack specificity and are highly cytotoxic. Ab-NWs have been incubated with cancer cells and a 12% drop on cell viability was observed for a treatment of only 10 minutes and an alternating magnetic field of low intensity and low frequency. It is believed that the Ab-NWs vibrate transmitting a mechanical force to the targeted cells inducing cell death. © 2014 IEEE.en
dc.publisherInstitute of Electrical and Electronics Engineers (IEEE)en
dc.titleTargeted cancer cell death induced by biofunctionalized magnetic nanowiresen
dc.typeConference Paperen
dc.contributor.departmentBioscience Programen
dc.contributor.departmentElectrical Engineering Programen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.contributor.departmentComputational Bioscience Research Center (CBRC)en
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Divisionen
dc.contributor.departmentIntegrative Systems Biology Laben
dc.contributor.departmentSensing, Magnetism and Microsystems Laben
dc.identifier.journal2nd Middle East Conference on Biomedical Engineeringen
dc.conference.date17 February 2014 through 20 February 2014en
dc.conference.name2014 2nd Middle East Conference on Biomedical Engineering, MECBME 2014en
dc.conference.locationDohaen
kaust.authorRavasi, Timothyen
kaust.authorKosel, Jürgenen
kaust.authorContreras, Maria F.en
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