Analysis of different coating thickness on new type of planar interdigital sensors for endotoxin detection

Handle URI:
http://hdl.handle.net/10754/564714
Title:
Analysis of different coating thickness on new type of planar interdigital sensors for endotoxin detection
Authors:
Syaifudin, A. R Mohd; Yu, Paklam; Mukhopadhyay, Subhas Chandra; Gooneratne, Chinthaka Pasan; Kosel, Jürgen ( 0000-0002-8998-8275 )
Abstract:
New types of planar interdigital sensors have been fabricated on Silicon/Silicon Dioxide (Si/SiO2) wafers. The sensors were coated with pre-cursor silica functionalized with APTES (3-aminopropyltrietoxysilane) at different thicknesses. All sensors were then immobilized with Polymyxin, B (PmB). PmB is an antimicrobial peptide produced by the Gram-positive bacterium-Bacillus, has been immobilized on the coated sensors because of its specific binding properties to endotoxin. Studies were conducted to analyze the effect of different thicknesses of coatings on the sensitivity and selectivity of the sensors. It was observed sensors coated with 3 layers of coating has better sensitivity and selectivity to the target molecules (endotoxin) compared to sensors with 5 layers of coating. The repeatability and stability of the coated sensors were tested by multiple standard endotoxin measurement and it was observed that the sensors give a good reproducibility and stability up to six continuous measurements before the coating degrades. © 2013 IEEE.
KAUST Department:
Sensing, Magnetism and Microsystems Lab; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division; Electrical Engineering Program
Publisher:
Institute of Electrical & Electronics Engineers (IEEE)
Journal:
2013 IEEE International Instrumentation and Measurement Technology Conference (I2MTC)
Conference/Event name:
2013 IEEE International Instrumentation and Measurement Technology Conference: Instrumentation and Measurement for Life, I2MTC 2013
Issue Date:
May-2013
DOI:
10.1109/I2MTC.2013.6555663
Type:
Conference Paper
ISSN:
10915281
ISBN:
9781467346221
Appears in Collections:
Conference Papers; Electrical Engineering Program; Sensing, Magnetism and Microsystems Lab; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorSyaifudin, A. R Mohden
dc.contributor.authorYu, Paklamen
dc.contributor.authorMukhopadhyay, Subhas Chandraen
dc.contributor.authorGooneratne, Chinthaka Pasanen
dc.contributor.authorKosel, Jürgenen
dc.date.accessioned2015-08-04T07:13:25Zen
dc.date.available2015-08-04T07:13:25Zen
dc.date.issued2013-05en
dc.identifier.isbn9781467346221en
dc.identifier.issn10915281en
dc.identifier.doi10.1109/I2MTC.2013.6555663en
dc.identifier.urihttp://hdl.handle.net/10754/564714en
dc.description.abstractNew types of planar interdigital sensors have been fabricated on Silicon/Silicon Dioxide (Si/SiO2) wafers. The sensors were coated with pre-cursor silica functionalized with APTES (3-aminopropyltrietoxysilane) at different thicknesses. All sensors were then immobilized with Polymyxin, B (PmB). PmB is an antimicrobial peptide produced by the Gram-positive bacterium-Bacillus, has been immobilized on the coated sensors because of its specific binding properties to endotoxin. Studies were conducted to analyze the effect of different thicknesses of coatings on the sensitivity and selectivity of the sensors. It was observed sensors coated with 3 layers of coating has better sensitivity and selectivity to the target molecules (endotoxin) compared to sensors with 5 layers of coating. The repeatability and stability of the coated sensors were tested by multiple standard endotoxin measurement and it was observed that the sensors give a good reproducibility and stability up to six continuous measurements before the coating degrades. © 2013 IEEE.en
dc.publisherInstitute of Electrical & Electronics Engineers (IEEE)en
dc.subjectAPTESen
dc.subjectendotoxinen
dc.subjectinterdigitalen
dc.subjectpolymyxin Ben
dc.subjectsilicon dioxideen
dc.titleAnalysis of different coating thickness on new type of planar interdigital sensors for endotoxin detectionen
dc.typeConference Paperen
dc.contributor.departmentSensing, Magnetism and Microsystems Laben
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Divisionen
dc.contributor.departmentElectrical Engineering Programen
dc.identifier.journal2013 IEEE International Instrumentation and Measurement Technology Conference (I2MTC)en
dc.conference.date6 May 2013 through 9 May 2013en
dc.conference.name2013 IEEE International Instrumentation and Measurement Technology Conference: Instrumentation and Measurement for Life, I2MTC 2013en
dc.conference.locationMinneapolis, MNen
dc.contributor.institutionSchool of Engineering and Advanced Technology, Massey University, Palmerston North, New Zealanden
kaust.authorGooneratne, Chinthaka Pasanen
kaust.authorKosel, Jürgenen
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