HINT-KB: The human interactome knowledge base

Handle URI:
http://hdl.handle.net/10754/564504
Title:
HINT-KB: The human interactome knowledge base
Authors:
Theofilatos, Konstantinos A.; Dimitrakopoulos, Christos M.; Kleftogiannis, Dimitrios A. ( 0000-0003-1086-821X ) ; Moschopoulos, Charalampos N.; Papadimitriou, Stergios; Likothanassis, Spiridon D.; Mavroudi, Seferina P.
Abstract:
Proteins and their interactions are considered to play a significant role in many cellular processes. The identification of Protein-Protein interactions (PPIs) in human is an open research area. Many Databases, which contain information about experimentally and computationally detected human PPIs as well as their corresponding annotation data, have been developed. However, these databases contain many false positive interactions, are partial and only a few of them incorporate data from various sources. To overcome these limitations, we have developed HINT-KB (http://150.140.142.24:84/Default.aspx) which is a knowledge base that integrates data from various sources, provides a user-friendly interface for their retrieval, estimates a set of features of interest and computes a confidence score for every candidate protein interaction using a modern computational hybrid methodology. © 2012 IFIP International Federation for Information Processing.
KAUST Department:
Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division; Computer Science Program
Publisher:
Springer Science + Business Media
Journal:
IFIP Advances in Information and Communication Technology
Conference/Event name:
8th International Workshop on Artificial Intelligence Applications and Innovations, AIAI 2012: AIAB, AIeIA, CISE, COPA, IIVC, ISQL, MHDW, and WADTMB
Issue Date:
2012
DOI:
10.1007/978-3-642-33412-2_63
Type:
Conference Paper
ISSN:
18684238
ISBN:
9783642334115
Appears in Collections:
Conference Papers; Computer Science Program; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorTheofilatos, Konstantinos A.en
dc.contributor.authorDimitrakopoulos, Christos M.en
dc.contributor.authorKleftogiannis, Dimitrios A.en
dc.contributor.authorMoschopoulos, Charalampos N.en
dc.contributor.authorPapadimitriou, Stergiosen
dc.contributor.authorLikothanassis, Spiridon D.en
dc.contributor.authorMavroudi, Seferina P.en
dc.date.accessioned2015-08-04T07:02:41Zen
dc.date.available2015-08-04T07:02:41Zen
dc.date.issued2012en
dc.identifier.isbn9783642334115en
dc.identifier.issn18684238en
dc.identifier.doi10.1007/978-3-642-33412-2_63en
dc.identifier.urihttp://hdl.handle.net/10754/564504en
dc.description.abstractProteins and their interactions are considered to play a significant role in many cellular processes. The identification of Protein-Protein interactions (PPIs) in human is an open research area. Many Databases, which contain information about experimentally and computationally detected human PPIs as well as their corresponding annotation data, have been developed. However, these databases contain many false positive interactions, are partial and only a few of them incorporate data from various sources. To overcome these limitations, we have developed HINT-KB (http://150.140.142.24:84/Default.aspx) which is a knowledge base that integrates data from various sources, provides a user-friendly interface for their retrieval, estimates a set of features of interest and computes a confidence score for every candidate protein interaction using a modern computational hybrid methodology. © 2012 IFIP International Federation for Information Processing.en
dc.publisherSpringer Science + Business Mediaen
dc.subjectGenetic Algorithmsen
dc.subjectHumanen
dc.subjectKalman Filtersen
dc.subjectKnowledge Baseen
dc.subjectPPI scoring methodsen
dc.subjectProtein-Protein Interactionsen
dc.titleHINT-KB: The human interactome knowledge baseen
dc.typeConference Paperen
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Divisionen
dc.contributor.departmentComputer Science Programen
dc.identifier.journalIFIP Advances in Information and Communication Technologyen
dc.conference.date27 September 2012 through 30 September 2012en
dc.conference.name8th International Workshop on Artificial Intelligence Applications and Innovations, AIAI 2012: AIAB, AIeIA, CISE, COPA, IIVC, ISQL, MHDW, and WADTMBen
dc.conference.locationHalkidikien
dc.contributor.institutionDepartment of Computer Engineering and Informatics, University of Patras, Greeceen
dc.contributor.institutionDepartment of Electrical Engineering-ESAT, SCD-SISTA, Katholieke Universiteit Leuven, Kasteelpark Arenberg 10, box 2446, 300, Leuven, Belgiumen
dc.contributor.institutionIBBT Future Health Department, Katholieke Universiteit Leuven, Kasteelpark Arenberg 10, box 2446, 300, Leuven, Belgiumen
dc.contributor.institutionDepartment of Information Management, Technological Institute of Kavala, Greeceen
dc.contributor.institutionDepartment of Social Work, School of Sciences of Health and Care, Technological Educational Institute of Patras, Greeceen
kaust.authorKleftogiannis, Dimitrios A.en
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