A half-ring GMR sensor for detection of magnetic beads immobilized on a circular micro-trap

Handle URI:
http://hdl.handle.net/10754/564452
Title:
A half-ring GMR sensor for detection of magnetic beads immobilized on a circular micro-trap
Authors:
Gooneratne, Chinthaka Pasan; Liang, Cai ( 0000-0002-5844-3432 ) ; Useinov, Arthur; Kosel, Jürgen ( 0000-0002-8998-8275 ) ; Giouroudi, Ioanna
Abstract:
Utilizing magnetic principles in biological immunoassays is an attractive option given its ability to remotely and non-invasively manipulate and detect cells tagged with micro/nano size superparamagnetic type beads and due to the fact that even the most complex biological immunoassays will have very little magnetic effect. The presence of magnetic beads can be detected by a magnetic sensor which quantifies the amount of target cells present in the immunoassay. In order to increase the detection rate a circular conducting micro-trap is employed to attract, trap and transport the magnetic beads to the sensing area. In this research we propose a half-ring spin valve type giant magnetoresistance (GMR) sensor for the measurement of stray fields produced by 2 μm magnetic beads which are around the circular micro-trap. A couple of half-ring GMR sensors can be used to cover the entire circular border width, in order to detect the majority of the immobilized magnetic beads. Analytical and numerical analysis leading towards the fabrication of the half-ring GMR sensor are presented. DC characterization of the fabricated sensor showed a magnetoresistance of 5.9 %. Experimental results showed that the half-ring GMR sensor detected the presence of 2 μm magnetic beads. Hence, half-ring GMR sensors integrated with a circular micro-trap have great potential to be used as an effective disease diagnostic device. © 2011 IEEE.
KAUST Department:
Physical Sciences and Engineering (PSE) Division; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division; Electrical Engineering Program; Sensing, Magnetism and Microsystems Lab
Publisher:
Institute of Electrical and Electronics Engineers (IEEE)
Journal:
2011 Fifth International Conference on Sensing Technology
Conference/Event name:
2011 5th International Conference on Sensing Technology, ICST 2011
Issue Date:
Nov-2011
DOI:
10.1109/ICSensT.2011.6136942
Type:
Conference Paper
ISSN:
21568065
ISBN:
9781457701672
Appears in Collections:
Conference Papers; Physical Sciences and Engineering (PSE) Division; Electrical Engineering Program; Sensing, Magnetism and Microsystems Lab; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorGooneratne, Chinthaka Pasanen
dc.contributor.authorLiang, Caien
dc.contributor.authorUseinov, Arthuren
dc.contributor.authorKosel, Jürgenen
dc.contributor.authorGiouroudi, Ioannaen
dc.date.accessioned2015-08-04T07:01:21Zen
dc.date.available2015-08-04T07:01:21Zen
dc.date.issued2011-11en
dc.identifier.isbn9781457701672en
dc.identifier.issn21568065en
dc.identifier.doi10.1109/ICSensT.2011.6136942en
dc.identifier.urihttp://hdl.handle.net/10754/564452en
dc.description.abstractUtilizing magnetic principles in biological immunoassays is an attractive option given its ability to remotely and non-invasively manipulate and detect cells tagged with micro/nano size superparamagnetic type beads and due to the fact that even the most complex biological immunoassays will have very little magnetic effect. The presence of magnetic beads can be detected by a magnetic sensor which quantifies the amount of target cells present in the immunoassay. In order to increase the detection rate a circular conducting micro-trap is employed to attract, trap and transport the magnetic beads to the sensing area. In this research we propose a half-ring spin valve type giant magnetoresistance (GMR) sensor for the measurement of stray fields produced by 2 μm magnetic beads which are around the circular micro-trap. A couple of half-ring GMR sensors can be used to cover the entire circular border width, in order to detect the majority of the immobilized magnetic beads. Analytical and numerical analysis leading towards the fabrication of the half-ring GMR sensor are presented. DC characterization of the fabricated sensor showed a magnetoresistance of 5.9 %. Experimental results showed that the half-ring GMR sensor detected the presence of 2 μm magnetic beads. Hence, half-ring GMR sensors integrated with a circular micro-trap have great potential to be used as an effective disease diagnostic device. © 2011 IEEE.en
dc.publisherInstitute of Electrical and Electronics Engineers (IEEE)en
dc.subjectGMR sensoren
dc.subjectimmunoassayen
dc.subjectmagnetic beadsen
dc.subjectmagnetic forceen
dc.subjectmicrotrapen
dc.titleA half-ring GMR sensor for detection of magnetic beads immobilized on a circular micro-trapen
dc.typeConference Paperen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Divisionen
dc.contributor.departmentElectrical Engineering Programen
dc.contributor.departmentSensing, Magnetism and Microsystems Laben
dc.identifier.journal2011 Fifth International Conference on Sensing Technologyen
dc.conference.date28 November 2011 through 1 December 2011en
dc.conference.name2011 5th International Conference on Sensing Technology, ICST 2011en
dc.conference.locationPalmerston Northen
dc.contributor.institutionInstitute of Sensor and Actuator Systems, Vienna University of Technology, Vienna 1040, Austriaen
kaust.authorGooneratne, Chinthaka Pasanen
kaust.authorLiang, Caien
kaust.authorUseinov, Arthuren
kaust.authorKosel, Jürgenen
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