Colorimetric peroxidase mimetic assay for uranyl detection in sea water

Handle URI:
http://hdl.handle.net/10754/564097
Title:
Colorimetric peroxidase mimetic assay for uranyl detection in sea water
Authors:
Zhang, Dingyuan; Chen, Zhuo ( 0000-0002-8433-8695 ) ; Omar, Haneen; Deng, Lin ( 0000-0001-8954-5610 ) ; Khashab, Niveen M. ( 0000-0003-2728-0666 )
Abstract:
Uranyl (UO2 2+) is a form of uranium in aqueous solution that represents the greatest risk to human health because of its bioavailability. Different sensing techniques have been used with very sensitive detection limits especially the recently reported uranyl-specific DNAzymes systems. However, to the best of our knowledge, few efficient detection methods have been reported for uranyl sensing in seawater. Herein, gold nanoclusters (AuNCs) are employed in an efficient spectroscopic method to detect uranyl ion (UO2 2+) with a detection limit of 1.86 ÎM. In the absence of UO2 2+, the BSA-stabilized AuNCs (BSA-AuNCs) showed an intrinsic peroxidase-like activity. In the presence of UO2 2+, this activity can be efficiently restrained. The preliminary quenching mechanism and selectivity of UO2 2+ was also investigated and compared with other ions. This design strategy could be useful in understanding the binding affinity of protein-stabilized AuNCs to UO2 2+ and consequently prompt the recycling of UO2 2+ from seawater.
KAUST Department:
Advanced Membranes and Porous Materials Research Center; Smart Hybrid Materials (SHMs) lab; Physical Sciences and Engineering (PSE) Division; Chemical Science Program
Publisher:
American Chemical Society (ACS)
Journal:
ACS Applied Materials & Interfaces
Issue Date:
4-Mar-2015
DOI:
10.1021/am507361x
Type:
Article
ISSN:
19448244
Sponsors:
The authors gratefully acknowledge King Abdullah University of Science and Technology (KAUST) for the support of this work.
Appears in Collections:
Articles; Advanced Membranes and Porous Materials Research Center; Physical Sciences and Engineering (PSE) Division; Controlled Release and Delivery Laboratory; Chemical Science Program

Full metadata record

DC FieldValue Language
dc.contributor.authorZhang, Dingyuanen
dc.contributor.authorChen, Zhuoen
dc.contributor.authorOmar, Haneenen
dc.contributor.authorDeng, Linen
dc.contributor.authorKhashab, Niveen M.en
dc.date.accessioned2015-08-03T12:32:02Zen
dc.date.available2015-08-03T12:32:02Zen
dc.date.issued2015-03-04en
dc.identifier.issn19448244en
dc.identifier.doi10.1021/am507361xen
dc.identifier.urihttp://hdl.handle.net/10754/564097en
dc.description.abstractUranyl (UO2 2+) is a form of uranium in aqueous solution that represents the greatest risk to human health because of its bioavailability. Different sensing techniques have been used with very sensitive detection limits especially the recently reported uranyl-specific DNAzymes systems. However, to the best of our knowledge, few efficient detection methods have been reported for uranyl sensing in seawater. Herein, gold nanoclusters (AuNCs) are employed in an efficient spectroscopic method to detect uranyl ion (UO2 2+) with a detection limit of 1.86 ÎM. In the absence of UO2 2+, the BSA-stabilized AuNCs (BSA-AuNCs) showed an intrinsic peroxidase-like activity. In the presence of UO2 2+, this activity can be efficiently restrained. The preliminary quenching mechanism and selectivity of UO2 2+ was also investigated and compared with other ions. This design strategy could be useful in understanding the binding affinity of protein-stabilized AuNCs to UO2 2+ and consequently prompt the recycling of UO2 2+ from seawater.en
dc.description.sponsorshipThe authors gratefully acknowledge King Abdullah University of Science and Technology (KAUST) for the support of this work.en
dc.publisherAmerican Chemical Society (ACS)en
dc.subjectgold nanoclustersen
dc.subjectperoxidase mimeticen
dc.subjectproteinsen
dc.subjectseawateren
dc.subjectsensorsen
dc.subjecturanylen
dc.titleColorimetric peroxidase mimetic assay for uranyl detection in sea wateren
dc.typeArticleen
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Centeren
dc.contributor.departmentSmart Hybrid Materials (SHMs) laben
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.contributor.departmentChemical Science Programen
dc.identifier.journalACS Applied Materials & Interfacesen
kaust.authorZhang, Dingyuanen
kaust.authorChen, Zhuoen
kaust.authorDeng, Linen
kaust.authorKhashab, Niveen M.en
kaust.authorOmar, Haneenen
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