Networks of neuroblastoma cells on porous silicon substrates reveal a small world topology

Handle URI:
http://hdl.handle.net/10754/563944
Title:
Networks of neuroblastoma cells on porous silicon substrates reveal a small world topology
Authors:
Marinaro, Giovanni; La Rocca, Rosanna; Toma, Andrea; Barberio, Marianna; Cancedda, Laura; Di Fabrizio, Enzo M. ( 0000-0001-5886-4678 ) ; Decuzzi, Paolo C W; Gentile, Francesco T.
Abstract:
The human brain is a tightly interweaving network of neural cells where the complexity of the network is given by the large number of its constituents and its architecture. The topological structure of neurons in the brain translates into its increased computational capabilities, low energy consumption, and nondeterministic functions, which differentiate human behavior from artificial computational schemes. In this manuscript, we fabricated porous silicon chips with a small pore size ranging from 8 to 75 nm and large fractal dimensions up to Df ∼ 2.8. In culturing neuroblastoma N2A cells on the described substrates, we found that those cells adhere more firmly to and proliferate on the porous surfaces compared to the conventional nominally flat silicon substrates, which were used as controls. More importantly, we observed that N2A cells on the porous substrates create highly clustered, small world topology patterns. We conjecture that neurons with a similar architecture may elaborate information more efficiently than in random or regular grids. Moreover, we hypothesize that systems of neurons on nano-scale geometry evolve in time to form networks in which the propagation of information is maximized. This journal is
KAUST Department:
Physical Sciences and Engineering (PSE) Division; Materials Science and Engineering Program
Publisher:
Royal Society of Chemistry (RSC)
Journal:
Integr. Biol.
Issue Date:
2015
DOI:
10.1039/c4ib00216d
Type:
Article
ISSN:
17579694
Sponsors:
This work was partially funded from the EU Commission, the European Social Fund and the Calabria Region (POR Calabria FSE 2007-2013) and from the Italian Ministry of Health under the project "Cancer biomarker detection using micro-structured/super-hydrophobic surfaces and advanced spectroscopy techniques'' (Project no. GR-2010-2320665).
Appears in Collections:
Articles; Physical Sciences and Engineering (PSE) Division; Materials Science and Engineering Program

Full metadata record

DC FieldValue Language
dc.contributor.authorMarinaro, Giovannien
dc.contributor.authorLa Rocca, Rosannaen
dc.contributor.authorToma, Andreaen
dc.contributor.authorBarberio, Mariannaen
dc.contributor.authorCancedda, Lauraen
dc.contributor.authorDi Fabrizio, Enzo M.en
dc.contributor.authorDecuzzi, Paolo C Wen
dc.contributor.authorGentile, Francesco T.en
dc.date.accessioned2015-08-03T12:20:24Zen
dc.date.available2015-08-03T12:20:24Zen
dc.date.issued2015en
dc.identifier.issn17579694en
dc.identifier.doi10.1039/c4ib00216den
dc.identifier.urihttp://hdl.handle.net/10754/563944en
dc.description.abstractThe human brain is a tightly interweaving network of neural cells where the complexity of the network is given by the large number of its constituents and its architecture. The topological structure of neurons in the brain translates into its increased computational capabilities, low energy consumption, and nondeterministic functions, which differentiate human behavior from artificial computational schemes. In this manuscript, we fabricated porous silicon chips with a small pore size ranging from 8 to 75 nm and large fractal dimensions up to Df ∼ 2.8. In culturing neuroblastoma N2A cells on the described substrates, we found that those cells adhere more firmly to and proliferate on the porous surfaces compared to the conventional nominally flat silicon substrates, which were used as controls. More importantly, we observed that N2A cells on the porous substrates create highly clustered, small world topology patterns. We conjecture that neurons with a similar architecture may elaborate information more efficiently than in random or regular grids. Moreover, we hypothesize that systems of neurons on nano-scale geometry evolve in time to form networks in which the propagation of information is maximized. This journal isen
dc.description.sponsorshipThis work was partially funded from the EU Commission, the European Social Fund and the Calabria Region (POR Calabria FSE 2007-2013) and from the Italian Ministry of Health under the project "Cancer biomarker detection using micro-structured/super-hydrophobic surfaces and advanced spectroscopy techniques'' (Project no. GR-2010-2320665).en
dc.publisherRoyal Society of Chemistry (RSC)en
dc.titleNetworks of neuroblastoma cells on porous silicon substrates reveal a small world topologyen
dc.typeArticleen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.contributor.departmentMaterials Science and Engineering Programen
dc.identifier.journalIntegr. Biol.en
dc.contributor.institutionIstituto Italiano di Tecnologia, Via Morego 30Genova, Italyen
dc.contributor.institutionEuropean Synchrotron Radiation Facility, CS40220Grenoble Cedex 9, Franceen
dc.contributor.institutionDepartment of Physics, Università della Calabria, Via P. Bucci 33cRende, Italyen
dc.contributor.institutionDepartment of Experimental and Clinical Medicine, University of Magna GraeciaCatanzaro, Italyen
dc.contributor.institutionDepartment of Nanomedicine, Methodist Hospital Research InstituteHouston, TX, United Statesen
dc.contributor.institutionDepartment of Electrical Engineering and Information Technology, University of NaplesNaples, Italyen
kaust.authorDi Fabrizio, Enzo M.en
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