Synthesis of an amphiphilic dendrimer-like block copolymer and its application on drug delivery

Handle URI:
http://hdl.handle.net/10754/563806
Title:
Synthesis of an amphiphilic dendrimer-like block copolymer and its application on drug delivery
Authors:
Wang, Shuaipeng; Song, Xiaowan; Feng, Xiaoshuang; Chen, Peng; Qian, Jiasheng; Xia, Ru; Miao, Jibin
Abstract:
Dendrimer-like amphiphilic copolymer is a kind of three-dimensional spherical structure polymer. An amphiphilic dendrimer-like diblock copolymer, PEEGE-G2-b-PEO(OH)12, constituted of a hydrophobic poly(ethoxyethyl glycidol ether) inner core and a hydrophilic poly(ethylene oxide) outer layer, has been successfully synthesized by the living anionic ring-opening polymerization method. The intermediates and targeted products were characterized with 1H NMR spectroscopy and gel permeation chromatography. The application on drug delivery of dendrimer-like diblock copolymer PEEGE-G2-b-PEO(OH)12 using DOX as a model drug was also studied. The drug loading content and encapsulation efficiency were found at 13.07% and 45.75%, respectively. In vitro release experiment results indicated that the drug-loaded micelles exhibited a sustained release behavior under acidic media.
KAUST Department:
Physical Sciences and Engineering (PSE) Division
Publisher:
AIP Publishing
Journal:
Chinese Journal of Chemical Physics
Issue Date:
27-Oct-2014
DOI:
10.1063/1674-0068/27/05/587-592
Type:
Article
ISSN:
16740068
Sponsors:
This work was supported by the National Natural Science Foundation of China (No.20804001, No.20974001, No.21174001, and No.51273001), the 211 Project, and the Incubation Fund for Excellent Young Researcher of Anhui University.
Appears in Collections:
Articles; Physical Sciences and Engineering (PSE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorWang, Shuaipengen
dc.contributor.authorSong, Xiaowanen
dc.contributor.authorFeng, Xiaoshuangen
dc.contributor.authorChen, Pengen
dc.contributor.authorQian, Jiashengen
dc.contributor.authorXia, Ruen
dc.contributor.authorMiao, Jibinen
dc.date.accessioned2015-08-03T12:10:46Zen
dc.date.available2015-08-03T12:10:46Zen
dc.date.issued2014-10-27en
dc.identifier.issn16740068en
dc.identifier.doi10.1063/1674-0068/27/05/587-592en
dc.identifier.urihttp://hdl.handle.net/10754/563806en
dc.description.abstractDendrimer-like amphiphilic copolymer is a kind of three-dimensional spherical structure polymer. An amphiphilic dendrimer-like diblock copolymer, PEEGE-G2-b-PEO(OH)12, constituted of a hydrophobic poly(ethoxyethyl glycidol ether) inner core and a hydrophilic poly(ethylene oxide) outer layer, has been successfully synthesized by the living anionic ring-opening polymerization method. The intermediates and targeted products were characterized with 1H NMR spectroscopy and gel permeation chromatography. The application on drug delivery of dendrimer-like diblock copolymer PEEGE-G2-b-PEO(OH)12 using DOX as a model drug was also studied. The drug loading content and encapsulation efficiency were found at 13.07% and 45.75%, respectively. In vitro release experiment results indicated that the drug-loaded micelles exhibited a sustained release behavior under acidic media.en
dc.description.sponsorshipThis work was supported by the National Natural Science Foundation of China (No.20804001, No.20974001, No.21174001, and No.51273001), the 211 Project, and the Incubation Fund for Excellent Young Researcher of Anhui University.en
dc.publisherAIP Publishingen
dc.subjectAmphiphilic diblock copolymeren
dc.subjectAnionic ring opening polymerizationen
dc.subjectDendrimer-like copolymeren
dc.subjectDrug deliveryen
dc.subjectLiving polymerizationen
dc.titleSynthesis of an amphiphilic dendrimer-like block copolymer and its application on drug deliveryen
dc.typeArticleen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.identifier.journalChinese Journal of Chemical Physicsen
dc.contributor.institutionSchool of Chemistry and Chemical Engineering, Anhui University, Key Laboratory of Environment-friendly Polymer Materials of Anhui ProvinceHefei, Chinaen
kaust.authorFeng, Xiaoshuangen
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