Biomimetic block copolymer particles with gated nanopores and ultrahigh protein sorption capacity

Handle URI:
http://hdl.handle.net/10754/563600
Title:
Biomimetic block copolymer particles with gated nanopores and ultrahigh protein sorption capacity
Authors:
Yu, Haizhou; Qiu, Xiaoyan; Nunes, Suzana Pereira ( 0000-0002-3669-138X ) ; Peinemann, Klaus-Viktor ( 0000-0003-0309-9598 )
Abstract:
The design of micro-or nanoparticles that can encapsulate sensitive molecules such as drugs, hormones, proteins or peptides is of increasing importance for applications in biotechnology and medicine. Examples are micelles, liposomes and vesicles. The tiny and, in most cases, hollow spheres are used as vehicles for transport and controlled administration of pharmaceutical drugs or nutrients. Here we report a simple strategy to fabricate microspheres by block copolymer self-assembly. The microsphere particles have monodispersed nanopores that can act as pH-responsive gates. They contain a highly porous internal structure, which is analogous to the Schwarz P structure. The internal porosity of the particles contributes to their high sorption capacity and sustained release behaviour. We successfully separated similarly sized proteins using these particles. The ease of particle fabrication by macrophase separation and self-assembly, and the robustness of the particles makes them ideal for sorption, separation, transport and sustained delivery of pharmaceutical substances. © 2014 Macmillan Publishers Limited.
KAUST Department:
Advanced Membranes and Porous Materials Research Center; Water Desalination and Reuse Research Center (WDRC); Biological and Environmental Sciences and Engineering (BESE) Division; Environmental Science and Engineering Program; Physical Sciences and Engineering (PSE) Division; Chemical and Biological Engineering Program; Nanostructured Polymeric Membrane Lab
Publisher:
Nature Publishing Group
Journal:
Nature Communications
Issue Date:
17-Jun-2014
DOI:
10.1038/ncomms5110
Type:
Article
ISSN:
20411723
Sponsors:
The authors gratefully acknowledge the financial support from King Abdullah University of Science and Technology (KAUST), and also thank Dr Ali Reza Behzad and Dr Lan Zhao from the Advanced Nanofabrication, Imaging and Characterization Lab at KAUST for help with the Cryo-FESEM and SEM.
Appears in Collections:
Articles; Advanced Membranes and Porous Materials Research Center; Environmental Science and Engineering Program; Physical Sciences and Engineering (PSE) Division; Chemical and Biological Engineering Program; Water Desalination and Reuse Research Center (WDRC); Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorYu, Haizhouen
dc.contributor.authorQiu, Xiaoyanen
dc.contributor.authorNunes, Suzana Pereiraen
dc.contributor.authorPeinemann, Klaus-Viktoren
dc.date.accessioned2015-08-03T11:55:23Zen
dc.date.available2015-08-03T11:55:23Zen
dc.date.issued2014-06-17en
dc.identifier.issn20411723en
dc.identifier.doi10.1038/ncomms5110en
dc.identifier.urihttp://hdl.handle.net/10754/563600en
dc.description.abstractThe design of micro-or nanoparticles that can encapsulate sensitive molecules such as drugs, hormones, proteins or peptides is of increasing importance for applications in biotechnology and medicine. Examples are micelles, liposomes and vesicles. The tiny and, in most cases, hollow spheres are used as vehicles for transport and controlled administration of pharmaceutical drugs or nutrients. Here we report a simple strategy to fabricate microspheres by block copolymer self-assembly. The microsphere particles have monodispersed nanopores that can act as pH-responsive gates. They contain a highly porous internal structure, which is analogous to the Schwarz P structure. The internal porosity of the particles contributes to their high sorption capacity and sustained release behaviour. We successfully separated similarly sized proteins using these particles. The ease of particle fabrication by macrophase separation and self-assembly, and the robustness of the particles makes them ideal for sorption, separation, transport and sustained delivery of pharmaceutical substances. © 2014 Macmillan Publishers Limited.en
dc.description.sponsorshipThe authors gratefully acknowledge the financial support from King Abdullah University of Science and Technology (KAUST), and also thank Dr Ali Reza Behzad and Dr Lan Zhao from the Advanced Nanofabrication, Imaging and Characterization Lab at KAUST for help with the Cryo-FESEM and SEM.en
dc.publisherNature Publishing Groupen
dc.titleBiomimetic block copolymer particles with gated nanopores and ultrahigh protein sorption capacityen
dc.typeArticleen
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Centeren
dc.contributor.departmentWater Desalination and Reuse Research Center (WDRC)en
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.contributor.departmentEnvironmental Science and Engineering Programen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.contributor.departmentChemical and Biological Engineering Programen
dc.contributor.departmentNanostructured Polymeric Membrane Laben
dc.identifier.journalNature Communicationsen
kaust.authorYu, Haizhouen
kaust.authorQiu, Xiaoyanen
kaust.authorNunes, Suzana Pereiraen
kaust.authorPeinemann, Klaus-Viktoren
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