Generation of tunable and pulsatile concentration gradients via microfluidic network

Handle URI:
http://hdl.handle.net/10754/563591
Title:
Generation of tunable and pulsatile concentration gradients via microfluidic network
Authors:
Zhou, Bingpu; Xu, Wei; Wang, Cong; Chau, Yeungyeung; Zeng, Xiping; Zhang, Xixiang ( 0000-0002-3478-6414 ) ; Shen, Rong; Wen, Weijia
Abstract:
We demonstrate a compact Polydimethylsiloxane microfluidic chip which can quickly generate ten different chemical concentrations simultaneously. The concentration magnitude of each branch can be flexibly regulated based on the flow rate ratios of the two injecting streams. The temporal/pulsatile concentration gradients are achieved by integrating on-chip pneumatic actuated valves controlled by the external signals. The temporal concentration gradients can also be tuned precisely by varying applied frequency and duty cycle of the trigger signal. It is believed that such microdevice will be potentially used for some application areas of producing stable chemical gradients as well as allowing fast, pulsatile gradient transformation in seconds.
KAUST Department:
KAUST-HKUST Micro/Nanofluidic Joint Laboratory; Advanced Nanofabrication, Imaging and Characterization Core Lab; Physical Sciences and Engineering (PSE) Division; Materials Science and Engineering Program
Publisher:
Springer Nature
Journal:
Microfluidics and Nanofluidics
Issue Date:
4-Jun-2014
DOI:
10.1007/s10404-014-1432-9
Type:
Article
ISSN:
16134982
Sponsors:
We would like to thank Prof. Andrew W. O. Poon's research group, of Department of Electronic and Computer Engineering in HKUST, for their assistance in COMSOL Multiphysics simulations. This publication is based on work partially supported by Award No. SA-C0040/UK-C0016, made by King Abdullah University of Science and Technology (KAUST), Hong Kong RGC Grants HKUST 604710 and 605411, and National Natural Science Foundation of China (Grant No. 11290165). The work is also partially supported by the Nanoscience and Nanotechnology Program at HKUST.
Appears in Collections:
Articles; Advanced Nanofabrication, Imaging and Characterization Core Lab; Physical Sciences and Engineering (PSE) Division; Materials Science and Engineering Program

Full metadata record

DC FieldValue Language
dc.contributor.authorZhou, Bingpuen
dc.contributor.authorXu, Weien
dc.contributor.authorWang, Congen
dc.contributor.authorChau, Yeungyeungen
dc.contributor.authorZeng, Xipingen
dc.contributor.authorZhang, Xixiangen
dc.contributor.authorShen, Rongen
dc.contributor.authorWen, Weijiaen
dc.date.accessioned2015-08-03T11:55:11Zen
dc.date.available2015-08-03T11:55:11Zen
dc.date.issued2014-06-04en
dc.identifier.issn16134982en
dc.identifier.doi10.1007/s10404-014-1432-9en
dc.identifier.urihttp://hdl.handle.net/10754/563591en
dc.description.abstractWe demonstrate a compact Polydimethylsiloxane microfluidic chip which can quickly generate ten different chemical concentrations simultaneously. The concentration magnitude of each branch can be flexibly regulated based on the flow rate ratios of the two injecting streams. The temporal/pulsatile concentration gradients are achieved by integrating on-chip pneumatic actuated valves controlled by the external signals. The temporal concentration gradients can also be tuned precisely by varying applied frequency and duty cycle of the trigger signal. It is believed that such microdevice will be potentially used for some application areas of producing stable chemical gradients as well as allowing fast, pulsatile gradient transformation in seconds.en
dc.description.sponsorshipWe would like to thank Prof. Andrew W. O. Poon's research group, of Department of Electronic and Computer Engineering in HKUST, for their assistance in COMSOL Multiphysics simulations. This publication is based on work partially supported by Award No. SA-C0040/UK-C0016, made by King Abdullah University of Science and Technology (KAUST), Hong Kong RGC Grants HKUST 604710 and 605411, and National Natural Science Foundation of China (Grant No. 11290165). The work is also partially supported by the Nanoscience and Nanotechnology Program at HKUST.en
dc.publisherSpringer Natureen
dc.titleGeneration of tunable and pulsatile concentration gradients via microfluidic networken
dc.typeArticleen
dc.contributor.departmentKAUST-HKUST Micro/Nanofluidic Joint Laboratoryen
dc.contributor.departmentAdvanced Nanofabrication, Imaging and Characterization Core Laben
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.contributor.departmentMaterials Science and Engineering Programen
dc.identifier.journalMicrofluidics and Nanofluidicsen
dc.contributor.institutionInstitute of Physics, Chinese Academy of SciencesBeijing, Chinaen
dc.contributor.institutionDepartment of Physics, The Hong Kong University of Science and Technology, Clear Water BayKowloon, Hong Kongen
kaust.authorZhang, Xixiangen
kaust.authorXu, Weien
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