Effects of short-term niacin treatment on plasma lipoprotein concentrations in African green monkeys (Chlorocebus aethiops)

Handle URI:
http://hdl.handle.net/10754/563347
Title:
Effects of short-term niacin treatment on plasma lipoprotein concentrations in African green monkeys (Chlorocebus aethiops)
Authors:
Chauke, Chesa G.; Arieff, Zainunisha; Kaur, Mandeep; Seier, Jürgen V.
Abstract:
Niacin is the most effective drug available for raising levels of high-density lipoprotein (HDL) cholesterol. To evaluate its effects on plasma lipid concentrations, the authors administered a low dose of niacin to healthy, adult, female African green monkeys for 3 months. In the treated monkeys, low-density lipoprotein cholesterol concentrations decreased by 43% from baseline, whereas concentrations of HDL cholesterol and apolipoprotein A-I increased by 49% and 34%, respectively. The results suggest that in this primate model, a low dose of niacin can effectively increase concentrations of HDL cholesterol.©2014 Nature America, Inc. All rights reserved.
KAUST Department:
Computational Bioscience Research Center (CBRC)
Publisher:
Springer Nature
Journal:
Lab Animal
Issue Date:
22-Jan-2014
DOI:
10.1038/laban.424
PubMed ID:
24451360
Type:
Article
ISSN:
00937355
Appears in Collections:
Articles; Computational Bioscience Research Center (CBRC)

Full metadata record

DC FieldValue Language
dc.contributor.authorChauke, Chesa G.en
dc.contributor.authorArieff, Zainunishaen
dc.contributor.authorKaur, Mandeepen
dc.contributor.authorSeier, Jürgen V.en
dc.date.accessioned2015-08-03T11:46:19Zen
dc.date.available2015-08-03T11:46:19Zen
dc.date.issued2014-01-22en
dc.identifier.issn00937355en
dc.identifier.pmid24451360en
dc.identifier.doi10.1038/laban.424en
dc.identifier.urihttp://hdl.handle.net/10754/563347en
dc.description.abstractNiacin is the most effective drug available for raising levels of high-density lipoprotein (HDL) cholesterol. To evaluate its effects on plasma lipid concentrations, the authors administered a low dose of niacin to healthy, adult, female African green monkeys for 3 months. In the treated monkeys, low-density lipoprotein cholesterol concentrations decreased by 43% from baseline, whereas concentrations of HDL cholesterol and apolipoprotein A-I increased by 49% and 34%, respectively. The results suggest that in this primate model, a low dose of niacin can effectively increase concentrations of HDL cholesterol.©2014 Nature America, Inc. All rights reserved.en
dc.publisherSpringer Natureen
dc.titleEffects of short-term niacin treatment on plasma lipoprotein concentrations in African green monkeys (Chlorocebus aethiops)en
dc.typeArticleen
dc.contributor.departmentComputational Bioscience Research Center (CBRC)en
dc.identifier.journalLab Animalen
dc.contributor.institutionMedical Research Council Primate Unit, Tygerberg, South Africaen
dc.contributor.institutionBiotechnology Department, University of the Western Cape, Cape Town, South Africaen
kaust.authorKaur, Mandeepen

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