Three-dimensional parallelization of microfluidic droplet generators for a litre per hour volume production of single emulsions

Handle URI:
http://hdl.handle.net/10754/563224
Title:
Three-dimensional parallelization of microfluidic droplet generators for a litre per hour volume production of single emulsions
Authors:
Conchouso Gonzalez, David ( 0000-0002-9788-0977 ) ; Castro, David; Khan, Saif; Foulds, Ian G.
Abstract:
This paper looks at the design, fabrication and characterization of stackable microfluidic emulsion generators, with coefficients of variation as low as ~6% and with production rates as high as ~1 L h-1. This work reports the highest throughput reported in the literature for a microfluidic device with simultaneous operation of liquid-liquid droplet generators. The device was achieved by stacking several layers of 128 flow-focusing droplet generators, organized in a circular array. These layers are interconnected via through-holes and fed with designated fractal distribution networks. The proposed layers were milled on poly(methylmethacrylate) (PMMA) sheets and the stack was thermo-compression bonded to create a three-dimensional device with a high density of generators and an integrated hydraulic manifold. The effect of stacking multiple layers was studied and the results show that fabrication accuracy has a greater impact on the dispersity of the emulsion than the addition of more layers to the stack. Particle crystallization of drugs was also demonstrated as a possible application of this technology in industry. © 2014 the Partner Organisations.
KAUST Department:
Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division; Electromechanical Microsystems & Polymer Integration Research Lab (EMPIRe)
Publisher:
Royal Society of Chemistry (RSC)
Journal:
Lab on a Chip
Issue Date:
2014
DOI:
10.1039/c4lc00379a
Type:
Article
ISSN:
14730197
Appears in Collections:
Articles; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorConchouso Gonzalez, Daviden
dc.contributor.authorCastro, Daviden
dc.contributor.authorKhan, Saifen
dc.contributor.authorFoulds, Ian G.en
dc.date.accessioned2015-08-03T11:43:33Zen
dc.date.available2015-08-03T11:43:33Zen
dc.date.issued2014en
dc.identifier.issn14730197en
dc.identifier.doi10.1039/c4lc00379aen
dc.identifier.urihttp://hdl.handle.net/10754/563224en
dc.description.abstractThis paper looks at the design, fabrication and characterization of stackable microfluidic emulsion generators, with coefficients of variation as low as ~6% and with production rates as high as ~1 L h-1. This work reports the highest throughput reported in the literature for a microfluidic device with simultaneous operation of liquid-liquid droplet generators. The device was achieved by stacking several layers of 128 flow-focusing droplet generators, organized in a circular array. These layers are interconnected via through-holes and fed with designated fractal distribution networks. The proposed layers were milled on poly(methylmethacrylate) (PMMA) sheets and the stack was thermo-compression bonded to create a three-dimensional device with a high density of generators and an integrated hydraulic manifold. The effect of stacking multiple layers was studied and the results show that fabrication accuracy has a greater impact on the dispersity of the emulsion than the addition of more layers to the stack. Particle crystallization of drugs was also demonstrated as a possible application of this technology in industry. © 2014 the Partner Organisations.en
dc.publisherRoyal Society of Chemistry (RSC)en
dc.titleThree-dimensional parallelization of microfluidic droplet generators for a litre per hour volume production of single emulsionsen
dc.typeArticleen
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Divisionen
dc.contributor.departmentElectromechanical Microsystems & Polymer Integration Research Lab (EMPIRe)en
dc.identifier.journalLab on a Chipen
dc.contributor.institutionNational University of Singapore, Department of Chemical and Bimolecular Engineering, 4 Engineering Drive 4 E5-02-28, 117576 Singapore, Singaporeen
dc.contributor.institutionUniversity of British Columbia, Okanagan, Canadaen
kaust.authorFoulds, Ian G.en
kaust.authorConchouso Gonzalez, Daviden
kaust.authorCastro, Daviden
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