Selective on site separation and detection of molecules in diluted solutions with super-hydrophobic clusters of plasmonic nanoparticles

Handle URI:
http://hdl.handle.net/10754/563217
Title:
Selective on site separation and detection of molecules in diluted solutions with super-hydrophobic clusters of plasmonic nanoparticles
Authors:
Gentile, Francesco T.; Coluccio, Maria Laura; Proietti Zaccaria, Remo; Francardi, Marco; Cojoc, Gheorghe; Perozziello, Gerardo; Raimondo, Raffaella; Candeloro, Patrizio; Di Fabrizio, Enzo M. ( 0000-0001-5886-4678 )
Abstract:
Super-hydrophobic surfaces are bio-inspired interfaces with a superficial texture that, in its most common evolution, is formed by a periodic lattice of silicon micro-pillars. Similar surfaces reveal superior properties compared to conventional flat surfaces, including very low friction coefficients. In this work, we modified meso-porous silicon micro-pillars to incorporate networks of metal nano-particles into the porous matrix. In doing so, we obtained a multifunctional-hierarchical system in which (i) at a larger micrometric scale, the super-hydrophobic pillars bring the molecules dissolved in an ultralow-concentration droplet to the active sites of the device, (ii) at an intermediate meso-scale, the meso-porous silicon film adsorbs the low molecular weight content of the solution and, (iii) at a smaller nanometric scale, the aggregates of silver nano-particles would measure the target molecules with unprecedented sensitivity. In the results, we demonstrated how this scheme can be utilized to isolate and detect small molecules in a diluted solution in very low abundance ranges. The presented platform, coupled to Raman or other spectroscopy techniques, is a realistic candidate for the protein expression profiling of biological fluids. © 2014 the Partner Organisations.
KAUST Department:
Physical Sciences and Engineering (PSE) Division; Materials Science and Engineering Program
Publisher:
Royal Society of Chemistry (RSC)
Journal:
Nanoscale
Issue Date:
2014
DOI:
10.1039/c4nr00796d
Type:
Article
ISSN:
20403364
Sponsors:
This work has been partially funded by the EU Commission, the European Social Fund and the Calabria Region (POR Calabria FSE 2007-2013), from the Italian Minister of Health under the project "Cancer biomarker detection using micro-structured/super-hydrophobic surfaces and advanced spectroscopy techniques" (Project no. GR-2010-2320665), and the project "High throughput analysis of cancer cells for therapy evaluation by microfluidic platforms integrating plasmonic nanodevices" (Project no. GR-2010-2311677), and from the Cariplo Foundation under the project "New Frontiers in Plasmonic Nano-sensing" (Grant no. 2011-0338).
Appears in Collections:
Articles; Physical Sciences and Engineering (PSE) Division; Materials Science and Engineering Program

Full metadata record

DC FieldValue Language
dc.contributor.authorGentile, Francesco T.en
dc.contributor.authorColuccio, Maria Lauraen
dc.contributor.authorProietti Zaccaria, Remoen
dc.contributor.authorFrancardi, Marcoen
dc.contributor.authorCojoc, Gheorgheen
dc.contributor.authorPerozziello, Gerardoen
dc.contributor.authorRaimondo, Raffaellaen
dc.contributor.authorCandeloro, Patrizioen
dc.contributor.authorDi Fabrizio, Enzo M.en
dc.date.accessioned2015-08-03T11:43:22Zen
dc.date.available2015-08-03T11:43:22Zen
dc.date.issued2014en
dc.identifier.issn20403364en
dc.identifier.doi10.1039/c4nr00796den
dc.identifier.urihttp://hdl.handle.net/10754/563217en
dc.description.abstractSuper-hydrophobic surfaces are bio-inspired interfaces with a superficial texture that, in its most common evolution, is formed by a periodic lattice of silicon micro-pillars. Similar surfaces reveal superior properties compared to conventional flat surfaces, including very low friction coefficients. In this work, we modified meso-porous silicon micro-pillars to incorporate networks of metal nano-particles into the porous matrix. In doing so, we obtained a multifunctional-hierarchical system in which (i) at a larger micrometric scale, the super-hydrophobic pillars bring the molecules dissolved in an ultralow-concentration droplet to the active sites of the device, (ii) at an intermediate meso-scale, the meso-porous silicon film adsorbs the low molecular weight content of the solution and, (iii) at a smaller nanometric scale, the aggregates of silver nano-particles would measure the target molecules with unprecedented sensitivity. In the results, we demonstrated how this scheme can be utilized to isolate and detect small molecules in a diluted solution in very low abundance ranges. The presented platform, coupled to Raman or other spectroscopy techniques, is a realistic candidate for the protein expression profiling of biological fluids. © 2014 the Partner Organisations.en
dc.description.sponsorshipThis work has been partially funded by the EU Commission, the European Social Fund and the Calabria Region (POR Calabria FSE 2007-2013), from the Italian Minister of Health under the project "Cancer biomarker detection using micro-structured/super-hydrophobic surfaces and advanced spectroscopy techniques" (Project no. GR-2010-2320665), and the project "High throughput analysis of cancer cells for therapy evaluation by microfluidic platforms integrating plasmonic nanodevices" (Project no. GR-2010-2311677), and from the Cariplo Foundation under the project "New Frontiers in Plasmonic Nano-sensing" (Grant no. 2011-0338).en
dc.publisherRoyal Society of Chemistry (RSC)en
dc.titleSelective on site separation and detection of molecules in diluted solutions with super-hydrophobic clusters of plasmonic nanoparticlesen
dc.typeArticleen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.contributor.departmentMaterials Science and Engineering Programen
dc.identifier.journalNanoscaleen
dc.contributor.institutionBioNEM, University Magna Graecia of Catanzaro, Catanzaro 88100, Italyen
dc.contributor.institutionIstituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italyen
dc.contributor.institutionMax Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germanyen
kaust.authorFrancardi, Marcoen
kaust.authorDi Fabrizio, Enzo M.en
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