"Nail" and "comb" effects of cholesterol modified NIPAm oligomers on cancer targeting liposomes

Handle URI:
http://hdl.handle.net/10754/563177
Title:
"Nail" and "comb" effects of cholesterol modified NIPAm oligomers on cancer targeting liposomes
Authors:
Li, Wengang ( 0000-0002-1838-8360 ) ; Deng, Lin ( 0000-0001-8954-5610 ) ; Moosa, Basem ( 0000-0002-2350-4100 ) ; Wang, Guangchao; Mashat, Afnan; Khashab, Niveen M. ( 0000-0003-2728-0666 )
Abstract:
Thermosensitive liposomes are a promising approach to controlled release and reduced drug cytotoxicity. Low molecular weight N-isopropylacrylamide (NIPAm) oligomers (NOs) with different architectures (main chain NOs (MCNOs) and side chain NOs (SCNOs)) were synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization and radical polymerization and then separately used to prepare thermosensitive liposomes. A more controlled and enhanced release was observed for both NO liposomes compared to pristine ones. Two release mechanisms depending on the oligomer architecture, namely "nail" for MCNOs and "comb" for SCNOs, are proposed. In addition to thermosensitivity, the cancer targeting property of NO liposomes was achieved by further biotinylation of the delivery system. © The Royal Society of Chemistry.
KAUST Department:
Advanced Membranes and Porous Materials Research Center; Smart Hybrid Materials (SHMs) lab; Advanced Nanofabrication, Imaging and Characterization Core Lab; Physical Sciences and Engineering (PSE) Division; Chemical Science Program; Core Labs; Environmental Science and Engineering Program
Publisher:
Royal Society of Chemistry (RSC)
Journal:
Biomaterials Science
Issue Date:
2014
DOI:
10.1039/c3bm60222b
Type:
Article
ISSN:
20474830
Sponsors:
This research is fully sponsored by King Abdullah University of Science and Technology (KAUST).
Appears in Collections:
Articles; Advanced Membranes and Porous Materials Research Center; Environmental Science and Engineering Program; Advanced Nanofabrication, Imaging and Characterization Core Lab; Physical Sciences and Engineering (PSE) Division; Controlled Release and Delivery Laboratory; Chemical Science Program

Full metadata record

DC FieldValue Language
dc.contributor.authorLi, Wengangen
dc.contributor.authorDeng, Linen
dc.contributor.authorMoosa, Basemen
dc.contributor.authorWang, Guangchaoen
dc.contributor.authorMashat, Afnanen
dc.contributor.authorKhashab, Niveen M.en
dc.date.accessioned2015-08-03T11:37:32Zen
dc.date.available2015-08-03T11:37:32Zen
dc.date.issued2014en
dc.identifier.issn20474830en
dc.identifier.doi10.1039/c3bm60222ben
dc.identifier.urihttp://hdl.handle.net/10754/563177en
dc.description.abstractThermosensitive liposomes are a promising approach to controlled release and reduced drug cytotoxicity. Low molecular weight N-isopropylacrylamide (NIPAm) oligomers (NOs) with different architectures (main chain NOs (MCNOs) and side chain NOs (SCNOs)) were synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization and radical polymerization and then separately used to prepare thermosensitive liposomes. A more controlled and enhanced release was observed for both NO liposomes compared to pristine ones. Two release mechanisms depending on the oligomer architecture, namely "nail" for MCNOs and "comb" for SCNOs, are proposed. In addition to thermosensitivity, the cancer targeting property of NO liposomes was achieved by further biotinylation of the delivery system. © The Royal Society of Chemistry.en
dc.description.sponsorshipThis research is fully sponsored by King Abdullah University of Science and Technology (KAUST).en
dc.publisherRoyal Society of Chemistry (RSC)en
dc.title"Nail" and "comb" effects of cholesterol modified NIPAm oligomers on cancer targeting liposomesen
dc.typeArticleen
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Centeren
dc.contributor.departmentSmart Hybrid Materials (SHMs) laben
dc.contributor.departmentAdvanced Nanofabrication, Imaging and Characterization Core Laben
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.contributor.departmentChemical Science Programen
dc.contributor.departmentCore Labsen
dc.contributor.departmentEnvironmental Science and Engineering Programen
dc.identifier.journalBiomaterials Scienceen
kaust.authorLi, Wengangen
kaust.authorDeng, Linen
kaust.authorMoosa, Basemen
kaust.authorWang, Guangchaoen
kaust.authorMashat, Afnanen
kaust.authorKhashab, Niveen M.en
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