The Hofmeister effect on nanodiamonds: How addition of ions provides superior drug loading platforms

Handle URI:
http://hdl.handle.net/10754/563165
Title:
The Hofmeister effect on nanodiamonds: How addition of ions provides superior drug loading platforms
Authors:
Guo, Yong; Li, Song ( 0000-0003-4463-733X ) ; Li, Wengang ( 0000-0002-1838-8360 ) ; Moosa, Basem ( 0000-0002-2350-4100 ) ; Khashab, Niveen M. ( 0000-0003-2728-0666 )
Abstract:
Colloidal nanodiamonds (NDs) have emerged as highly versatile platforms for the controlled delivery of therapeutics, proteins, DNA, and other assorted biological agents. The most common mechanism of drug loading onto the ND surface depends mainly on electrostatic interactions. Although a few reports have been published on using NaCl salt to increase the drug loading onto NDs, no comprehensive mechanistic study with a wide range of anions and cations has been reported. In this work, the Hofmeister effect of inorganic salts and amino acids with different isoelectric points was employed to understand the mechanism of doxorubicin (DOXH+) loading onto NDs with different sizes. Inorganic salts including NaCl, NaNO3, Na2SO4, KCl, CaCl2, (NH4)2SO4 and amino acids with an isoelectric point above 7 (positively charged at neutral pH) increase the DOXH+ loading onto small size NDs (SNDs, 5-10 nm). On the other hand, amino acids with an isoelectric point below 7 (negatively charged at neutral pH) increase the DOXH+ loading onto large size NDs (LNDs, 80-100 nm). © 2014 The Royal Society of Chemistry.
KAUST Department:
Numerical Porous Media SRI Center (NumPor); Smart Hybrid Materials (SHMs) lab; Advanced Membranes and Porous Materials Research Center; Physical Sciences and Engineering (PSE) Division; Chemical Science Program
Publisher:
Royal Society of Chemistry (RSC)
Journal:
Biomater. Sci.
Issue Date:
2014
DOI:
10.1039/c3bm60163c
Type:
Article
ISSN:
20474830
Sponsors:
We thank King Abdullah University of Science and Technology (KAUST) for the financial support.
Appears in Collections:
Articles; Advanced Membranes and Porous Materials Research Center; Physical Sciences and Engineering (PSE) Division; Controlled Release and Delivery Laboratory; Chemical Science Program

Full metadata record

DC FieldValue Language
dc.contributor.authorGuo, Yongen
dc.contributor.authorLi, Songen
dc.contributor.authorLi, Wengangen
dc.contributor.authorMoosa, Basemen
dc.contributor.authorKhashab, Niveen M.en
dc.date.accessioned2015-08-03T11:37:16Zen
dc.date.available2015-08-03T11:37:16Zen
dc.date.issued2014en
dc.identifier.issn20474830en
dc.identifier.doi10.1039/c3bm60163cen
dc.identifier.urihttp://hdl.handle.net/10754/563165en
dc.description.abstractColloidal nanodiamonds (NDs) have emerged as highly versatile platforms for the controlled delivery of therapeutics, proteins, DNA, and other assorted biological agents. The most common mechanism of drug loading onto the ND surface depends mainly on electrostatic interactions. Although a few reports have been published on using NaCl salt to increase the drug loading onto NDs, no comprehensive mechanistic study with a wide range of anions and cations has been reported. In this work, the Hofmeister effect of inorganic salts and amino acids with different isoelectric points was employed to understand the mechanism of doxorubicin (DOXH+) loading onto NDs with different sizes. Inorganic salts including NaCl, NaNO3, Na2SO4, KCl, CaCl2, (NH4)2SO4 and amino acids with an isoelectric point above 7 (positively charged at neutral pH) increase the DOXH+ loading onto small size NDs (SNDs, 5-10 nm). On the other hand, amino acids with an isoelectric point below 7 (negatively charged at neutral pH) increase the DOXH+ loading onto large size NDs (LNDs, 80-100 nm). © 2014 The Royal Society of Chemistry.en
dc.description.sponsorshipWe thank King Abdullah University of Science and Technology (KAUST) for the financial support.en
dc.publisherRoyal Society of Chemistry (RSC)en
dc.titleThe Hofmeister effect on nanodiamonds: How addition of ions provides superior drug loading platformsen
dc.typeArticleen
dc.contributor.departmentNumerical Porous Media SRI Center (NumPor)en
dc.contributor.departmentSmart Hybrid Materials (SHMs) laben
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Centeren
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.contributor.departmentChemical Science Programen
dc.identifier.journalBiomater. Sci.en
kaust.authorGuo, Yongen
kaust.authorLi, Songen
kaust.authorLi, Wengangen
kaust.authorMoosa, Basemen
kaust.authorKhashab, Niveen M.en
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