A calibration-free ammonia breath sensor using a quantum cascade laser with WMS 2f/1f

Handle URI:
http://hdl.handle.net/10754/563157
Title:
A calibration-free ammonia breath sensor using a quantum cascade laser with WMS 2f/1f
Authors:
Owen, Kyle; Farooq, Aamir ( 0000-0001-5296-2197 )
Abstract:
The amount of ammonia in exhaled breath has been linked to a variety of adverse medical conditions, including chronic kidney disease (CKD). The development of accurate, reliable breath sensors has the potential to improve medical care. Wavelength modulation spectroscopy with second harmonic normalized by the first harmonic (WMS 2f/1f) is a sensitive technique used in the development of calibration-free sensors. An ammonia gas sensor is designed and developed that uses a quantum cascade laser operating near 1,103.44 cm -1 and a multi-pass cell with an effective path length of 76.45 m. The sensor has a 7 ppbv detection limit and 5 % total uncertainty for breath measurements. The sensor was successfully used to detect ammonia in exhaled breath and compare healthy patients to patients diagnosed with CKD. © 2013 Springer-Verlag Berlin Heidelberg.
KAUST Department:
Clean Combustion Research Center; Physical Sciences and Engineering (PSE) Division; Mechanical Engineering Program; Chemical Kinetics & Laser Sensors Laboratory
Publisher:
Springer Nature
Journal:
Applied Physics B
Issue Date:
22-Dec-2013
DOI:
10.1007/s00340-013-5701-1
Type:
Article
ISSN:
09462171
Sponsors:
We would like to acknowledge the funding provided by King Abdullah University of Science and Technology (KAUST). We would also like to thank Dr. Mohammed Ayran, Dr. Mahmoud Saleh, and the staff of the Dialysis Center at the International Medical Center in Jeddah, Saudi Arabia for their medical consultation and assistance in collecting breath samples.
Appears in Collections:
Articles; Physical Sciences and Engineering (PSE) Division; Mechanical Engineering Program; Clean Combustion Research Center

Full metadata record

DC FieldValue Language
dc.contributor.authorOwen, Kyleen
dc.contributor.authorFarooq, Aamiren
dc.date.accessioned2015-08-03T11:37:06Zen
dc.date.available2015-08-03T11:37:06Zen
dc.date.issued2013-12-22en
dc.identifier.issn09462171en
dc.identifier.doi10.1007/s00340-013-5701-1en
dc.identifier.urihttp://hdl.handle.net/10754/563157en
dc.description.abstractThe amount of ammonia in exhaled breath has been linked to a variety of adverse medical conditions, including chronic kidney disease (CKD). The development of accurate, reliable breath sensors has the potential to improve medical care. Wavelength modulation spectroscopy with second harmonic normalized by the first harmonic (WMS 2f/1f) is a sensitive technique used in the development of calibration-free sensors. An ammonia gas sensor is designed and developed that uses a quantum cascade laser operating near 1,103.44 cm -1 and a multi-pass cell with an effective path length of 76.45 m. The sensor has a 7 ppbv detection limit and 5 % total uncertainty for breath measurements. The sensor was successfully used to detect ammonia in exhaled breath and compare healthy patients to patients diagnosed with CKD. © 2013 Springer-Verlag Berlin Heidelberg.en
dc.description.sponsorshipWe would like to acknowledge the funding provided by King Abdullah University of Science and Technology (KAUST). We would also like to thank Dr. Mohammed Ayran, Dr. Mahmoud Saleh, and the staff of the Dialysis Center at the International Medical Center in Jeddah, Saudi Arabia for their medical consultation and assistance in collecting breath samples.en
dc.publisherSpringer Natureen
dc.titleA calibration-free ammonia breath sensor using a quantum cascade laser with WMS 2f/1fen
dc.typeArticleen
dc.contributor.departmentClean Combustion Research Centeren
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.contributor.departmentMechanical Engineering Programen
dc.contributor.departmentChemical Kinetics & Laser Sensors Laboratoryen
dc.identifier.journalApplied Physics Ben
kaust.authorOwen, Kyleen
kaust.authorFarooq, Aamiren
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