Preliminary results on an innovative plasmonic device for macromolecules analysis and sequencing

Handle URI:
http://hdl.handle.net/10754/563069
Title:
Preliminary results on an innovative plasmonic device for macromolecules analysis and sequencing
Authors:
Francardi, Marco; Candeloro, Patrizio; Malara, Natalia Maria; Gentile, Francesco T.; Coluccio, Maria Laura; Perozziello, Gerardo; Gaggero, Aleesandro; De Angelis, Francesco De; Cherubini, Enrico; Di Fabrizio, Enzo M. ( 0000-0001-5886-4678 )
Abstract:
In this work we present the fabrication and theoretical simulation for a new device constituted by a on Substrate Plasmonic Antenna (SPA) combined with a bio-functionalized Atomic Force Microscopy (AFM) cantilever. This device could represent a new strategy to sequence and analyze a single protein or DNA. The idea is to use an SPA composed of an innovative "wedding cake"shaped grating (WCG), in order to excite a Surface Plasmon Polariton (SPP) mode, and a 30-tilted Plasmonic Antenna (PA), able to compress adiabatically the SPP until the tip. The Plasmonic device is placed inside an electrical contact that could be used to unfold protein molecules or DNA. A bio-functionalized AFM tip can be used to fish a single biological element and for alignment with the SPA. Then the unfolded element could be scanned close to the PA and a Tip Enhanced Raman Signal (TERS) can be recorded from the biomolecule. The spatial resolution is limited by the size of the radius of curvature of the antenna, which in this work is about 15 nm, while the vertical scanning is controlled by the piezoelectric of the AFM set up. In this work we demonstrate the possibility to fabricate this innovative plasmonic device and we report FDTD simulations of the innovative WCG. The FDTD simulations show the generation of a plasmonic mode that, coupled with the antenna, give rise to an adiabatic compression which produce an increase of the electric field of about 40 times. © 2013 Elsevier B.V. All rights reserved.
KAUST Department:
Physical Sciences and Engineering (PSE) Division; Materials Science and Engineering Program
Publisher:
Elsevier BV
Journal:
Microelectronic Engineering
Issue Date:
Nov-2013
DOI:
10.1016/j.mee.2013.02.096
Type:
Article
ISSN:
01679317
Sponsors:
We gratefully acknowledge financial support from Cariplo Foundation under the project "New Frontiers in Plasmonic Nanosensing" (Grant No. 2011-0338) granted to the nanotechnology laboratory of the Department of Experimental Medicine of the University "Magna Graecia" of Catanzaro.
Appears in Collections:
Articles; Physical Sciences and Engineering (PSE) Division; Materials Science and Engineering Program

Full metadata record

DC FieldValue Language
dc.contributor.authorFrancardi, Marcoen
dc.contributor.authorCandeloro, Patrizioen
dc.contributor.authorMalara, Natalia Mariaen
dc.contributor.authorGentile, Francesco T.en
dc.contributor.authorColuccio, Maria Lauraen
dc.contributor.authorPerozziello, Gerardoen
dc.contributor.authorGaggero, Aleesandroen
dc.contributor.authorDe Angelis, Francesco Deen
dc.contributor.authorCherubini, Enricoen
dc.contributor.authorDi Fabrizio, Enzo M.en
dc.date.accessioned2015-08-03T11:35:05Zen
dc.date.available2015-08-03T11:35:05Zen
dc.date.issued2013-11en
dc.identifier.issn01679317en
dc.identifier.doi10.1016/j.mee.2013.02.096en
dc.identifier.urihttp://hdl.handle.net/10754/563069en
dc.description.abstractIn this work we present the fabrication and theoretical simulation for a new device constituted by a on Substrate Plasmonic Antenna (SPA) combined with a bio-functionalized Atomic Force Microscopy (AFM) cantilever. This device could represent a new strategy to sequence and analyze a single protein or DNA. The idea is to use an SPA composed of an innovative "wedding cake"shaped grating (WCG), in order to excite a Surface Plasmon Polariton (SPP) mode, and a 30-tilted Plasmonic Antenna (PA), able to compress adiabatically the SPP until the tip. The Plasmonic device is placed inside an electrical contact that could be used to unfold protein molecules or DNA. A bio-functionalized AFM tip can be used to fish a single biological element and for alignment with the SPA. Then the unfolded element could be scanned close to the PA and a Tip Enhanced Raman Signal (TERS) can be recorded from the biomolecule. The spatial resolution is limited by the size of the radius of curvature of the antenna, which in this work is about 15 nm, while the vertical scanning is controlled by the piezoelectric of the AFM set up. In this work we demonstrate the possibility to fabricate this innovative plasmonic device and we report FDTD simulations of the innovative WCG. The FDTD simulations show the generation of a plasmonic mode that, coupled with the antenna, give rise to an adiabatic compression which produce an increase of the electric field of about 40 times. © 2013 Elsevier B.V. All rights reserved.en
dc.description.sponsorshipWe gratefully acknowledge financial support from Cariplo Foundation under the project "New Frontiers in Plasmonic Nanosensing" (Grant No. 2011-0338) granted to the nanotechnology laboratory of the Department of Experimental Medicine of the University "Magna Graecia" of Catanzaro.en
dc.publisherElsevier BVen
dc.subjectAdiabatic compressionen
dc.subjectAfmen
dc.subjectFdtd simulationsen
dc.subjectNano-fabricationen
dc.subjectPlasmon Polariton generationen
dc.subjectPlasmonic antennaen
dc.subjectProtein sequenzingen
dc.subjectTersen
dc.titlePreliminary results on an innovative plasmonic device for macromolecules analysis and sequencingen
dc.typeArticleen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.contributor.departmentMaterials Science and Engineering Programen
dc.identifier.journalMicroelectronic Engineeringen
dc.contributor.institutionInternational School for Advanced Studies (SISSA), Trieste 34136, Italyen
dc.contributor.institutionBionem Laboratory, University of Magna Graecia (UMG), Catanzaro 88100, Italyen
dc.contributor.institutionInstitute of Photonic and Nanotechnology (IFN-CNR), Rome 00100, Italyen
dc.contributor.institutionItalian Institute for Technologies (IIT), Genoa 16163, Italyen
kaust.authorDi Fabrizio, Enzo M.en
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