Inferring biological functions of guanylyl cyclases with computational methods

Handle URI:
http://hdl.handle.net/10754/562963
Title:
Inferring biological functions of guanylyl cyclases with computational methods
Authors:
Alquraishi, May Majed; Meier, Stuart Kurt
Abstract:
A number of studies have shown that functionally related genes are often co-expressed and that computational based co-expression analysis can be used to accurately identify functional relationships between genes and by inference, their encoded proteins. Here we describe how a computational based co-expression analysis can be used to link the function of a specific gene of interest to a defined cellular response. Using a worked example we demonstrate how this methodology is used to link the function of the Arabidopsis Wall-Associated Kinase-Like 10 gene, which encodes a functional guanylyl cyclase, to host responses to pathogens. © Springer Science+Business Media New York 2013.
KAUST Department:
Biological and Environmental Sciences and Engineering (BESE) Division
Publisher:
Humana Press
Journal:
Methods in Molecular Biology
Issue Date:
3-Sep-2013
DOI:
10.1007/978-1-62703-441-8-15
PubMed ID:
23681582
Type:
Article
ISSN:
10643745
ISBN:
9781627034401
Appears in Collections:
Articles; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorAlquraishi, May Majeden
dc.contributor.authorMeier, Stuart Kurten
dc.date.accessioned2015-08-03T11:17:12Zen
dc.date.available2015-08-03T11:17:12Zen
dc.date.issued2013-09-03en
dc.identifier.isbn9781627034401en
dc.identifier.issn10643745en
dc.identifier.pmid23681582en
dc.identifier.doi10.1007/978-1-62703-441-8-15en
dc.identifier.urihttp://hdl.handle.net/10754/562963en
dc.description.abstractA number of studies have shown that functionally related genes are often co-expressed and that computational based co-expression analysis can be used to accurately identify functional relationships between genes and by inference, their encoded proteins. Here we describe how a computational based co-expression analysis can be used to link the function of a specific gene of interest to a defined cellular response. Using a worked example we demonstrate how this methodology is used to link the function of the Arabidopsis Wall-Associated Kinase-Like 10 gene, which encodes a functional guanylyl cyclase, to host responses to pathogens. © Springer Science+Business Media New York 2013.en
dc.publisherHumana Pressen
dc.subjectArabidopsis thalianaen
dc.subjectcGMPen
dc.subjectCo-expressionen
dc.subjectComputational analysisen
dc.subjectFunctional annotationen
dc.subjectFunctional/biological processen
dc.subjectGuanylyl cyclaseen
dc.titleInferring biological functions of guanylyl cyclases with computational methodsen
dc.typeArticleen
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.identifier.journalMethods in Molecular Biologyen
kaust.authorMeier, Stuart Kurten
kaust.authorAlquraishi, May Majeden
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