A magnetic biosensor system for detection of E. coli

Handle URI:
http://hdl.handle.net/10754/562854
Title:
A magnetic biosensor system for detection of E. coli
Authors:
Li, Fuquan ( 0000-0002-1573-597X ) ; Kosel, Jürgen ( 0000-0002-8998-8275 )
Abstract:
This work describes a device for detecting E. coli bacteria by manipulating superparamagnetic beads to a sensing area and immobilizing them in a trapping well. The trapping well replaces the biochemical immobilization layer, which is commonly used in magnetic biosensor systems. A concept exploiting the volume difference between bare magnetic beads and magnetic bead-bioanalyte compounds is utilized to detect E. coli bacteria. Trapped beads are detected by the help of a tunnel magneto-resistive sensor. Frequency modulation is employed, in order to increase the signal-to-noise ratio, enabling the detection of individual superparamagnetic beads of 2.8 μm in diameter. Replacing the biochemical immobilization layer by the trapping well greatly simplifies the detection process. After applying the mixture of E. coli and magnetic beads to the biosensor system, bacteria detection is achieved in a single step, within a few minutes. © 2013 IEEE.
KAUST Department:
Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division; Electrical Engineering Program; Sensing, Magnetism and Microsystems Lab
Publisher:
Institute of Electrical and Electronics Engineers (IEEE)
Journal:
IEEE Transactions on Magnetics
Issue Date:
Jul-2013
DOI:
10.1109/TMAG.2013.2244580
Type:
Article
ISSN:
00189464
Appears in Collections:
Articles; Electrical Engineering Program; Sensing, Magnetism and Microsystems Lab; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorLi, Fuquanen
dc.contributor.authorKosel, Jürgenen
dc.date.accessioned2015-08-03T11:12:52Zen
dc.date.available2015-08-03T11:12:52Zen
dc.date.issued2013-07en
dc.identifier.issn00189464en
dc.identifier.doi10.1109/TMAG.2013.2244580en
dc.identifier.urihttp://hdl.handle.net/10754/562854en
dc.description.abstractThis work describes a device for detecting E. coli bacteria by manipulating superparamagnetic beads to a sensing area and immobilizing them in a trapping well. The trapping well replaces the biochemical immobilization layer, which is commonly used in magnetic biosensor systems. A concept exploiting the volume difference between bare magnetic beads and magnetic bead-bioanalyte compounds is utilized to detect E. coli bacteria. Trapped beads are detected by the help of a tunnel magneto-resistive sensor. Frequency modulation is employed, in order to increase the signal-to-noise ratio, enabling the detection of individual superparamagnetic beads of 2.8 μm in diameter. Replacing the biochemical immobilization layer by the trapping well greatly simplifies the detection process. After applying the mixture of E. coli and magnetic beads to the biosensor system, bacteria detection is achieved in a single step, within a few minutes. © 2013 IEEE.en
dc.publisherInstitute of Electrical and Electronics Engineers (IEEE)en
dc.subjectE. colien
dc.subjectfrequency modulationen
dc.subjectmagnetic biosensoren
dc.subjectsuperparmagnetic beaden
dc.titleA magnetic biosensor system for detection of E. colien
dc.typeArticleen
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Divisionen
dc.contributor.departmentElectrical Engineering Programen
dc.contributor.departmentSensing, Magnetism and Microsystems Laben
dc.identifier.journalIEEE Transactions on Magneticsen
kaust.authorKosel, Jürgenen
kaust.authorLi, Fuquanen
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