Sub-10 nm Fe3O4@Cu2-xS core-shell nanoparticles for dual-modal imaging and photothermal therapy

Handle URI:
http://hdl.handle.net/10754/562811
Title:
Sub-10 nm Fe3O4@Cu2-xS core-shell nanoparticles for dual-modal imaging and photothermal therapy
Authors:
Tian, Qiwei; Hu, Junqing; Zhu, Yihan; Zou, Rujia; Chen, Zhigang; Yang, Shiping; Li, Runwei; Su, Qianqian; Han, Yu ( 0000-0003-1462-1118 ) ; Liu, Xiaogang
Abstract:
Photothermal nanomaterials have recently attracted significant research interest due to their potential applications in biological imaging and therapeutics. However, the development of small-sized photothermal nanomaterials with high thermal stability remains a formidable challenge. Here, we report the rational design and synthesis of ultrasmall (<10 nm) Fe3O 4@Cu2-xS core-shell nanoparticles, which offer both high photothermal stability and superparamagnetic properties. Specifically, these core-shell nanoparticles have proven effective as probes for T 2-weighted magnetic resonance imaging and infrared thermal imaging because of their strong absorption at the near-infrared region centered around 960 nm. Importantly, the photothermal effect of the nanoparticles can be precisely controlled by varying the Cu content in the core-shell structure. Furthermore, we demonstrate in vitro and in vivo photothermal ablation of cancer cells using these multifunctional nanoparticles. The results should provide improved understanding of synergistic effect resulting from the integration of magnetism with photothermal phenomenon, important for developing multimode nanoparticle probes for biomedical applications. © 2013 American Chemical Society.
KAUST Department:
Advanced Membranes and Porous Materials Research Center; Biological and Environmental Sciences and Engineering (BESE) Division; Physical Sciences and Engineering (PSE) Division; Chemical Science Program; Nanostructured Functional Materials (NFM) laboratory
Publisher:
American Chemical Society (ACS)
Journal:
Journal of the American Chemical Society
Issue Date:
12-Jun-2013
DOI:
10.1021/ja4013497
PubMed ID:
23687972
Type:
Article
ISSN:
00027863
Sponsors:
This work was partially supported by the National Natural Science Foundation of China (grant nos. 21171035, 50872020, 20971086), Key Grant Project of Chinese Ministry of Education (grant no. 313015), the Science and Technology Commission of Shanghai-based "Innovation Action Plan" Project (grant no. 10JC1400100), and PhD Programs Foundation of Ministry of Education of China (grant no. 20110075110008). X.L. acknowledges the support by the National University of Singapore (R-143-000-427), the Singapore Ministry of Education (R-143-000-453), the Singapore-MIT Alliance, and the Agency for Science, Technology, and Research (R-143-000-366). Y.H. acknowledges the support by the King Abdullah University of Science and Technology for the baseline research funds.
Appears in Collections:
Articles; Advanced Membranes and Porous Materials Research Center; Physical Sciences and Engineering (PSE) Division; Chemical Science Program; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorTian, Qiweien
dc.contributor.authorHu, Junqingen
dc.contributor.authorZhu, Yihanen
dc.contributor.authorZou, Rujiaen
dc.contributor.authorChen, Zhigangen
dc.contributor.authorYang, Shipingen
dc.contributor.authorLi, Runweien
dc.contributor.authorSu, Qianqianen
dc.contributor.authorHan, Yuen
dc.contributor.authorLiu, Xiaogangen
dc.date.accessioned2015-08-03T11:11:10Zen
dc.date.available2015-08-03T11:11:10Zen
dc.date.issued2013-06-12en
dc.identifier.issn00027863en
dc.identifier.pmid23687972en
dc.identifier.doi10.1021/ja4013497en
dc.identifier.urihttp://hdl.handle.net/10754/562811en
dc.description.abstractPhotothermal nanomaterials have recently attracted significant research interest due to their potential applications in biological imaging and therapeutics. However, the development of small-sized photothermal nanomaterials with high thermal stability remains a formidable challenge. Here, we report the rational design and synthesis of ultrasmall (<10 nm) Fe3O 4@Cu2-xS core-shell nanoparticles, which offer both high photothermal stability and superparamagnetic properties. Specifically, these core-shell nanoparticles have proven effective as probes for T 2-weighted magnetic resonance imaging and infrared thermal imaging because of their strong absorption at the near-infrared region centered around 960 nm. Importantly, the photothermal effect of the nanoparticles can be precisely controlled by varying the Cu content in the core-shell structure. Furthermore, we demonstrate in vitro and in vivo photothermal ablation of cancer cells using these multifunctional nanoparticles. The results should provide improved understanding of synergistic effect resulting from the integration of magnetism with photothermal phenomenon, important for developing multimode nanoparticle probes for biomedical applications. © 2013 American Chemical Society.en
dc.description.sponsorshipThis work was partially supported by the National Natural Science Foundation of China (grant nos. 21171035, 50872020, 20971086), Key Grant Project of Chinese Ministry of Education (grant no. 313015), the Science and Technology Commission of Shanghai-based "Innovation Action Plan" Project (grant no. 10JC1400100), and PhD Programs Foundation of Ministry of Education of China (grant no. 20110075110008). X.L. acknowledges the support by the National University of Singapore (R-143-000-427), the Singapore Ministry of Education (R-143-000-453), the Singapore-MIT Alliance, and the Agency for Science, Technology, and Research (R-143-000-366). Y.H. acknowledges the support by the King Abdullah University of Science and Technology for the baseline research funds.en
dc.publisherAmerican Chemical Society (ACS)en
dc.titleSub-10 nm Fe3O4@Cu2-xS core-shell nanoparticles for dual-modal imaging and photothermal therapyen
dc.typeArticleen
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Centeren
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.contributor.departmentChemical Science Programen
dc.contributor.departmentNanostructured Functional Materials (NFM) laboratoryen
dc.identifier.journalJournal of the American Chemical Societyen
dc.contributor.institutionState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, Chinaen
dc.contributor.institutionDepartment of Chemistry, Shanghai Normal University, Shanghai 200234, Chinaen
dc.contributor.institutionKey Laboratory of Magnetic Materials and Devices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, Zhejiang, 315201, Chinaen
dc.contributor.institutionDepartment of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singaporeen
dc.contributor.institutionInstitute of Material Research and Engineering, 3 Research Link, Singapore 117602, Singaporeen
kaust.authorZhu, Yihanen
kaust.authorHan, Yuen

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