Gram-scale fractionation of nanodiamonds by density gradient ultracentrifugation

Handle URI:
http://hdl.handle.net/10754/562502
Title:
Gram-scale fractionation of nanodiamonds by density gradient ultracentrifugation
Authors:
Peng, Wei ( 0000-0002-7168-9795 ) ; Mahfouz, Remi ( 0000-0003-0981-0440 ) ; Pan, Jun; Hou, Yuanfang ( 0000-0001-6508-8777 ) ; Beaujuge, Pierre; Bakr, Osman M. ( 0000-0002-3428-1002 )
Abstract:
Size is a defining characteristic of nanoparticles; it influences their optical and electronic properties as well as their interactions with molecules and macromolecules. Producing nanoparticles with narrow size distributions remains one of the main challenges to their utilization. At this time, the number of practical approaches to optimize the size distribution of nanoparticles in many interesting materials systems, including diamond nanocrystals, remains limited. Diamond nanocrystals synthesized by detonation protocols-so-called detonation nanodiamonds (DNDs)-are promising systems for drug delivery, photonics, and composites. DNDs are composed of primary particles with diameters mainly <10 nm and their aggregates (ca. 10-500 nm). Here, we introduce a large-scale approach to rate-zonal density gradient ultracentrifugation to obtain monodispersed fractions of nanoparticles in high yields. We use this method to fractionate a highly concentrated and stable aqueous solution of DNDs and to investigate the size distribution of various fractions by dynamic light scattering, analytical ultracentrifugation, transmission electron microscopy and powder X-ray diffraction. This fractionation method enabled us to separate gram-scale amounts of DNDs into several size ranges within a relatively short period of time. In addition, the high product yields obtained for each fraction allowed us to apply the fractionation method iteratively to a particular size range of particles and to collect various fractions of highly monodispersed primary particles. Our method paves the way for in-depth studies of the physical and optical properties, growth, and aggregation mechanism of DNDs. Applications requiring DNDs with specific particle or aggregate sizes are now within reach. © 2013 The Royal Society of Chemistry.
KAUST Department:
Physical Sciences and Engineering (PSE) Division; Solar and Photovoltaic Engineering Research Center (SPERC); Materials Science and Engineering Program; Chemical Science Program; Functional Nanomaterials Lab (FuNL)
Publisher:
Royal Society of Chemistry (RSC)
Journal:
Nanoscale
Issue Date:
2013
DOI:
10.1039/c3nr00990d
PubMed ID:
23636671
Type:
Article
ISSN:
20403364
Sponsors:
The authors acknowledge the financial support of the Office of Competitive Research Funds (OCRF) at King Abdullah University of Science and Technology (KAUST) under the "Competitive Research Grant" (CRG) program no. FIC/2010/02. The authors acknowledge the use of KAUST's Analytical Chemistry Core Lab and Imaging and Characterization Core Lab. The authors thank Dr David Coombs, Dr Liang Li, and Dr Hua Tan for helpful discussions and useful scientific insights.
Appears in Collections:
Articles; Physical Sciences and Engineering (PSE) Division; Chemical Science Program; Materials Science and Engineering Program; Solar and Photovoltaic Engineering Research Center (SPERC)

Full metadata record

DC FieldValue Language
dc.contributor.authorPeng, Weien
dc.contributor.authorMahfouz, Remien
dc.contributor.authorPan, Junen
dc.contributor.authorHou, Yuanfangen
dc.contributor.authorBeaujuge, Pierreen
dc.contributor.authorBakr, Osman M.en
dc.date.accessioned2015-08-03T10:40:30Zen
dc.date.available2015-08-03T10:40:30Zen
dc.date.issued2013en
dc.identifier.issn20403364en
dc.identifier.pmid23636671en
dc.identifier.doi10.1039/c3nr00990den
dc.identifier.urihttp://hdl.handle.net/10754/562502en
dc.description.abstractSize is a defining characteristic of nanoparticles; it influences their optical and electronic properties as well as their interactions with molecules and macromolecules. Producing nanoparticles with narrow size distributions remains one of the main challenges to their utilization. At this time, the number of practical approaches to optimize the size distribution of nanoparticles in many interesting materials systems, including diamond nanocrystals, remains limited. Diamond nanocrystals synthesized by detonation protocols-so-called detonation nanodiamonds (DNDs)-are promising systems for drug delivery, photonics, and composites. DNDs are composed of primary particles with diameters mainly <10 nm and their aggregates (ca. 10-500 nm). Here, we introduce a large-scale approach to rate-zonal density gradient ultracentrifugation to obtain monodispersed fractions of nanoparticles in high yields. We use this method to fractionate a highly concentrated and stable aqueous solution of DNDs and to investigate the size distribution of various fractions by dynamic light scattering, analytical ultracentrifugation, transmission electron microscopy and powder X-ray diffraction. This fractionation method enabled us to separate gram-scale amounts of DNDs into several size ranges within a relatively short period of time. In addition, the high product yields obtained for each fraction allowed us to apply the fractionation method iteratively to a particular size range of particles and to collect various fractions of highly monodispersed primary particles. Our method paves the way for in-depth studies of the physical and optical properties, growth, and aggregation mechanism of DNDs. Applications requiring DNDs with specific particle or aggregate sizes are now within reach. © 2013 The Royal Society of Chemistry.en
dc.description.sponsorshipThe authors acknowledge the financial support of the Office of Competitive Research Funds (OCRF) at King Abdullah University of Science and Technology (KAUST) under the "Competitive Research Grant" (CRG) program no. FIC/2010/02. The authors acknowledge the use of KAUST's Analytical Chemistry Core Lab and Imaging and Characterization Core Lab. The authors thank Dr David Coombs, Dr Liang Li, and Dr Hua Tan for helpful discussions and useful scientific insights.en
dc.publisherRoyal Society of Chemistry (RSC)en
dc.titleGram-scale fractionation of nanodiamonds by density gradient ultracentrifugationen
dc.typeArticleen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.contributor.departmentSolar and Photovoltaic Engineering Research Center (SPERC)en
dc.contributor.departmentMaterials Science and Engineering Programen
dc.contributor.departmentChemical Science Programen
dc.contributor.departmentFunctional Nanomaterials Lab (FuNL)en
dc.identifier.journalNanoscaleen
kaust.authorMahfouz, Remien
kaust.authorPan, Junen
kaust.authorBeaujuge, Pierreen
kaust.authorBakr, Osman M.en
kaust.authorPeng, Weien
kaust.authorHou, Yuanfangen

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