Intracellular surface-enhanced Raman scattering (SERS) with thermally stable gold nanoflowers grown from Pt and Pd seeds

Handle URI:
http://hdl.handle.net/10754/562499
Title:
Intracellular surface-enhanced Raman scattering (SERS) with thermally stable gold nanoflowers grown from Pt and Pd seeds
Authors:
Song, Hyon Min; Deng, Lin ( 0000-0001-8954-5610 ) ; Khashab, Niveen M. ( 0000-0003-2728-0666 )
Abstract:
SERS provides great sensitivity at low concentrations of analytes. SERS combined with near infrared (NIR)-resonant gold nanomaterials are important candidates for theranostic agents due to their combined extinction properties and sensing abilities stemming from the deep penetration of laser light in the NIR region. Here, highly branched gold nanoflowers (GNFs) grown from Pd and Pt seeds are prepared and their SERS properties are studied. The growth was performed at 80°C without stirring, and this high temperature growth method is assumed to provide great shape stability of sharp tips in GNFs. We found that seed size must be large enough (>30 nm in diameter) to induce the growth of those SERS-active and thermally stable GNFs. We also found that the addition of silver nitrate (AgNO3) is important to induce sharp tip growth and shape stability. Incubation with Hela cells indicates that GNFs are taken up and reside in the cytoplasm. SERS was observed in those cells incubated with 1,10-phenanthroline (Phen)-loaded GNFs. This journal is © 2013 The Royal Society of Chemistry.
KAUST Department:
Physical Sciences and Engineering (PSE) Division; Advanced Membranes and Porous Materials Research Center; Chemical Science Program; Smart Hybrid Materials (SHMs) lab
Publisher:
Royal Society of Chemistry (RSC)
Journal:
Nanoscale
Issue Date:
2013
DOI:
10.1039/c3nr33712j
PubMed ID:
23563097
Type:
Article
ISSN:
20403364
Sponsors:
The authors gratefully acknowledge King Abdullah University of Science and Technology (KAUST) for the support of this work. The authors also acknowledge Dr Yang Yang in Imaging & Characterization Corelab in KAUST for help in Raman scattering measurements, and Jian Ren for help in confocal fluorescence microscopy measurements, and Guangchao Wang for help in TEM measurements of nanoparticle-incubated Hela cells.
Appears in Collections:
Articles; Advanced Membranes and Porous Materials Research Center; Physical Sciences and Engineering (PSE) Division; Controlled Release and Delivery Laboratory; Chemical Science Program

Full metadata record

DC FieldValue Language
dc.contributor.authorSong, Hyon Minen
dc.contributor.authorDeng, Linen
dc.contributor.authorKhashab, Niveen M.en
dc.date.accessioned2015-08-03T10:40:21Zen
dc.date.available2015-08-03T10:40:21Zen
dc.date.issued2013en
dc.identifier.issn20403364en
dc.identifier.pmid23563097en
dc.identifier.doi10.1039/c3nr33712jen
dc.identifier.urihttp://hdl.handle.net/10754/562499en
dc.description.abstractSERS provides great sensitivity at low concentrations of analytes. SERS combined with near infrared (NIR)-resonant gold nanomaterials are important candidates for theranostic agents due to their combined extinction properties and sensing abilities stemming from the deep penetration of laser light in the NIR region. Here, highly branched gold nanoflowers (GNFs) grown from Pd and Pt seeds are prepared and their SERS properties are studied. The growth was performed at 80°C without stirring, and this high temperature growth method is assumed to provide great shape stability of sharp tips in GNFs. We found that seed size must be large enough (>30 nm in diameter) to induce the growth of those SERS-active and thermally stable GNFs. We also found that the addition of silver nitrate (AgNO3) is important to induce sharp tip growth and shape stability. Incubation with Hela cells indicates that GNFs are taken up and reside in the cytoplasm. SERS was observed in those cells incubated with 1,10-phenanthroline (Phen)-loaded GNFs. This journal is © 2013 The Royal Society of Chemistry.en
dc.description.sponsorshipThe authors gratefully acknowledge King Abdullah University of Science and Technology (KAUST) for the support of this work. The authors also acknowledge Dr Yang Yang in Imaging & Characterization Corelab in KAUST for help in Raman scattering measurements, and Jian Ren for help in confocal fluorescence microscopy measurements, and Guangchao Wang for help in TEM measurements of nanoparticle-incubated Hela cells.en
dc.publisherRoyal Society of Chemistry (RSC)en
dc.titleIntracellular surface-enhanced Raman scattering (SERS) with thermally stable gold nanoflowers grown from Pt and Pd seedsen
dc.typeArticleen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Centeren
dc.contributor.departmentChemical Science Programen
dc.contributor.departmentSmart Hybrid Materials (SHMs) laben
dc.identifier.journalNanoscaleen
kaust.authorDeng, Linen
kaust.authorKhashab, Niveen M.en
kaust.authorSong, Hyon Minen
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