A magnetic method to concentrate and trap biological targets

Handle URI:
http://hdl.handle.net/10754/562388
Title:
A magnetic method to concentrate and trap biological targets
Authors:
Li, Fuquan ( 0000-0002-1573-597X ) ; Kosel, Jürgen ( 0000-0002-8998-8275 )
Abstract:
Magnetoresistive sensors in combination with magnetic particles have been used in biological applications due to, e.g., their small size and high sensitivity. A growing interest is to integrate magnetoresistive sensors with microchannels and electronics to fabricate devices that can perform complex analyses. A major task in such systems is to immobilize magnetic particles on top of the sensor surface, which is required to detect the particles' stray field. In the presented work, a bead concentrator, consisting of gold microstructures, at the bottom of a microchannel, is used to attract and move magnetic particles into a trap. The trap is made of a chamber with a gold microstructure underneath and is used to attract and immobilize a defined number of magnetic beads. In order to detect targets, two kinds of solutions were prepared; one containing only superparamagnetic particles, the other one containing beads with the protein Bovine serum albumin as the target and fluorescent markers. Due to the size difference between bare beads and beads with target, less magnetic beads were immobilized inside the volume chamber in case of magnetic beads with target as compared to bare magnetic beads. © 1965-2012 IEEE.
KAUST Department:
Physical Sciences and Engineering (PSE) Division; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division; Electrical Engineering Program; Sensing, Magnetism and Microsystems Lab
Publisher:
Institute of Electrical and Electronics Engineers (IEEE)
Journal:
IEEE Transactions on Magnetics
Issue Date:
Nov-2012
DOI:
10.1109/TMAG.2012.2202644
Type:
Article
ISSN:
00189464
Appears in Collections:
Articles; Physical Sciences and Engineering (PSE) Division; Electrical Engineering Program; Sensing, Magnetism and Microsystems Lab; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorLi, Fuquanen
dc.contributor.authorKosel, Jürgenen
dc.date.accessioned2015-08-03T10:03:27Zen
dc.date.available2015-08-03T10:03:27Zen
dc.date.issued2012-11en
dc.identifier.issn00189464en
dc.identifier.doi10.1109/TMAG.2012.2202644en
dc.identifier.urihttp://hdl.handle.net/10754/562388en
dc.description.abstractMagnetoresistive sensors in combination with magnetic particles have been used in biological applications due to, e.g., their small size and high sensitivity. A growing interest is to integrate magnetoresistive sensors with microchannels and electronics to fabricate devices that can perform complex analyses. A major task in such systems is to immobilize magnetic particles on top of the sensor surface, which is required to detect the particles' stray field. In the presented work, a bead concentrator, consisting of gold microstructures, at the bottom of a microchannel, is used to attract and move magnetic particles into a trap. The trap is made of a chamber with a gold microstructure underneath and is used to attract and immobilize a defined number of magnetic beads. In order to detect targets, two kinds of solutions were prepared; one containing only superparamagnetic particles, the other one containing beads with the protein Bovine serum albumin as the target and fluorescent markers. Due to the size difference between bare beads and beads with target, less magnetic beads were immobilized inside the volume chamber in case of magnetic beads with target as compared to bare magnetic beads. © 1965-2012 IEEE.en
dc.publisherInstitute of Electrical and Electronics Engineers (IEEE)en
dc.subjectBiological detectionen
dc.subjectimmobilizationen
dc.subjectmagnetic beadsen
dc.subjectmagnetic biosensoren
dc.titleA magnetic method to concentrate and trap biological targetsen
dc.typeArticleen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Divisionen
dc.contributor.departmentElectrical Engineering Programen
dc.contributor.departmentSensing, Magnetism and Microsystems Laben
dc.identifier.journalIEEE Transactions on Magneticsen
kaust.authorKosel, Jürgenen
kaust.authorLi, Fuquanen
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