Overview of errors in the reference sequence and annotation of Mycobacterium tuberculosis H37Rv, and variation amongst its isolates

Handle URI:
http://hdl.handle.net/10754/562208
Title:
Overview of errors in the reference sequence and annotation of Mycobacterium tuberculosis H37Rv, and variation amongst its isolates
Authors:
Köser, Claudio U.; Niemann, Stefan; Summers, David K.; Archer, John A.C. ( 0000-0002-3302-3933 )
Abstract:
Since its publication in 1998, the genome sequence of the Mycobacterium tuberculosis H37Rv laboratory strain has acted as the cornerstone for the study of tuberculosis. In this review we address some of the practical aspects that have come to light relating to the use of H37Rv throughout the past decade which are of relevance for the ongoing genomic and laboratory studies of this pathogen. These include errors in the genome reference sequence and its annotation, as well as the recently detected variation amongst isolates of H37Rv from different laboratories. © 2011 Elsevier B.V..
KAUST Department:
Computational Bioscience Research Center (CBRC)
Publisher:
Elsevier
Journal:
Infection, Genetics and Evolution
Issue Date:
Jun-2012
DOI:
10.1016/j.meegid.2011.06.011
PubMed ID:
21723422
Type:
Article
ISSN:
15671348
Sponsors:
Claudio U. Koser is a Gates Cambridge Scholar and received additional funding from the Cambridge Philosophical Society, the Cambridge European Trust and Clare Hall, Cambridge. We thank D. Collins, J. Parkhill, F. Spies, and S. Okamo for sharing some of their data. We are also grateful to S. Gagneux for proofreading this paper.
Appears in Collections:
Articles; Computational Bioscience Research Center (CBRC)

Full metadata record

DC FieldValue Language
dc.contributor.authorKöser, Claudio U.en
dc.contributor.authorNiemann, Stefanen
dc.contributor.authorSummers, David K.en
dc.contributor.authorArcher, John A.C.en
dc.date.accessioned2015-08-03T09:47:17Zen
dc.date.available2015-08-03T09:47:17Zen
dc.date.issued2012-06en
dc.identifier.issn15671348en
dc.identifier.pmid21723422en
dc.identifier.doi10.1016/j.meegid.2011.06.011en
dc.identifier.urihttp://hdl.handle.net/10754/562208en
dc.description.abstractSince its publication in 1998, the genome sequence of the Mycobacterium tuberculosis H37Rv laboratory strain has acted as the cornerstone for the study of tuberculosis. In this review we address some of the practical aspects that have come to light relating to the use of H37Rv throughout the past decade which are of relevance for the ongoing genomic and laboratory studies of this pathogen. These include errors in the genome reference sequence and its annotation, as well as the recently detected variation amongst isolates of H37Rv from different laboratories. © 2011 Elsevier B.V..en
dc.description.sponsorshipClaudio U. Koser is a Gates Cambridge Scholar and received additional funding from the Cambridge Philosophical Society, the Cambridge European Trust and Clare Hall, Cambridge. We thank D. Collins, J. Parkhill, F. Spies, and S. Okamo for sharing some of their data. We are also grateful to S. Gagneux for proofreading this paper.en
dc.publisherElsevieren
dc.subjectAnnotation errorsen
dc.subjectIsolate variationen
dc.subjectMycobacterium tuberculosis H37Rven
dc.subjectSequencing errorsen
dc.titleOverview of errors in the reference sequence and annotation of Mycobacterium tuberculosis H37Rv, and variation amongst its isolatesen
dc.typeArticleen
dc.contributor.departmentComputational Bioscience Research Center (CBRC)en
dc.identifier.journalInfection, Genetics and Evolutionen
dc.contributor.institutionDepartment of Genetics, University of Cambridge, Cambridge, United Kingdomen
dc.contributor.institutionMolecular Mycobacteriology, Research Center Borstel, Borstel, Germanyen
kaust.authorArcher, John A.C.en

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