A planar conducting micro-loop structure for transportation of magnetic beads: An approach towards rapid sensing and quantification of biological entities

Handle URI:
http://hdl.handle.net/10754/562122
Title:
A planar conducting micro-loop structure for transportation of magnetic beads: An approach towards rapid sensing and quantification of biological entities
Authors:
Gooneratne, Chinthaka Pasan; Giouroudi, Ioanna; Kosel, Jürgen ( 0000-0002-8998-8275 )
Abstract:
Magnetic beads are utilized effectively in a wide variety of medical applications due to their small size, biocompatibility and large surface to volume ratio. Microfluidic lab-on-a-chip (LOC) devices, which utilize magnetic beads, are promising tools for accurate and rapid cell sorting and counting. Effective manipulation of beads is a critical factor for the performance of LOC devices. In this paper we propose a planar conducting micro-loop structure to trap, manipulate and transport magnetic beads. Current through the micro-loops produces magnetic field gradients that are proportional to the force required to manipulate the beads. Numerical analyses were performed to study the magnetic forces and their spatial distributions. Experimental results showed that magnetic beads could not only be transported towards a target region, e.g., for sensing purposes, but also the trapping rate could be increased by switching current between the different loops in the micro-loop structure. This method could lead to rapid and accurate quantification of biological entities tagged with magnetic beads. Copyright © 2012 American Scientific Publishers. All rights reserved.
KAUST Department:
Physical Sciences and Engineering (PSE) Division; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division; Electrical Engineering Program; Sensing, Magnetism and Microsystems Lab
Publisher:
American Scientific Publishers
Journal:
Sensor Letters
Issue Date:
1-Mar-2012
DOI:
10.1166/sl.2012.2583
Type:
Article
ISSN:
1546198X
Appears in Collections:
Articles; Physical Sciences and Engineering (PSE) Division; Electrical Engineering Program; Sensing, Magnetism and Microsystems Lab; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorGooneratne, Chinthaka Pasanen
dc.contributor.authorGiouroudi, Ioannaen
dc.contributor.authorKosel, Jürgenen
dc.date.accessioned2015-08-03T09:45:19Zen
dc.date.available2015-08-03T09:45:19Zen
dc.date.issued2012-03-01en
dc.identifier.issn1546198Xen
dc.identifier.doi10.1166/sl.2012.2583en
dc.identifier.urihttp://hdl.handle.net/10754/562122en
dc.description.abstractMagnetic beads are utilized effectively in a wide variety of medical applications due to their small size, biocompatibility and large surface to volume ratio. Microfluidic lab-on-a-chip (LOC) devices, which utilize magnetic beads, are promising tools for accurate and rapid cell sorting and counting. Effective manipulation of beads is a critical factor for the performance of LOC devices. In this paper we propose a planar conducting micro-loop structure to trap, manipulate and transport magnetic beads. Current through the micro-loops produces magnetic field gradients that are proportional to the force required to manipulate the beads. Numerical analyses were performed to study the magnetic forces and their spatial distributions. Experimental results showed that magnetic beads could not only be transported towards a target region, e.g., for sensing purposes, but also the trapping rate could be increased by switching current between the different loops in the micro-loop structure. This method could lead to rapid and accurate quantification of biological entities tagged with magnetic beads. Copyright © 2012 American Scientific Publishers. All rights reserved.en
dc.publisherAmerican Scientific Publishersen
dc.subjectDiagnostic Systemsen
dc.subjectLOCen
dc.subjectMagnetic Beaden
dc.subjectMicro-Loopen
dc.subjectMicrodevicesen
dc.titleA planar conducting micro-loop structure for transportation of magnetic beads: An approach towards rapid sensing and quantification of biological entitiesen
dc.typeArticleen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Divisionen
dc.contributor.departmentElectrical Engineering Programen
dc.contributor.departmentSensing, Magnetism and Microsystems Laben
dc.identifier.journalSensor Lettersen
dc.contributor.institutionInstitute of Sensor and Actuator Systems, Vienna University of Technology, Vienna A-1040, Austriaen
kaust.authorGooneratne, Chinthaka Pasanen
kaust.authorKosel, Jürgenen
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