Enzymatically triggered multifunctional delivery system based on hyaluronic acid micelles

Handle URI:
http://hdl.handle.net/10754/562029
Title:
Enzymatically triggered multifunctional delivery system based on hyaluronic acid micelles
Authors:
Deng, Lin ( 0000-0001-8954-5610 ) ; Wang, Guangchao; Ren, Jian; Zhang, Bei; Yan, Jingjing; Li, Wengang ( 0000-0002-1838-8360 ) ; Khashab, Niveen M. ( 0000-0003-2728-0666 )
Abstract:
Tumor targetability and stimuli responsivity of drug delivery systems (DDS) are key factors in cancer therapy. Implementation of multifunctional DDS can afford targetability and responsivity at the same time. Herein, cholesterol molecules (Ch) were coupled to hyaluronic acid (HA) backbones to afford amphiphilic conjugates that can self-assemble into stable micelles. Doxorubicin (DOX), an anticancer drug, and superparamagnetic iron oxide (SPIO) nanoparticles (NPs), magnetic resonance imaging (MRI) contrast agents, were encapsulated by Ch-HA micelles and were selectively released in the presence of hyaluronidase (Hyals) enzyme. Cytotoxicity and cell uptake studies were done using three cancer cell lines (HeLa, HepG2 and MCF7) and one normal cell line (WI38). Higher Ch-HA micelles uptake was seen in cancer cells versus normal cells. Consequently, DOX release was elevated in cancer cells causing higher cytotoxicity and enhanced cell death. © 2012 The Royal Society of Chemistry.
KAUST Department:
Advanced Membranes and Porous Materials Research Center; Biological and Environmental Sciences and Engineering (BESE) Division; Advanced Nanofabrication, Imaging and Characterization Core Lab; Physical Sciences and Engineering (PSE) Division; Chemical Science Program; Core Labs; Smart Hybrid Materials (SHMs) lab
Publisher:
Royal Society of Chemistry
Journal:
RSC Advances
Issue Date:
2012
DOI:
10.1039/c2ra21888g
Type:
Article
ISSN:
20462069
Appears in Collections:
Articles; Advanced Membranes and Porous Materials Research Center; Advanced Nanofabrication, Imaging and Characterization Core Lab; Physical Sciences and Engineering (PSE) Division; Controlled Release and Delivery Laboratory; Chemical Science Program; Biological and Environmental Sciences and Engineering (BESE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorDeng, Linen
dc.contributor.authorWang, Guangchaoen
dc.contributor.authorRen, Jianen
dc.contributor.authorZhang, Beien
dc.contributor.authorYan, Jingjingen
dc.contributor.authorLi, Wengangen
dc.contributor.authorKhashab, Niveen M.en
dc.date.accessioned2015-08-03T09:43:10Zen
dc.date.available2015-08-03T09:43:10Zen
dc.date.issued2012en
dc.identifier.issn20462069en
dc.identifier.doi10.1039/c2ra21888gen
dc.identifier.urihttp://hdl.handle.net/10754/562029en
dc.description.abstractTumor targetability and stimuli responsivity of drug delivery systems (DDS) are key factors in cancer therapy. Implementation of multifunctional DDS can afford targetability and responsivity at the same time. Herein, cholesterol molecules (Ch) were coupled to hyaluronic acid (HA) backbones to afford amphiphilic conjugates that can self-assemble into stable micelles. Doxorubicin (DOX), an anticancer drug, and superparamagnetic iron oxide (SPIO) nanoparticles (NPs), magnetic resonance imaging (MRI) contrast agents, were encapsulated by Ch-HA micelles and were selectively released in the presence of hyaluronidase (Hyals) enzyme. Cytotoxicity and cell uptake studies were done using three cancer cell lines (HeLa, HepG2 and MCF7) and one normal cell line (WI38). Higher Ch-HA micelles uptake was seen in cancer cells versus normal cells. Consequently, DOX release was elevated in cancer cells causing higher cytotoxicity and enhanced cell death. © 2012 The Royal Society of Chemistry.en
dc.publisherRoyal Society of Chemistryen
dc.titleEnzymatically triggered multifunctional delivery system based on hyaluronic acid micellesen
dc.typeArticleen
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Centeren
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.contributor.departmentAdvanced Nanofabrication, Imaging and Characterization Core Laben
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.contributor.departmentChemical Science Programen
dc.contributor.departmentCore Labsen
dc.contributor.departmentSmart Hybrid Materials (SHMs) laben
dc.identifier.journalRSC Advancesen
kaust.authorDeng, Linen
kaust.authorWang, Guangchaoen
kaust.authorRen, Jianen
kaust.authorZhang, Beien
kaust.authorLi, Wengangen
kaust.authorKhashab, Niveen M.en
kaust.authorYan, Jingjingen
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