Zippered release from polymer-gated carbon nanotubes

Handle URI:
http://hdl.handle.net/10754/561987
Title:
Zippered release from polymer-gated carbon nanotubes
Authors:
Mashat, Afnan; Deng, Lin ( 0000-0001-8954-5610 ) ; Altawashi, Azza; Sougrat, Rachid; Wang, Guangchao; Khashab, Niveen M. ( 0000-0003-2728-0666 )
Abstract:
A thermosensitive drug delivery system based on polymer-gated carbon nanotubes (CNTs) that are loaded with the anticancer drug doxorubicin (DOX) is herein reported. The development of carbon nanotubes for various biomedical applications is the research focus of many research groups and holds great promise. The major drawback of these materials is the toxicity that is associated with conjugated carbon systems. Functionalization of CNTs with polymers has proved very successful in lowering the toxicity and improving the pharmacokinetic profile. In this work, CNTs are coated with polyethylenimine (PEI) and polyvinyl alcohol (PVA) via the "zipper effect" that provides both support and control over drug release. PEI/PVA provides excellent support to increase DOX loading on the nanocarrier. The system is controlled by changes in temperature due to the complexation (low temperature) and decomplexation (high temperature) of PEI and PVA via hydrogen bonding. The release of DOX was tested in three cell lines (Lung fibroblast (LF), Breast Adenocarcinoma (BA), and HeLa). It was further tested in primary cell lines (Human Dermal Fibroblast adult (HDFa) and Human Dermal Fibroblast neonatal (HDFn)). When the bonds between PEI and PVA are decomplexed at high temperature (≥40 °C), drug release was observed as verified by fluorescence microscopy. There was no drug release at room temperature (25 °C) and a slow release at normal body temperature (37 °C). This system represents a promising method for incorporating stimuli triggered polymer-gated CNTs in future controlled release applications. © 2012 The Royal Society of Chemistry.
KAUST Department:
Advanced Membranes and Porous Materials Research Center; Smart Hybrid Materials (SHMs) lab; Biological and Environmental Sciences and Engineering (BESE) Division; Advanced Nanofabrication, Imaging and Characterization Core Lab; Physical Sciences and Engineering (PSE) Division; Chemical Science Program; Environmental Science and Engineering Program; Core Labs; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Publisher:
Royal Society of Chemistry
Journal:
Journal of Materials Chemistry
Issue Date:
2012
DOI:
10.1039/c2jm30454f
Type:
Article
ISSN:
09599428
Sponsors:
The research presented is fully sponsored by King Abdullah University of Science and Technology (KAUST). We thank Dr. Mustafa Ali for all the support and helpful discussions.
Appears in Collections:
Articles; Advanced Membranes and Porous Materials Research Center; Environmental Science and Engineering Program; Advanced Nanofabrication, Imaging and Characterization Core Lab; Physical Sciences and Engineering (PSE) Division; Controlled Release and Delivery Laboratory; Chemical Science Program; Biological and Environmental Sciences and Engineering (BESE) Division; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorMashat, Afnanen
dc.contributor.authorDeng, Linen
dc.contributor.authorAltawashi, Azzaen
dc.contributor.authorSougrat, Rachiden
dc.contributor.authorWang, Guangchaoen
dc.contributor.authorKhashab, Niveen M.en
dc.date.accessioned2015-08-03T09:35:40Zen
dc.date.available2015-08-03T09:35:40Zen
dc.date.issued2012en
dc.identifier.issn09599428en
dc.identifier.doi10.1039/c2jm30454fen
dc.identifier.urihttp://hdl.handle.net/10754/561987en
dc.description.abstractA thermosensitive drug delivery system based on polymer-gated carbon nanotubes (CNTs) that are loaded with the anticancer drug doxorubicin (DOX) is herein reported. The development of carbon nanotubes for various biomedical applications is the research focus of many research groups and holds great promise. The major drawback of these materials is the toxicity that is associated with conjugated carbon systems. Functionalization of CNTs with polymers has proved very successful in lowering the toxicity and improving the pharmacokinetic profile. In this work, CNTs are coated with polyethylenimine (PEI) and polyvinyl alcohol (PVA) via the "zipper effect" that provides both support and control over drug release. PEI/PVA provides excellent support to increase DOX loading on the nanocarrier. The system is controlled by changes in temperature due to the complexation (low temperature) and decomplexation (high temperature) of PEI and PVA via hydrogen bonding. The release of DOX was tested in three cell lines (Lung fibroblast (LF), Breast Adenocarcinoma (BA), and HeLa). It was further tested in primary cell lines (Human Dermal Fibroblast adult (HDFa) and Human Dermal Fibroblast neonatal (HDFn)). When the bonds between PEI and PVA are decomplexed at high temperature (≥40 °C), drug release was observed as verified by fluorescence microscopy. There was no drug release at room temperature (25 °C) and a slow release at normal body temperature (37 °C). This system represents a promising method for incorporating stimuli triggered polymer-gated CNTs in future controlled release applications. © 2012 The Royal Society of Chemistry.en
dc.description.sponsorshipThe research presented is fully sponsored by King Abdullah University of Science and Technology (KAUST). We thank Dr. Mustafa Ali for all the support and helpful discussions.en
dc.publisherRoyal Society of Chemistryen
dc.titleZippered release from polymer-gated carbon nanotubesen
dc.typeArticleen
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Centeren
dc.contributor.departmentSmart Hybrid Materials (SHMs) laben
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Divisionen
dc.contributor.departmentAdvanced Nanofabrication, Imaging and Characterization Core Laben
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.contributor.departmentChemical Science Programen
dc.contributor.departmentEnvironmental Science and Engineering Programen
dc.contributor.departmentCore Labsen
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Divisionen
dc.identifier.journalJournal of Materials Chemistryen
kaust.authorMashat, Afnanen
kaust.authorDeng, Linen
kaust.authorAltawashi, Azzaen
kaust.authorSougrat, Rachiden
kaust.authorWang, Guangchaoen
kaust.authorKhashab, Niveen M.en
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