Evolution of acoustically vaporized microdroplets in gas embolotherapy

Handle URI:
http://hdl.handle.net/10754/561977
Title:
Evolution of acoustically vaporized microdroplets in gas embolotherapy
Authors:
Qamar, Adnan; Wong, ZhengZheng; Fowlkes, Brian Brian; Bull, Joseph L.
Abstract:
Acoustic vaporization dynamics of a superheated dodecafluoropentane (DDFP) microdroplet inside a microtube and the resulting bubble evolution is investigated in the present work. This work is motivated by a developmental gas embolotherapy technique that is intended to treat cancers by infarcting tumors using gas bubbles. A combined theoretical and computational approach is utilized and compared with the experiments to understand the evolution process and to estimate the resulting stress distribution associated with vaporization event. The transient bubble growth is first studied by ultra-high speed imaging and then theoretical and computational modeling is used to predict the entire bubble evolution process. The evolution process consists of three regimes: an initial linear rapid spherical growth followed by a linear compressed oval shaped growth and finally a slow asymptotic nonlinear spherical bubble growth. Although the droplets are small compared to the tube diameter, the bubble evolution is influenced by the tube wall. The final bubble radius is found to scale linearly with the initial droplet radius and is approximately five times the initial droplet radius. A short pressure pulse with amplitude almost twice as that of ambient conditions is observed. The width of this pressure pulse increases with increasing droplet size whereas the amplitude is weakly dependent. Although the rise in shear stress along the tube wall is found to be under peak physiological limits, the shear stress amplitude is found to be more prominently influenced by the initial droplet size. The role of viscous dissipation along the tube wall and ambient bulk fluid pressure is found to be significant in bubble evolution dynamics. © 2012 American Society of Mechanical Engineers.
KAUST Department:
Physical Sciences and Engineering (PSE) Division
Publisher:
American Society of Mechanical Engineers
Journal:
Journal of Biomechanical Engineering
Issue Date:
2012
DOI:
10.1115/1.4005980
PubMed ID:
22482690
PubMed Central ID:
PMC3705833
Type:
Article
ISSN:
01480731
Sponsors:
This work was funded by NIH Grant No. R01EB006476.
Additional Links:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705833
Appears in Collections:
Articles; Physical Sciences and Engineering (PSE) Division

Full metadata record

DC FieldValue Language
dc.contributor.authorQamar, Adnanen
dc.contributor.authorWong, ZhengZhengen
dc.contributor.authorFowlkes, Brian Brianen
dc.contributor.authorBull, Joseph L.en
dc.date.accessioned2015-08-03T09:35:27Zen
dc.date.available2015-08-03T09:35:27Zen
dc.date.issued2012en
dc.identifier.issn01480731en
dc.identifier.pmid22482690en
dc.identifier.doi10.1115/1.4005980en
dc.identifier.urihttp://hdl.handle.net/10754/561977en
dc.description.abstractAcoustic vaporization dynamics of a superheated dodecafluoropentane (DDFP) microdroplet inside a microtube and the resulting bubble evolution is investigated in the present work. This work is motivated by a developmental gas embolotherapy technique that is intended to treat cancers by infarcting tumors using gas bubbles. A combined theoretical and computational approach is utilized and compared with the experiments to understand the evolution process and to estimate the resulting stress distribution associated with vaporization event. The transient bubble growth is first studied by ultra-high speed imaging and then theoretical and computational modeling is used to predict the entire bubble evolution process. The evolution process consists of three regimes: an initial linear rapid spherical growth followed by a linear compressed oval shaped growth and finally a slow asymptotic nonlinear spherical bubble growth. Although the droplets are small compared to the tube diameter, the bubble evolution is influenced by the tube wall. The final bubble radius is found to scale linearly with the initial droplet radius and is approximately five times the initial droplet radius. A short pressure pulse with amplitude almost twice as that of ambient conditions is observed. The width of this pressure pulse increases with increasing droplet size whereas the amplitude is weakly dependent. Although the rise in shear stress along the tube wall is found to be under peak physiological limits, the shear stress amplitude is found to be more prominently influenced by the initial droplet size. The role of viscous dissipation along the tube wall and ambient bulk fluid pressure is found to be significant in bubble evolution dynamics. © 2012 American Society of Mechanical Engineers.en
dc.description.sponsorshipThis work was funded by NIH Grant No. R01EB006476.en
dc.publisherAmerican Society of Mechanical Engineersen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705833en
dc.titleEvolution of acoustically vaporized microdroplets in gas embolotherapyen
dc.typeArticleen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.identifier.journalJournal of Biomechanical Engineeringen
dc.identifier.pmcidPMC3705833en
dc.contributor.institutionDepartment of Biomedical Engineering, University of Michigan, Ann Arbor 48109, United Statesen
dc.contributor.institutionDepartment of Radiology, University of Michigan, Ann Arbor 48109, MI, United Statesen
kaust.authorQamar, Adnanen

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