Porous polymer monoliths functionalized through copolymerization of a C60 fullerene-containing methacrylate monomer for highly efficient separations of small molecules

Handle URI:
http://hdl.handle.net/10754/561958
Title:
Porous polymer monoliths functionalized through copolymerization of a C60 fullerene-containing methacrylate monomer for highly efficient separations of small molecules
Authors:
Chambers, Stuart D.; Holcombe, Thomas W.; Švec, František; Frechet, Jean ( 0000-0001-6419-0163 )
Abstract:
Monolithic poly(glycidyl methacrylate-co-ethylene dimethacrylate) and poly(butyl methacrylate-co-ethylene dimethacrylate) capillary columns, which incorporate the new monomer [6,6]-phenyl-C 61-butyric acid 2-hydroxyethyl methacrylate ester, have been prepared and their chromatographic performance have been tested for the separation of small molecules in the reversed phase. While addition of the C60-fullerene monomer to the glycidyl methacrylate-based monolith enhanced column efficiency 18-fold, to 85 000 plates/m at a linear velocity of 0.46 mm/s and a retention factor of 2.6, when compared to the parent monolith, the use of butyl methacrylate together with the carbon nanostructured monomer afforded monolithic columns with an efficiency for benzene exceeding 110 000 plates/m at a linear velocity of 0.32 mm/s and a retention factor of 4.2. This high efficiency is unprecedented for separations using porous polymer monoliths operating in an isocratic mode. Optimization of the chromatographic parameters affords near baseline separation of 6 alkylbenzenes in 3 min with an efficiency of 64 000 plates/m. The presence of 1 wt % or more of water in the polymerization mixture has a large effect on both the formation and reproducibility of the monoliths. Other factors such as nitrogen exposure, polymerization conditions, capillary filling method, and sonication parameters were all found to be important in producing highly efficient and reproducible monoliths. © 2011 American Chemical Society.
KAUST Department:
Chemical Science Program; Physical Sciences and Engineering (PSE) Division
Publisher:
American Chemical Society (ACS)
Journal:
Analytical Chemistry
Issue Date:
15-Dec-2011
DOI:
10.1021/ac202183g
PubMed ID:
22044302
PubMed Central ID:
PMC3418882
Type:
Article
ISSN:
00032700
Sponsors:
All experimental and characterization work performed at the Molecular Foundry, Lawrence Berkeley National Laboratory, and F.S. were supported by the Office of Science, Office of Basic Energy Sciences, Scientific User Facilities Division of the U.S. Department of Energy, under Contract No. DE-AC02-05CH11231. Financial support of S.D.C. and J.M.J.F by a grant from the National Institute of Health (GM48364) is gratefully acknowledged.
Additional Links:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418882
Appears in Collections:
Articles; Physical Sciences and Engineering (PSE) Division; Chemical Science Program

Full metadata record

DC FieldValue Language
dc.contributor.authorChambers, Stuart D.en
dc.contributor.authorHolcombe, Thomas W.en
dc.contributor.authorŠvec, Františeken
dc.contributor.authorFrechet, Jeanen
dc.date.accessioned2015-08-03T09:35:02Zen
dc.date.available2015-08-03T09:35:02Zen
dc.date.issued2011-12-15en
dc.identifier.issn00032700en
dc.identifier.pmid22044302en
dc.identifier.doi10.1021/ac202183gen
dc.identifier.urihttp://hdl.handle.net/10754/561958en
dc.description.abstractMonolithic poly(glycidyl methacrylate-co-ethylene dimethacrylate) and poly(butyl methacrylate-co-ethylene dimethacrylate) capillary columns, which incorporate the new monomer [6,6]-phenyl-C 61-butyric acid 2-hydroxyethyl methacrylate ester, have been prepared and their chromatographic performance have been tested for the separation of small molecules in the reversed phase. While addition of the C60-fullerene monomer to the glycidyl methacrylate-based monolith enhanced column efficiency 18-fold, to 85 000 plates/m at a linear velocity of 0.46 mm/s and a retention factor of 2.6, when compared to the parent monolith, the use of butyl methacrylate together with the carbon nanostructured monomer afforded monolithic columns with an efficiency for benzene exceeding 110 000 plates/m at a linear velocity of 0.32 mm/s and a retention factor of 4.2. This high efficiency is unprecedented for separations using porous polymer monoliths operating in an isocratic mode. Optimization of the chromatographic parameters affords near baseline separation of 6 alkylbenzenes in 3 min with an efficiency of 64 000 plates/m. The presence of 1 wt % or more of water in the polymerization mixture has a large effect on both the formation and reproducibility of the monoliths. Other factors such as nitrogen exposure, polymerization conditions, capillary filling method, and sonication parameters were all found to be important in producing highly efficient and reproducible monoliths. © 2011 American Chemical Society.en
dc.description.sponsorshipAll experimental and characterization work performed at the Molecular Foundry, Lawrence Berkeley National Laboratory, and F.S. were supported by the Office of Science, Office of Basic Energy Sciences, Scientific User Facilities Division of the U.S. Department of Energy, under Contract No. DE-AC02-05CH11231. Financial support of S.D.C. and J.M.J.F by a grant from the National Institute of Health (GM48364) is gratefully acknowledged.en
dc.publisherAmerican Chemical Society (ACS)en
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418882en
dc.titlePorous polymer monoliths functionalized through copolymerization of a C60 fullerene-containing methacrylate monomer for highly efficient separations of small moleculesen
dc.typeArticleen
dc.contributor.departmentChemical Science Programen
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Divisionen
dc.identifier.journalAnalytical Chemistryen
dc.identifier.pmcidPMC3418882en
dc.contributor.institutionDepartment of Chemistry, University of California, Berkeley, CA 94720, United Statesen
dc.contributor.institutionMolecular Foundry, E. O. Lawrence Berkeley National Laboratory, Berkeley, CA 94720, United Statesen
kaust.authorFrechet, Jeanen
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